- Home
- Publications
- Publication Search
- Publication Details
Title
Fusion transcripts: Unexploited vulnerabilities in cancer?
Authors
Keywords
-
Journal
Wiley Interdisciplinary Reviews-RNA
Volume -, Issue -, Pages e1562
Publisher
Wiley
Online
2019-08-13
DOI
10.1002/wrna.1562
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview
- (2019) Michele Baccarani et al. LEUKEMIA
- Diagnosis of fusion genes using targeted RNA sequencing
- (2019) Erin E. Heyer et al. Nature Communications
- The current state and future directions of RNAi-based therapeutics
- (2019) Ryan L. Setten et al. NATURE REVIEWS DRUG DISCOVERY
- Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of Alectinib in Untreated ALK-positive Advanced Non-small-cell Lung Cancer in the Global Phase III ALEX Study
- (2019) D. Ross Camidge et al. Journal of Thoracic Oncology
- RNA-Targeted Therapeutics
- (2018) Stanley T. Crooke et al. Cell Metabolism
- Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer
- (2018) Jessica J. Lin et al. JOURNAL OF CLINICAL ONCOLOGY
- Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
- (2018) Federico Rossari et al. Journal of Hematology & Oncology
- Sequence, Structure, and Context Preferences of Human RNA Binding Proteins
- (2018) Daniel Dominguez et al. MOLECULAR CELL
- Tapping the RNA world for therapeutics
- (2018) Judy Lieberman NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanistic studies of a small-molecule modulator of SMN2 splicing
- (2018) Jingxin Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tapping the RNA world for therapeutics
- (2018) Judy Lieberman NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
- (2018) Qingsong Gao et al. Cell Reports
- Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)
- (2018) Hasane Ratni et al. JOURNAL OF MEDICINAL CHEMISTRY
- A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier
- (2018) Stefan Sturm et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment
- (2018) Christopher A. French PATHOLOGY INTERNATIONAL
- The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties
- (2018) Samantha L. Jumbe et al. Translational Oncology
- Mechanistic insights into precursor messenger RNA splicing by the spliceosome
- (2017) Yigong Shi NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor–Positive Breast Cancer
- (2017) Karina J. Matissek et al. Cancer Discovery
- BCR-ABL1 tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia
- (2017) Sandra Cuellar et al. JOURNAL OF ONCOLOGY PHARMACY PRACTICE
- The development of agents targeting the BCR-ABL tyrosine kinase as Philadelphia chromosome-positive acute lymphoblastic leukemia treatment
- (2016) Xavier Thomas et al. Expert Opinion on Drug Discovery
- The hnRNP family: insights into their role in health and disease
- (2016) Thomas Geuens et al. HUMAN GENETICS
- Differential Crizotinib Response Duration Among ALK Fusion Variants in ALK-Positive Non–Small-Cell Lung Cancer
- (2016) Tatsuya Yoshida et al. JOURNAL OF CLINICAL ONCOLOGY
- Resistance to imatinib in patients with chronic myelogenous leukemia and the splice variant BCR-ABL1 35INS
- (2016) Ellin Berman et al. LEUKEMIA RESEARCH
- ChiTaRS-3.1—the enhanced chimeric transcripts and RNA-seq database matched with protein–protein interactions
- (2016) Alessandro Gorohovski et al. NUCLEIC ACIDS RESEARCH
- Splice-switching antisense oligonucleotides as therapeutic drugs
- (2016) Mallory A. Havens et al. NUCLEIC ACIDS RESEARCH
- Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK -Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization
- (2016) Siraj M. Ali et al. ONCOLOGIST
- Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma
- (2016) Patrick J. Grohar et al. Cell Reports
- Identifying fusion transcripts using next generation sequencing
- (2016) Shailesh Kumar et al. Wiley Interdisciplinary Reviews-RNA
- The nuts and bolts of the endogenous spliceosome
- (2016) Ruth Sperling Wiley Interdisciplinary Reviews-RNA
- Antisense oligonucleotides in therapy for neurodegenerative disorders
- (2015) Melvin M. Evers et al. ADVANCED DRUG DELIVERY REVIEWS
- Oligonucleotide therapeutics: chemistry, delivery and clinical progress
- (2015) Vivek K Sharma et al. Future Medicinal Chemistry
- The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains
- (2015) Artyom A. Alekseyenko et al. GENES & DEVELOPMENT
- Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes
- (2015) Fredrik Mertens et al. GENES CHROMOSOMES & CANCER
- Decoding of exon splicing patterns in the human RUNX1–RUNX1T1 fusion gene
- (2015) Vasily V. Grinev et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Genomics in acute lymphoblastic leukaemia: insights and treatment implications
- (2015) Kathryn G. Roberts et al. Nature Reviews Clinical Oncology
- The oncogene ERG: a key factor in prostate cancer
- (2015) P Adamo et al. ONCOGENE
- Landscape of gene fusions in epithelial cancers: seq and ye shall find
- (2015) Chandan Kumar-Sinha et al. Genome Medicine
- Quantitative Analysis of ERG Expression and Its Splice Isoforms in Formalin-Fixed, Paraffin-Embedded Prostate Cancer Samples
- (2014) Rachel M. Hagen et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Recurrent read-through fusion transcripts in breast cancer
- (2014) Katherine E. Varley et al. BREAST CANCER RESEARCH AND TREATMENT
- A systematic description of MLL fusion gene formation
- (2014) Rebecca L. Wright et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Chimeric RNAs generated by intergenic splicing in normal and cancer cells
- (2014) Kasey Jividen et al. GENES CHROMOSOMES & CANCER
- Mechanistic Analysis of the Role of Bromodomain-containing Protein 4 (BRD4) in BRD4-NUT Oncoprotein-induced Transcriptional Activation
- (2014) Ranran Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Genomic Landscape of Pediatric Ewing Sarcoma
- (2014) B. D. Crompton et al. Cancer Discovery
- Dynamic Integration of Splicing within Gene Regulatory Pathways
- (2013) Ulrich Braunschweig et al. CELL
- Genomic EWS-FLI1 Fusion Sequences in Ewing Sarcoma Resemble Breakpoint Characteristics of Immature Lymphoid Malignancies
- (2013) Manfred Berger et al. PLoS One
- Multiple splice variants of EWSR1-ETS fusion transcripts co-existing in the Ewing sarcoma family of tumors
- (2013) Barbara Patócs et al. CELLULAR ONCOLOGY
- RNA-Based Therapeutics: Current Progress and Future Prospects
- (2012) John C. Burnett et al. CHEMISTRY & BIOLOGY
- Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants
- (2012) J. M. Heuckmann et al. CLINICAL CANCER RESEARCH
- Alternative splicing: decoding an expansive regulatory layer
- (2012) Manuel Irimia et al. CURRENT OPINION IN CELL BIOLOGY
- Novel BRD4–NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma
- (2012) K Thompson-Wicking et al. ONCOGENE
- Chromosomal aberrations and fusion genes in myeloid malignancies
- (2012) Valentina Gianfelici et al. Expert Review of Hematology
- Chimeric Transcript Generated by cis-Splicing of Adjacent Genes Regulates Prostate Cancer Cell Proliferation
- (2012) Yanmei Zhang et al. Cancer Discovery
- Exon and intron definition in pre-mRNA splicing
- (2012) Laura De Conti et al. Wiley Interdisciplinary Reviews-RNA
- AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
- (2012) Megan A. Hatlen et al. Frontiers of Medicine
- Pathogenesis of NUT Midline Carcinoma
- (2011) Christopher A. French Annual Review of Pathology-Mechanisms of Disease
- The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia
- (2011) T. O'Hare et al. BLOOD
- NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights
- (2011) S. M. Gough et al. BLOOD
- Gene fusions and RNA trans-splicing in normal and neoplastic human cells
- (2011) Hui Li et al. CELL CYCLE
- RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis
- (2011) Kentson Lam Frontiers in Bioscience-Landmark
- Perturbation of BRD4 Protein Function by BRD4-NUT Protein Abrogates Cellular Differentiation in NUT Midline Carcinoma
- (2011) Junpeng Yan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations?
