Multiple Ascending Dose Study With the New Renin Inhibitor VTP-27999

New Renin Inhibitor VTP-27999 Alters Renin Immunoreactivity and Does Not Unfold Prorenin

(2013) Manne Krop et al.   HYPERTENSION

Aliskiren accumulation in the kidney

(2013) Sascha Lange et al.   JOURNAL OF HYPERTENSION

Renin Inhibitors and Cardiovascular and Renal Protection: An Endless Quest?

(2012) Michel Azizi et al.   CARDIOVASCULAR DRUGS AND THERAPY

Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

(2011) Lanqi Jia et al.   ACS Medicinal Chemistry Letters

Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement

(2009) D. J. Campbell et al.   CLINICAL CHEMISTRY

Renal and Hormonal Responses to Direct Renin Inhibition With Aliskiren in Healthy Humans

(2008) Naomi D.L. Fisher et al.   CIRCULATION

Clinical Pharmacokinetics and Pharmacodynamics of Aliskiren

(2008) Sujata Vaidyanathan et al.   CLINICAL PHARMACOKINETICS

Circulating versus tissue renin-angiotensin system: On the origin of (pro)renin

(2008) Manne Krop et al.   CURRENT HYPERTENSION REPORTS

Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats

(2008) David L. Feldman et al.   HYPERTENSION

Newly developed renin and prorenin assays and the clinical evaluation of renin inhibitors

(2008) Maarten ADH Schalekamp et al.   JOURNAL OF HYPERTENSION