Mutation-Driven Evolution of Pseudomonas aeruginosa in the Presence of either Ceftazidime or Ceftazidime-Avibactam

Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation

(2018) Mengyu Shen et al.   NUCLEIC ACIDS RESEARCH

Identifying and exploiting genes that potentiate the evolution of antibiotic resistance

(2018) Danna R. Gifford et al.   Nature Ecology & Evolution

Activity of ceftazidime–avibactam against multidrug-resistance Enterobacteriaceae expressing combined mechanisms of resistance

(2017) Inmaculada López-Hernández et al.   ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA

Mechanisms leading to in vivo ceftolozane/tazobactam resistance development during the treatment of infections caused by MDR Pseudomonas aeruginosa

(2017) Pablo A Fraile-Ribot et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

(2017) Karina Calvopiña et al.   MOLECULAR MICROBIOLOGY

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

(2017) Peter Jorth et al.   mBio

History of antibiotic adaptation influences microbial evolutionary dynamics during subsequent treatment

(2017) Phillip Yen et al.   PLOS BIOLOGY

Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone

(2017) Carla López-Causapé et al.   Scientific Reports

Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates

(2016) Gabriel Cabot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Overexpression of MexAB-OprM efflux pump in carbapenem-resistant Pseudomonas aeruginosa

(2016) Ya-ping Pan et al.   ARCHIVES OF MICROBIOLOGY

In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa

(2016) Cristian Gustavo Aguilera Rossi et al.   BMC MICROBIOLOGY

The Approach to Pseudomonas aeruginosa in Cystic Fibrosis

(2016) Jaideep S. Talwalkar et al.   CLINICS IN CHEST MEDICINE

Pyomelanin-producing Pseudomonas aeruginosa selected during chronic infections have a large chromosomal deletion which confers resistance to pyocins

(2016) Didier Hocquet et al.   ENVIRONMENTAL MICROBIOLOGY

High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations

(2016) Hussein Chalhoub et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Increase of efflux-mediated resistance in Pseudomonas aeruginosa during antibiotic treatment in patients suffering from nosocomial pneumonia

(2016) Mickaël Riou et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition againstPseudomonas aeruginosa

(2016) Myriam Hamou-Segarra et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated intra-abdominal infections

(2016) Celeste Vinluan et al.   Drug Design Development and Therapy

Activity of Ceftazidime-Avibactam against Fluoroquinolone-Resistant Enterobacteriaceae and Pseudomonas aeruginosa

(2015) C. Pitart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

(2015) Vincent M. Isabella et al.   CHEMISTRY & BIOLOGY

The increasing threat of Pseudomonas aeruginosa high-risk clones

(2015) Antonio Oliver et al.   DRUG RESISTANCE UPDATES

Ceftolozane/tazobactam and ceftazidime/avibactam: two novel β-lactam/β-lactamase inhibitor combination agents for the treatment of resistant Gram-negative bacterial infections

(2015) Jordan L. Liscio et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity

(2015) Jessica M. A. Blair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa in vitroPhenotypes Distinguish Cystic Fibrosis Infection Stages and Outcomes

(2014) Nicole Mayer-Hamblett et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

β-Lactam/β-Lactamase Inhibitor Combinations

(2014) Kimberly A. Toussaint et al.   ANNALS OF PHARMACOTHERAPY

Mutation-Driven β-Lactam Resistance Mechanisms among Contemporary Ceftazidime-Nonsusceptible Pseudomonas aeruginosa Isolates from U.S. Hospitals

(2014) Mariana Castanheira et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Resistome of Pseudomonas aeruginosa in Relationship to Phenotypic Susceptibility

(2014) Veronica N. Kos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ceftazidime-Avibactam: a Novel Cephalosporin/β-lactamase Inhibitor Combination

(2013) George G. Zhanel et al.   DRUGS

The Pseudomonas aeruginosa Periplasmic Protease CtpA Can Affect Systems That Impact Its Ability To Mount Both Acute and Chronic Infections

(2013) Jin Seo et al.   INFECTION AND IMMUNITY

Genetic Markers of Widespread Extensively Drug-Resistant Pseudomonas aeruginosa High-Risk Clones

(2012) Gabriel Cabot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Carbapenemases in Klebsiella pneumoniae and Other Enterobacteriaceae: an Evolving Crisis of Global Dimensions

(2012) L. S. Tzouvelekis et al.   CLINICAL MICROBIOLOGY REVIEWS

Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment

(2012) Martin H. Rau et al.   ENVIRONMENTAL MICROBIOLOGY

Genomics of Adaptation during Experimental Evolution of the Opportunistic Pathogen Pseudomonas aeruginosa

(2012) Alex Wong et al.   PLoS Genetics

CTX-M Enzymes: Origin and Diffusion

(2012) Rafael Cantón et al.   Frontiers in Microbiology

Antagonistic Interactions of Pseudomonas aeruginosa Antibiotic Resistance Mechanisms in Planktonic but Not Biofilm Growth

(2011) Xavier Mulet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Intracellular Proteases in the Antibiotic Resistance, Motility, and Biofilm Formation of Pseudomonas aeruginosa

(2011) Lucía Fernández et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors

(2011) Ken Coleman   CURRENT OPINION IN MICROBIOLOGY

In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae

(2011) Z. Aktaş et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The intrinsic resistome ofPseudomonas aeruginosato β-lactams

(2011) Carolina Alvarez-Ortega et al.   Virulence

Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code

(2010) A. Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic Determinants Involved in the Susceptibility of Pseudomonas aeruginosa to  -Lactam Antibiotics

(2010) C. Alvarez-Ortega et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential  -lactam resistance response driven by ampD or dacB (PBP4) inactivation in genetically diverse Pseudomonas aeruginosa strains

(2010) L. Zamorano et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Inactivation of the hmgA gene of Pseudomonas aeruginosa leads to pyomelanin hyperproduction, stress resistance and increased persistence in chronic lung infection

(2009) A. Rodriguez-Rojas et al.   MICROBIOLOGY-SGM

ChronicPseudomonas aeruginosaInfection in Chronic Obstructive Pulmonary Disease

(2008) Laura Martínez‐Solano et al.   CLINICAL INFECTIOUS DISEASES

Clinical Impact of the Over-Expression of Efflux Pump in Nonfermentative Gram-Negative Bacilli, Development of Efflux Pump Inhibitors

(2008) Jordi Vila et al.   CURRENT DRUG TARGETS

The Neglected Intrinsic Resistome of Bacterial Pathogens

(2008) Alicia Fajardo et al.   PLoS One