- (2011) Franz X. Gruber et al. MEDICAL ONCOLOGY
- Promiscuous partnerships in Ewing's sarcoma
- (2011) Savita Sankar et al. Cancer Genetics
- Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains
- (2010) Nicolas Reynoird et al. EMBO JOURNAL
- The biology and treatment of EML4-ALK non-small cell lung cancer
- (2010) Takaaki Sasaki et al. EUROPEAN JOURNAL OF CANCER
- Functional Activity of the OCT-1 Protein Is Predictive of Long-Term Outcome in Patients With Chronic-Phase Chronic Myeloid Leukemia Treated With Imatinib
- (2010) Deborah L. White et al. JOURNAL OF CLINICAL ONCOLOGY
- A novel exon in AML1-ETO negatively influences the clonogenic potential of the t(8;21) in acute myeloid leukemia
- (2010) D Mannari et al. LEUKEMIA
- Expansion of the eukaryotic proteome by alternative splicing
- (2010) Timothy W. Nilsen et al. NATURE
- Alternative splicing and evolution: diversification, exon definition and function
- (2010) Hadas Keren et al. NATURE REVIEWS GENETICS
- Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
- (2010) Eunice L. Kwak et al. NEW ENGLAND JOURNAL OF MEDICINE
- BCR-ABL Truncation due to Premature Translation Termination as a Mechanism of Resistance to Kinase Inhibitors
- (2009) Wanlong Ma et al. ACTA HAEMATOLOGICA
- The Discovery of Common Recurrent Transmembrane Protease Serine 2 (TMPRSS2)-Erythroblastosis Virus E26 Transforming Sequence (ETS) Gene Fusions in Prostate Cancer
- (2009) Rajal B. Shah et al. ADVANCES IN ANATOMIC PATHOLOGY
- Patterns of exon-intron architecture variation of genes in eukaryotic genomes
- (2009) Liucun Zhu et al. BMC GENOMICS
- Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non–small cell lung carcinomas
- (2009) Jennifer M. Boland et al. HUMAN PATHOLOGY
- Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK
- (2009) Alice T. Shaw et al. JOURNAL OF CLINICAL ONCOLOGY
- Flow cytometric immunobead assay for the detection of BCR–ABL fusion proteins in leukemia patients
- (2009) F Weerkamp et al. LEUKEMIA
- Human Splicing Finder: an online bioinformatics tool to predict splicing signals
- (2009) François-Olivier Desmet et al. NUCLEIC ACIDS RESEARCH
- Therapeutic Potential of Splice-Switching Oligonucleotides
- (2009) John Bauman et al. OLIGONUCLEOTIDES
- European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor
- (2008) D. Marin et al. BLOOD
- Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non-Small Cell Lung Cancer
- (2008) Y. L. Choi et al. CANCER RESEARCH
- Pleiotropic Biological Activities of Alternatively Spliced TMPRSS2/ERG Fusion Gene Transcripts
- (2008) J. Wang et al. CANCER RESEARCH
- Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts
- (2008) K. Takeuchi et al. CLINICAL CANCER RESEARCH
- Delineation of TMPRSS2-ERG Splice Variants in Prostate Cancer
- (2008) Y. Hu et al. CLINICAL CANCER RESEARCH
- An Intron-Derived Insertion/Truncation Mutation in the BCR-ABL Kinase Domain in Chronic Myeloid Leukemia Patients Undergoing Kinase Inhibitor Therapy
- (2008) Jennifer Laudadio et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- BCR-ABL alternative splicing as a common mechanism for imatinib resistance: evidence from molecular dynamics simulations
- (2008) T.-S. Lee et al. MOLECULAR CANCER THERAPEUTICS
- Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
- (2008) Qun Pan et al. NATURE GENETICS
- Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia: a report from the Children's Oncology Group
- (2008) K M LaFiura et al. ONCOGENE
- Complementing mutations in core binding factor leukemias: from mouse models to clinical applications
- (2008) A M S Müller et al. ONCOGENE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation