C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM

(2017) Yi Zhou et al.   MOLECULAR CELL

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency

(2017) Ragini Bhargava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

(2017) Alex N. Zelensky et al.   Nature Communications

Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes

(2016) Putzer J. Hung et al.   CELL CYCLE

Allosteric communication pipelines in G-protein-coupled receptors

(2016) Nagarajan Vaidehi et al.   CURRENT OPINION IN PHARMACOLOGY

Synthetic lethality between PAXX and XLF in mammalian development

(2016) Gabriel Balmus et al.   GENES & DEVELOPMENT

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

(2016) Howard H. Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved Mechanism of Conformational Stability and Dynamics in G-Protein-Coupled Receptors

(2016) Supriyo Bhattacharya et al.   Journal of Chemical Theory and Computation

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

(2016) Thomas G.W. Graham et al.   MOLECULAR CELL

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

(2016) David W. Wyatt et al.   MOLECULAR CELL

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

(2016) Ineke Brouwer et al.   NATURE

PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line

(2016) Vipul Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers

(2016) Christopher D. Putnam et al.   Nature Communications

Mutational signatures of ionizing radiation in second malignancies

(2016) Sam Behjati et al.   Nature Communications

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

(2016) Satish K. Tadi et al.   Cell Reports

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

(2016) Chloé Lescale et al.   Cell Reports

Linking DNA polymerase theta structure and function in health and disease

(2015) Kelly Beagan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation

(2015) Sunetra Roy et al.   MOLECULAR AND CELLULAR BIOLOGY

Akt-Mediated Phosphorylation of XLF Impairs Non-Homologous End-Joining DNA Repair

(2015) Pengda Liu et al.   MOLECULAR CELL

Differences in Allosteric Communication Pipelines in the Inactive and Active States of a GPCR

(2014) Supriyo Bhattacharya et al.   BIOPHYSICAL JOURNAL

Nonhomologous end joining: A good solution for bad ends

(2014) Crystal A. Waters et al.   DNA REPAIR

The spatial organization of non-homologous end joining: From bridging to end joining

(2014) Takashi Ochi et al.   DNA REPAIR

Non-homologous end joining often uses microhomology: Implications for alternative end joining

(2014) Nicholas R. Pannunzio et al.   DNA REPAIR

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

(2014) Hind Ghezraoui et al.   MOLECULAR CELL

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining

(2014) Crystal A. Waters et al.   Nature Communications

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

A human XRCC4–XLF complex bridges DNA

(2012) Sara N. Andres et al.   NUCLEIC ACIDS RESEARCH

Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development

(2012) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF

(2011) Ken-ichi Yano et al.   FEBS LETTERS

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

(2010) Cristian Boboila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential

(2009) Nicole Bennardo et al.   PLoS Genetics

Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination

(2008) Gang Li et al.   MOLECULAR CELL

Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

(2008) Kihoon Lee et al.   NATURE

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics