Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue

Molecular targets and pathways for the treatment of visceral leishmaniasis

(2018) Vineet Jain et al.   DRUG DISCOVERY TODAY

Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat

(2018) Wei-Lun Hung et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Neglected Tropical Diseases, Neglected Communities, and Conflict: How Do We Leave No One Behind?

(2018) Julie Jacobson et al.   TRENDS IN PARASITOLOGY

Bioactive flavonoids in medicinal plants: Structure, activity and biological fate

(2018) Tian-yang Wang et al.   Asian Journal of Pharmaceutical Sciences

Recent discoveries of anticancer flavonoids

(2017) Demetrio Raffa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro antileishmanial activity of fisetin flavonoid via inhibition of glutathione biosynthesis and arginase activity in Leishmania infantum

(2017) Keivan Adinehbeigi et al.   Pathogens and Global Health

Prevention and Control Strategies to Counter Dengue Virus Infection

(2017) Irfan A. Rather et al.   Frontiers in Cellular and Infection Microbiology

The citrus flavanone naringenin impairs dengue virus replication in human cells

(2017) Sandra Frabasile et al.   Scientific Reports

Individual and combined antiparasitic effect of six plant metabolites against Leishmania amazonensis and Trypanosoma cruzi

(2016) Louis P. Sandjo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH)

(2016) Naomi Aronson et al.   CLINICAL INFECTIOUS DISEASES

An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever

(2016) Chelsea N. Powers et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Flavonoids and Chagas'; Disease: The Story So Far!

(2016) Seyed Fazel Nabavi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Quercetin derivatives as non-nucleoside inhibitors for dengue polymerase: molecular docking, molecular dynamics simulation, and binding free energy calculation

(2016) Shanmugam Anusuya et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians

(2016) Emeline Houël et al.   JOURNAL OF ETHNOPHARMACOLOGY

A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani

(2016) P. Vacchina et al.   Parasites & Vectors

Trypanocidal and leishmanicidal activities of flavonoids isolated fromStevia satureiifoliavar.satureiifolia

(2016) María Florencia Beer et al.   PHARMACEUTICAL BIOLOGY

Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action

(2016) Fernanda Fonseca-Silva et al.   PLoS Neglected Tropical Diseases

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

(2016) Annelies Mondelaers et al.   PLoS One

HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda

(2016) Daniel J. Kyabayinze et al.   PLoS One

Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia

(2015) AGB Azebaze et al.   African Health Sciences

Cutaneous Leishmaniasis: Recent Developments in Diagnosis and Management

(2015) Henry J. C. de Vries et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies

(2015) Lorena Ramos Freitas de Sousa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs

(2015) Travis R. Helgren et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana

(2015) Lorena R.F. de Sousa et al.   EXPERIMENTAL PARASITOLOGY

Metabolic reconfiguration of the central glucose metabolism: a crucial strategy of Leishmania donovani for its survival during oxidative stress

(2015) Ayan K. Ghosh et al.   FASEB JOURNAL

Protective activity of biflavanones from Garcinia kola against Plasmodium infection

(2015) Benetode Konziase   JOURNAL OF ETHNOPHARMACOLOGY

Targeting Polyamine Metabolism for Finding New Drugs Against Leishmaniasis: A Review

(2015) Andrea Ilari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species

(2015) Haribalan Perumalsamy et al.   Parasites & Vectors

Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum

(2015) Paula S. Lage et al.   PARASITOLOGY RESEARCH

American tegumentary leishmaniasis: correlations among immunological, histopathological and clinical parameters

(2014) Ana Luiza Grizzo Peres Martins et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

In VitroandIn VivoEfficacy of Novel Flavonoid Dimers against Cutaneous Leishmaniasis

(2014) Iris L. K. Wong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Flavones: An important scaffold for medicinal chemistry

(2014) Manjinder Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dietary flavonoids fisetin and myricetin: Dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II

(2014) Huangtao Jin et al.   FITOTERAPIA

Leishmanicidal compounds and potent PPARγ activators from Renealmia thyrsoidea (Ruiz & Pav.) Poepp. & Endl.

(2014) Billy Joel Cabanillas et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dimeric Flavonoids from Arrabidaea brachypoda and Assessment of Their Anti-Trypanosoma cruzi Activity

(2014) Cláudia Quintino da Rocha et al.   JOURNAL OF NATURAL PRODUCTS

In vitro activity of the hydroethanolic extract and biflavonoids isolated from Selaginella sellowii on Leishmania (Leishmania) amazonensis

(2014) Yasmin Silva Rizk et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis

(2014) Elly Montrieux et al.   PARASITOLOGY RESEARCH

Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum

(2014) I. C. Ezenyi et al.   PARASITOLOGY RESEARCH

Pharmacokinetic study of rutin and quercetin in rats after oral administration of total flavones of mulberry leaf extract

(2014) Zhen Ou-yang et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice

(2014) Adaramoye Oluwatosin et al.   Asian Pacific Journal of Tropical Medicine

Baicalin, a metabolite of baicalein with antiviral activity against dengue virus

(2014) Ehsan Moghaddam et al.   Scientific Reports

The Effect of (-)-Epigallocatechin 3-O - Gallate In Vitro and In Vivo in Leishmania braziliensis: Involvement of Reactive Oxygen Species as a Mechanism of Action

(2014) Job D. F. Inacio et al.   PLoS Neglected Tropical Diseases

Rational Discovery of Dengue Type 2 Non-Competitive Inhibitors

(2013) Choon H. Heh et al.   Chemical Biology & Drug Design

An automatic algorithm for the detection of Trypanosoma cruzi parasites in blood sample images

(2013) Roger Soberanis-Mukul et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

(2013) Tiago Rodrigues et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection

(2013) Leticia Correa Manjolin et al.   FOOD CHEMISTRY

Structural insights of SIR2rp3 proteins as promising biotargets to fight against Chagas disease and leishmaniasis

(2013) Lionel Sacconnay et al.   Molecular BioSystems

Design and exploratory data analysis of a second generation of dendrimer prodrugs potentially antichagasic and leishmanicide

(2013) Jeanine Giarolla et al.   MOLECULAR DIVERSITY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Myristicyclins A and B: Antimalarial Procyanidins from Horsfieldia spicata from Papua New Guinea

(2013) Zhenyu Lu et al.   ORGANIC LETTERS

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

(2013) ROB DON et al.   PARASITOLOGY

Glabridin induces oxidative stress mediated apoptosis like cell death of malaria parasite Plasmodium falciparum

(2013) Harveer Singh Cheema et al.   PARASITOLOGY INTERNATIONAL

Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement

(2013) Ebenézer de Mello Cruz et al.   PHYTOCHEMISTRY

Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions

(2013) Matheus Balduíno Goncalves dos Reis et al.   PLoS One

Surprising New Dengue Virus Throws a Spanner in Disease Control Efforts

(2013) D. Normile   SCIENCE

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii

(2012) Abiy Yenesew et al.   ACTA TROPICA

Novel antiviral activity of baicalein against dengue virus

(2012) Keivan Zandi et al.   BMC Complementary and Alternative Medicine

Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives

(2012) Vanessa Silva Gontijo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase

(2012) Edson Roberto da Silva et al.   EXPERIMENTAL PARASITOLOGY

American Trypanosomiasis (Chagas Disease)

(2012) Anis Rassi et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains

(2012) Sabrina Cencig et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor

(2012) Diego Magno Assis et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

(2012) Filipa P. da Cruz et al.   JOURNAL OF INFECTIOUS DISEASES

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

(2012) Chandrakala Pidathala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials

(2012) Yiqun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Cinnamoylated Chloroquine Analogues as Dual-Stage Antimalarial Leads

(2012) Bianca C. Pérez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern

(2012) M. MAROLI et al.   MEDICAL AND VETERINARY ENTOMOLOGY

Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones

(2012) Deepa Ganesh et al.   PARASITOLOGY RESEARCH

Biflavonoids ofDacrydium balansaewith Potent Inhibitory Activity on Dengue 2 NS5 Polymerase

(2012) Paul Coulerie et al.   PLANTA MEDICA

Sodium Stibogluconate (SSG) & Paromomycin Combination Compared to SSG for Visceral Leishmaniasis in East Africa: A Randomised Controlled Trial

(2012) Ahmed Musa et al.   PLoS Neglected Tropical Diseases

Oligomeric procyanidins stimulate innate antiviral immunity in dengue virus infected human PBMCs

(2011) Emily M. Kimmel et al.   ANTIVIRAL RESEARCH

Drug discovery in the next decade: innovation needed ASAP

(2011) Youssef L. Bennani   DRUG DISCOVERY TODAY

In vitro antileishmanial and antitrypanosomal activities of flavanones from Baccharis retusa DC. (Asteraceae)

(2011) Simone dos S. Grecco et al.   EXPERIMENTAL PARASITOLOGY

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal

(2011) Tiago Rodrigues et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products from Garcinia brasiliensis as Leishmania Protease Inhibitors

(2011) Ivan O. Pereira et al.   JOURNAL OF MEDICINAL FOOD

Molecular modeling study on the disassembly of dendrimers designed as potential antichagasic and antileishmanial prodrugs

(2011) Jeanine Giarolla et al.   JOURNAL OF MOLECULAR MODELING

In Vitro and in Vivo Trypanocidal Activity of Flavonoids fromDelphinium staphisagriaagainst Chagas Disease

(2011) Clotilde Marín et al.   JOURNAL OF NATURAL PRODUCTS

Alkylated Flavanones from the Bark ofCryptocarya chartaceaAs Dengue Virus NS5 Polymerase Inhibitors

(2011) Pierre-Marie Allard et al.   JOURNAL OF NATURAL PRODUCTS

Antiviral activity of Distictella elongata (Vahl) Urb. (Bignoniaceae), a potentially useful source of anti-dengue drugs from the state of Minas Gerais, Brazil

(2011) L.R. Simões et al.   LETTERS IN APPLIED MICROBIOLOGY

Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate

(2011) Pradeep R Patil et al.   MALARIA JOURNAL

Reactive Oxygen Species Production and Mitochondrial Dysfunction Contribute to Quercetin Induced Death in Leishmania amazonensis

(2011) Fernanda Fonseca-Silva et al.   PLoS One

Antiviral activity of four types of bioflavonoid against dengue virus type-2

(2011) Keivan Zandi et al.   Virology Journal

The development of quinoloneesters as novel antimalarial agents targeting the Plasmodium falciparum bc1protein complex

(2011) Robin Cowley et al.   MedChemComm

A Research Agenda to Underpin Malaria Eradication

(2011) Pedro L. Alonso et al.   PLOS MEDICINE

Anti-HIV and antiplasmodial activity of original flavonoid derivatives

(2010) Gilles Casano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase

(2010) Shingo Arioka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibitors of the Mitochondrial Electron Transport Chain and de novo Pyrimidine Biosynthesis as Antimalarials: The Present Status

(2010) T. Rodrigues et al.   CURRENT MEDICINAL CHEMISTRY

Two new anti-plasmodial flavonoid glycosides fromDurantarepens

(2010) Fozia Ijaz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L.

(2010) Amal M.M. Nour et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chemometric Studies on Natural Products as Potential Inhibitors of the NADH Oxidase from Trypanosoma cruzi Using the VolSurf Approach

(2010) Luciana Scotti et al.   MOLECULES

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination

(2010) Timothy N.C. Wells et al.   TRENDS IN PARASITOLOGY

Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors

(2009) Renato F. Freitas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Flavanoids and Pterocarpans from the Bark of Erythrina fusca

(2009) Phongsak Innok et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Triclosan inhibit the growth of the late liver-stage ofPlasmodium

(2009) Agam Prasad Singh et al.   IUBMB LIFE

Antileishmaniasis Activity of Flavonoids fromConsolidaoliveriana

(2009) Clotilde Marín et al.   JOURNAL OF NATURAL PRODUCTS

Disposition of Naringenin via Glucuronidation Pathway Is Affected by Compensating Efflux Transporters of Hydrophilic Glucuronides

(2009) Haiyan Xu et al.   MOLECULAR PHARMACEUTICS

Pentavalent Antimonials: New Perspectives for Old Drugs

(2009) Frédéric Frézard et al.   MOLECULES

Screening of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase enzyme inhibitors

(2009) Ana C. Leite et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Molecular targets for flavivirus drug discovery

(2008) Aruna Sampath et al.   ANTIVIRAL RESEARCH

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

(2008) Min Yu et al.   Cell Host & Microbe

Bioactivity of flavonoid compounds from Poncirus trifoliata L. (Family: Rutaceae) against the dengue vector, Aedes aegypti L. (Diptera: Culicidae)

(2008) S. Rajkumar et al.   PARASITOLOGY RESEARCH

Oral Metabolism and Efficacy ofKalanchoe pinnataFlavonoids in a Murine Model of Cutaneous Leishmaniasis

(2008) Michelle Muzitano et al.   PLANTA MEDICA

Genistein-Supplemented Diet Decreases Malaria Liver Infection in Mice and Constitutes a Potential Prophylactic Strategy

(2008) Margarida Cunha-Rodrigues et al.   PLoS One