Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection

In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment

(2018) Paolo Gaibani et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Multidrug efflux pumps: structure, function and regulation

(2018) Dijun Du et al.   NATURE REVIEWS MICROBIOLOGY

High mutation rates limit evolutionary adaptation in Escherichia coli

(2018) Kathleen Sprouffske et al.   PLoS Genetics

Identifying and exploiting genes that potentiate the evolution of antibiotic resistance

(2018) Danna R. Gifford et al.   Nature Ecology & Evolution

Antibiotic-Induced Genetic Variation: How It Arises and How It Can Be Prevented

(2018) Jesús Blázquez et al.   Annual Review of Microbiology

Mutation-Driven Evolution of Pseudomonas aeruginosa in the Presence of either Ceftazidime or Ceftazidime-Avibactam

(2018) Fernando Sanz-García et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Loss of activity of ceftazidime-avibactam due to Mex-AB-OprM efflux and overproduction of AmpC cephalosporinase in Pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis

(2018) Hussein Chalhoub et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

(2017) Peter Jorth et al.   mBio

The rapid in vivo evolution of Pseudomonas aeruginosa in ventilator-associated pneumonia patients leads to attenuated virulence

(2017) Ke Wang et al.   Open Biology

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

(2017) Sofie V. Nielsen et al.   PLoS Genetics

Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates

(2016) Gabriel Cabot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The properties of spontaneous mutations in the opportunistic pathogen Pseudomonas aeruginosa

(2016) Jeremy R. Dettman et al.   BMC GENOMICS

Bacterial proteases, untapped antimicrobial drug targets

(2016) Elizabeth Culp et al.   JOURNAL OF ANTIBIOTICS

Genetic drift, selection and the evolution of the mutation rate

(2016) Michael Lynch et al.   NATURE REVIEWS GENETICS

Environmentally Endemic Pseudomonas aeruginosa Strains with Mutations in lasR Are Associated with Increased Disease Severity in Corneal Ulcers

(2016) John H. Hammond et al.   mSphere

First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate

(2015) Romney M. Humphries et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroSelection of Ceftazidime-Avibactam Resistance in Enterobacteriaceae with KPC-3 Carbapenemase

(2015) David M. Livermore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC

(2015) S. D. Lahiri et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years

(2015) Timothy J. Kidd et al.   Journal of Cystic Fibrosis

Pseudomonas aeruginosa Ceftolozane-Tazobactam Resistance Development Requires Multiple Mutations Leading to Overexpression and Structural Modification of AmpC

(2014) Gabriel Cabot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations

(2014) Jingjing Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome sequencing and characterization of an extensively drug-resistant sequence type 111 serotype O12 hospital outbreak strain of Pseudomonas aeruginosa

(2014) A.A. Witney et al.   CLINICAL MICROBIOLOGY AND INFECTION

Microbiological effects of sublethal levels of antibiotics

(2014) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome

(2013) Juana V. Martín-López et al.   Familial Cancer

β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

(2013) A. Gutierrez et al.   Nature Communications

Sequence-Verified Two-Allele Transposon Mutant Library for Pseudomonas aeruginosa PAO1

(2012) Kiara Held et al.   JOURNAL OF BACTERIOLOGY

Pseudomonas aeruginosa Exhibits Frequent Recombination, but Only a Limited Association between Genotype and Ecological Setting

(2012) Timothy J. Kidd et al.   PLoS One

General and inducible hypermutation facilitate parallel adaptation in Pseudomonas aeruginosa despite divergent mutation spectra

(2012) M. R. Weigand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing

(2012) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Intracellular Proteases in the Antibiotic Resistance, Motility, and Biofilm Formation of Pseudomonas aeruginosa

(2011) Lucía Fernández et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Competition between high- and higher-mutating strains of Escherichia coli

(2011) C. F. Gentile et al.   Biology Letters

Bacterial hypermutation in cystic fibrosis, not only for antibiotic resistance

(2010) A. Oliver et al.   CLINICAL MICROBIOLOGY AND INFECTION

Evolution of the mutation rate

(2010) Michael Lynch   TRENDS IN GENETICS

Extended-Spectrum Cephalosporinases in Pseudomonas aeruginosa

(2009) J.-M. Rodriguez-Martinez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa

(2009) Gaby Sennhauser et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutations in the Conserved Glycine and Serine of the MutS ABC signature motif affect Nucleotide Exchange, Kinetics of sliding clamp release of mismatch and mismatch repair

(2009) Samir Acharya et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS