Article
Oncology
Yingchun Liang, Enlin Rong, Jin Qian, Chenkai Ma, Jimeng Hu
Summary: In this study, the researchers analyzed the transcriptome of 231 patients with metastatic prostate cancer and identified four distinct biological subtypes. They found that the luminal subtype had higher androgen receptor expression and copy number alterations, while genes in the HRR pathway were downregulated in most subtypes except HRR and NE subtypes. The researchers also found that the basal subtype had a higher frequency of the TMPRSS2-ERG fusion.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Qiong Wang, Junxiu Chen, Sandeep Singh, Zhongqiu Xie, Fujun Qin, Xinrui Shi, Robert Cornelison, Hui Li, Hai Huang
Summary: This study examined the landscape of chimeric RNAs in different types of prostate cancer cell lines and identified chimeric RNAs specifically expressed in neuroendocrine prostate cancer (NEPC). Experimental validation and in silico analysis showed that these chimeric RNAs may serve as biomarkers for tumor malignancy and poor clinical prognosis.
CELL AND BIOSCIENCE
(2022)
Article
Multidisciplinary Sciences
Eva Shrestha, Jonathan B. Coulter, William Guzman, Busra Ozbek, Megan M. Hess, Luke Mummert, Sarah E. Ernst, Janielle P. Maynard, Alan K. Meeker, Christopher M. Heaphy, Michael C. Haffner, Angelo M. De Marzo, Karen S. Sfanos
Summary: The study suggests that bacterial infections may initiate driver gene alterations in prostate cancer, with infection-induced ERG+ fusions being an early alteration in the carcinogenic process, potentially originating from proliferative inflammatory atrophy as a precursor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Yusuph Mavura, Hanbing Song, Jamie Xie, Pablo Tamayo, Abdullahi Mohammed, Ahmad T. Lawal, Ahmad Bello, Sani Ibrahim, Mohammed Faruk, Franklin W. Huang
Summary: Men of African ancestry have a higher incidence and mortality rate of prostate cancer. This study analyzed the transcriptome of Nigerian men with prostate cancer and found that ETS fusion events, such as TMPRSS2-ETV5, were more common than previously thought. The study also developed gene set signatures for Nigerian prostate cancer.
Review
Biochemistry & Molecular Biology
Ealia Khosh Kish, Muhammad Choudhry, Yaser Gamallat, Sabrina Marsha Buharideen, D. Dhananjaya, Tarek A. Bismar
Summary: The ERG gene is consistently overexpressed in prostate cancer and is mainly due to the fusion of ERG and TMPRSS2 genes. ERG enhances tumor growth by promoting inflammatory and angiogenic responses and is involved in the epithelial-mesenchymal transition, increasing the metastatic ability of prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Longjiang Shao, Jianghua Wang, Omer Karatas, Michael Ittmann
Summary: The study found that in prostate cancer, MEX3D and TCF3 are correlated, and their expression is influenced by decreased PTEN and expression of the TE fusion gene, promoting transformation through certain pathways.
Article
Oncology
Ying Z. Mazzu, YuRou Liao, Subhiksha Nandakumar, Martin Sjostrom, Lina E. Jehane, Romina Ghale, Barani Govindarajan, Travis A. Gerke, Gwo-Shu Mary Lee, Jian-Hua Luo, Sreenivasa R. Chinni, Lorelei A. Mucci, Felix Y. Feng, Philip W. Kantoff
Summary: This study reveals the epigenetic silencing of the SNAI2 gene in prostate cancer and its correlation with disease progression and treatment sensitivity, and suggests a new therapeutic strategy by restoring SNAI2 expression.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Komal Raina, Rama Kant, Ram R. Prasad, Kushal Kandhari, Munendra Tomar, Neha Mishra, Robin Kumar, Jennifer T. Fox, Shizuko Sei, Robert H. Shoemaker, Yu Chen, Paul Maroni, Chapla Agarwal, Rajesh Agarwal
Summary: This study compared the pathological and molecular markers of TMPRSS2-ERG fusion and PTEN loss-driven versus non-fusion-driven prostate tumorigenesis in mice. The results showed that both mouse models exhibited growth and progression of prostate intraepithelial lesions to adenocarcinoma stages, although at different rates. The TMPRSS2-ERG. Pten(flox/flox) mice had slower initiation of tumorigenesis but faster progression through different stages, while the Hi-Myc(+/)(-) mice had rapid initiation but slower progression. Additionally, high-grade undifferentiated tumors were observed in the Hi-Myc(+/)(-) mice at advanced stages compared to the fusion-driven TMPRSS2-ERG. Pten(flox/flox) mice.
MOLECULAR CARCINOGENESIS
(2022)
Article
Multidisciplinary Sciences
Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat
Summary: Mutually exclusive prostate cancer driver alterations involving ERG transcription factor and ubiquitin ligase adaptor SPOP have synthetic sick effects, regulating the response to therapeutic interventions in the AR pathway. This dichotomy highlights a distinct class of antagonistic cancer drivers and provides a blueprint for therapeutic exploitation.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Anastasiya A. Kobelyatskaya, Elena A. Pudova, Anastasiya Snezhkina, Maria S. Fedorova, Vladislav S. Pavlov, Zulfiya G. Guvatova, Maria Savvateeva, Nataliya Melnikova, Alexey A. Dmitriev, Dmitry Y. Trofimov, Gennady T. Sukhikh, Kirill M. Nyushko, Boris Y. Alekseev, Sergey Razin, George S. Krasnov, Anna Kudryavtseva
Summary: The study found contradictory results regarding the association between the TMPRSS2-ERG transcript and biochemical recurrence in PCa. Differential expression analysis and gene set enrichment analysis revealed genes involved in major cellular pathways. GNL3, QSOX2, SSPO, and SYS1 genes were selected as predictors for a potential prognostic model, with AUC values of 1.000 for the Russian PCa cohort and 0.779 for the TCGA-PRAD cohort.
Article
Oncology
Massimo Lazzeri, Vittorio Fasulo, Giovanni Lughezzani, Alessio Benetti, Giulia Solda, Rosanna Asselta, Ilaria De Simone, Marco Paciotti, Pier Paolo Avolio, Roberto Contieri, Cesare Saitta, Alberto Saita, Rodolfo Hurle, Giorgio Guazzoni, Nicolo Maria Buffi, Paolo Casale
Summary: This study aimed to test the relationship between a specific genetic lesion and imaging scores, and to assess their effectiveness for the diagnosis of prostate cancer. The results showed that T2:ERG translocation and imaging results are independent of each other, but both are related to clinically significant prostate cancer. Using both T2:ERG detection and imaging techniques together can improve the accuracy of diagnosing prostate cancer and clinically significant prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Mauro Scaravilli, Sonja Koivukoski, Leena Latonen
Summary: Androgens and their receptor play crucial roles in various diseases, particularly in prostate cancer. Genetic fusions regulated by androgens are more common in prostate cancer compared to other tumors, raising questions that require further investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elena Fountzilas, Maria Kouspou, Alexia Eliades, Kyriaki Papadopoulou, Evangelos Bournakis, Anna Goussia, Marinos Tsiatas, Achilleas Achilleos, Kyriakos Tsangaras, Gaetan Billioud, Charalambos Loizides, Christos Lemesios, Elena Kypri, Marios Ioannides, George Koumbaris, Sofia Levva, Ioannis Vakalopoulos, Athanasios Paliouras, Stavroula Pervana, Filippos Koinis, Redi Bumci, Athina Christopoulou, Soultana Meditskou, Amanda Psyrri, Ioannis Boukovinas, Anastasios Visvikis, Vasilios Karavasilis, George K. K. Koukoulis, Athanasios Kotsakis, Dimitrios Giannakis, George Fountzilas, Philippos C. C. Patsalis
Summary: The data on tumor molecular profiling of European patients with prostate cancer is limited. Our study aimed to assess the prevalence and significance of gene alterations in unselected patients with prostate cancer. We found that clinically relevant somatic gene alterations were present in a significant proportion of European patients with prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Kit Man Chan, Jonathan M. Gleadle, Michael O'Callaghan, Krasimir Vasilev, Melanie MacGregor
Summary: The review highlights the potential of urinary biosensors for non-invasive prostate cancer detection, but large-scale trials are needed to validate these approaches. Clinical studies have shown good discrimination between prostate cancer patients and controls, but more research is needed to address the ability of these biosensors to differentiate between aggressive and indolent cancer.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
Donglin Ding, Alexandra M. Blee, Jianong Zhang, Yunqian Pan, Nicole A. Becker, L. James Maher, Rafael Jimenez, Liguo Wang, Haojie Huang
Summary: This study demonstrates that TP53 gene alteration and TMPRSS2-ERG fusion act together to promote prostate cancer development. Gain-of-function mutant p53 is shown to bind to a specific DNA sequence in the CTNNB1 gene promoter and activate its expression. ERG and β-Catenin co-occupy sites at pyrimidine synthesis gene loci and promote pyrimidine synthesis and prostate cancer growth. Inhibition of β-Catenin suppresses the growth of TMPRSS2-ERG and p53 mutant-positive prostate cancer cells in vitro and in mice.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Claire M. Perks, H. A. Zielinska, Jing Wang, Caroline Jarrett, A. Frankow, Michael R. Ladomery, Amit Bahl, Anthony Rhodes, Jon Oxley, Jeff M. P. Holly
FRONTIERS IN ENDOCRINOLOGY
(2016)
Article
Oncology
Lee Fah Yap, Sook Ling Lai, Anthony Rhodes, Hans Prakash Sathasivam, Maizaton Atmadini Abdullah, Kin-Choo Pua, Pathmanathan Rajadurai, Phaik-Leng Cheah, Selvam Thavaraj, Max Robinson, Ian C. Paterson
INFECTIOUS AGENTS AND CANCER
(2018)
Article
Pathology
Sarah J. R. Dean, Claire M. Perks, Jeff M. P. Holly, Nirmala Bhoo-Pathy, Lai-Meng Looi, Nur Aishah Taib Mohammed, Kein-Seong Mun, Soo-Hwang Teo, Moses O. Koobotse, Cheng-Har Yip, Anthony Rhodes
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2014)
Article
Oncology
Char-Hong Ng, Nirmala Bhoo Pathy, Nur Aishah Taib, Gwo-Fuang Ho, Kein-Seong Mun, Anthony Rhodes, Lai-Meng Looi, Cheng-Har Yip
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
(2014)
Article
Pharmacology & Pharmacy
Bahareh Vahabi, Brian A. Parsons, Olena Doran, Anthony Rhodes, Sarah Dean, Marcus J. Drake
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2013)
Article
Pathology
Rachel M. Hagen, Anthony Rhodes, Jon Oxley, Michael R. Ladomery
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2013)
Review
Oncology
Cheng-Har Yip, Anthony Rhodes
Article
Pathology
Jia Shin Jessica Tan, Kien Chai Ong, Diana Bee-Lan Ong, Azad Razack, Jasmine Lim, Rosna Yunus, Murali Sundram, Anthony Rhodes
MALAYSIAN JOURNAL OF PATHOLOGY
(2018)
Article
Medical Laboratory Technology
Anthony Rhodes, Narayanan Vallikkannu, Pailoor Jayalakshmi
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2017)
Review
Pathology
Jia Shin Jessica Tan, Kien Chai Ong, Anthony Rhodes
MALAYSIAN JOURNAL OF PATHOLOGY
(2016)
Review
Pathology
Sarah J. R. Dean, Anthony Rhodes
MALAYSIAN JOURNAL OF PATHOLOGY
(2014)
Article
Oncology
Rachel M. Hagen, Anthony Rhodes, Michael R. Ladomery
ANTICANCER RESEARCH
(2013)
Article
Oncology
Sze-Yee Phuah, Lai-Meng Looi, Norhashimah Hassan, Anthony Rhodes, Sarah Dean, Nur Aishah Mohd Taib, Cheng-Har Yip, Soo-Hwang Teo
BREAST CANCER RESEARCH
(2012)
Article
Medical Laboratory Technology
N. Mohamad, P. Jayalakshmi, A. Rhodes, C-K Liam, J-L Tan, S. Yousoof, P. Rajadurai
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2017)