Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

(2018) N. T. Moldogazieva et al.   FREE RADICAL RESEARCH

High mobility group box 1 promotes the epithelial-to-mesenchymal transition in prostate cancer PC3 cells via the RAGE/NF-κB signaling pathway

(2018) Jingliang Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells

(2018) Lulu Zhou et al.   Redox Biology

Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging

(2018) Mayelín Domínguez-González et al.   EXPERIMENTAL GERONTOLOGY

New approach for understanding genome variations in KEGG

(2018) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

4-Hydroxynonenal (HNE) modified proteins in metabolic diseases

(2017) José Pedro Castro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diabetes-induced hepatic oxidative stress: a new pathogenic role for glycated albumin

(2017) Jessica Patche et al.   FREE RADICAL BIOLOGY AND MEDICINE

Influence of glyco-oxidation on complexes between fibrin(ogen) and insulin-like growth factor-binding protein-1 in patients with diabetes mellitus type 2

(2017) Nikola Gligorijević et al.   FREE RADICAL RESEARCH

Oxidized lipoprotein lipids and atherosclerosis

(2017) Markku Ahotupa   FREE RADICAL RESEARCH

Comprehensive Profiling of Modulation of Nitric Oxide Levels and Mitochondrial Activity in the Injured Brain: An Experimental Study Based on the Fluid Percussion Injury Model in Rats

(2017) Muammer Üçal et al.   JOURNAL OF NEUROTRAUMA

A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage

(2017) K. Adam Bohnert et al.   NATURE

Neo-Epitopes Generated on Hydroxyl Radical Modified GlycatedIgG Have Role in Immunopathology of Diabetes Type 2

(2017) Sidra Islam et al.   PLoS One

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

(2017) Luisa Quinti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death

(2017) Decha Pinkaew et al.   Nature Communications

The “Metabolic Memory” Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications

(2017) Roberto Testa et al.   Nutrients

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds

(2016) Jessica Delhaye et al.   AGE

Oxidative stress and antioxidants: Distress or eustress ?

(2016) Etsuo Niki   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protein oxidation and peroxidation

(2016) M. J. Davies   BIOCHEMICAL JOURNAL

Determinants of rodent longevity in the chaperone-protein degradation network

(2016) Karl A. Rodriguez et al.   CELL STRESS & CHAPERONES

Mass spectrometry-based proteomics of oxidative stress: Identification of 4-hydroxy-2-nonenal (HNE) adducts of amino acids using lysozyme and bovine serum albumin as model proteins

(2016) Roshanak Aslebagh et al.   ELECTROPHORESIS

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

(2016) V. Martínez-Cisuelo et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Targeting the superoxide/nitric oxide ratio by L-arginine and SOD mimic in diabetic rat skin

(2016) Aleksandra Jankovic et al.   FREE RADICAL RESEARCH

Plasma Proteins Modified by Advanced Glycation End Products (AGEs) Reveal Site-specific Susceptibilities to Glycemic Control in Patients with Type 2 Diabetes

(2016) Uta Greifenhagen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

(2016) S. A. Youssef et al.   VETERINARY PATHOLOGY

Mitochondrial dysfunction and oxidative stress in aging and cancer

(2016) Anna V. Kudryavtseva et al.   Oncotarget

The sirtuins, oxidative stress and aging: an emerging link

(2016) Philip I. Merksamer et al.   Aging-US

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species

(2015) Harrison Pride et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice

(2015) Nicolas Grossin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes

(2015) Alan C. H. Lee et al.   PLoS One

Elastin aging and lipid oxidation products in human aorta

(2015) Kamelija Zarkovic et al.   Redox Biology

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts

(2014) Pauline Larroque-Cardoso et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer

(2014) Raynoo Thanan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunoproteasome in animal models of Duchenne muscular dystrophy

(2014) Chiao-nan Joyce Chen et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity

(2014) Donatella Canistro et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Peroxiredoxins as multifunctional enzymes

(2014) M. G. Sharapov et al.   MOLECULAR BIOLOGY

Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

(2013) S. Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Effect of insulin on the soluble receptor for advanced glycation end products (RAGE)

(2013) J. K. Y. Lam et al.   DIABETIC MEDICINE

Nrf2 signaling is impaired in the aging RPE given an oxidative insult

(2013) Mira M. Sachdeva et al.   EXPERIMENTAL EYE RESEARCH

Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster

(2013) Eleni N. Tsakiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive aldehydes – second messengers of free radicals in diabetes mellitus

(2013) M. Jaganjac et al.   FREE RADICAL RESEARCH

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

(2013) G. Vistoli et al.   FREE RADICAL RESEARCH

Regulation of Protein Function and Signaling by Reversible CysteineS-Nitrosylation

(2013) Neal Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage

(2012) Lorena Arranz et al.   AGE

Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction

(2012) Alba Naudí et al.   AMINO ACIDS

The fairytale of the GSSG/GSH redox potential

(2012) Leopold Flohé   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

High-density lipoprotein impedes glycation of low-density lipoprotein

(2012) Nahla N Younis et al.   Diabetes & Vascular Disease Research

Disruption of Nrf2 Signaling Impairs Angiogenic Capacity of Endothelial Cells: Implications for Microvascular Aging

(2012) M. N. Valcarcel-Ares et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation

(2011) R. V. Sekhar et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease

(2011) Ester Aso et al.   BRAIN PATHOLOGY

Structure−Activity Analysis of Diffusible Lipid Electrophiles Associated with Phospholipid Peroxidation: 4-Hydroxynonenal and 4-Oxononenal Analogues

(2011) Colleen E. McGrath et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease

(2011) Anton Rahmadi et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Oxidative protein damage and the proteasome

(2010) S. Grimm et al.   AMINO ACIDS

Catalase evolved to concentrate H 2 O 2 at its active site

(2010) Laura Domínguez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in Type 2 diabetes

(2010) Xystus H. L. Tam et al.   CLINICAL SCIENCE

Modeling general proteostasis: proteome balance in health and disease

(2010) Daniela M Roth et al.   CURRENT OPINION IN CELL BIOLOGY

Advanced glycation end products as biomarkers and gerontotoxins – A basis to explore methylglyoxal-lowering agents for Alzheimer’s disease?

(2010) Martina Krautwald et al.   EXPERIMENTAL GERONTOLOGY

Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes

(2010) Sho-ichi Yamagishi   EXPERIMENTAL GERONTOLOGY

Pathological aspects of lipid peroxidation

(2010) Anne Negre-Salvayre et al.   FREE RADICAL RESEARCH

Induction ofSirt1by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response

(2010) Patricia S. Pardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Oxygen toxicity: chemistry and biology of reactive oxygen species

(2010) Giuseppe Buonocore et al.   Seminars in Fetal & Neonatal Medicine

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Advanced Glycation End Products Subspecies-Selectively Induce Adhesion Molecule Expression and Cytokine Production in Human Peripheral Blood Mononuclear Cells

(2009) H. K. Takahashi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Lipoxygenases – Structure and reaction mechanism

(2009) Alexandra Andreou et al.   PHYTOCHEMISTRY

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

(2009) V. I. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver

(2008) Kevork Hagopian et al.   BIOGERONTOLOGY

Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species

(2008) Rochelle Buffenstein   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Advanced Glycation Endproducts Induce Photocrosslinking and Oxidation of Bovine Lens Proteins Through Type-I Mechanism

(2008) Denis Fuentealba et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY