Determinants of rodent longevity in the chaperone-protein degradation network

Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species

(2015) Harrison Pride et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

(2015) Niki Chondrogianni et al.   FASEB JOURNAL

Sympatric speciation revealed by genome-wide divergence in the blind mole ratSpalax

(2015) Kexin Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

(2015) Kaitlyn N. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition

(2014) Karl A. Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure of Transmembrane Domain of Lysosome-associated Membrane Protein Type 2a (LAMP-2A) Reveals Key Features for Substrate Specificity in Chaperone-mediated Autophagy

(2014) Ashok K. Rout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strength and Function Response to Clinical Interventions of Older Women Categorized by Weakness and Low Lean Mass Using Classifications From the Foundation for the National Institute of Health Sarcopenia Project

(2014) Maren S. Fragala et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The proteasome and the degradation of oxidized proteins: Part III—Redox regulation of the proteasomal system

(2014) Tobias Jung et al.   Redox Biology

Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels

(2013) Sanne M.M. Hensen et al.   BIOCHIMIE

The long-term effects of a life-prolonging heat treatment on the Drosophila melanogaster transcriptome suggest that heat shock proteins extend lifespan

(2013) P. Sarup et al.   EXPERIMENTAL GERONTOLOGY

Reduction in ATP Levels Triggers Immunoproteasome Activation by the 11S (PA28) Regulator during Early Antiviral Response Mediated by IFNβ in Mouse Pancreatic β-Cells

(2013) Wieke Freudenburg et al.   PLoS One

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages

(2012) Samira Salari et al.   CELL STRESS & CHAPERONES

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

(2012) Anson Pierce et al.   JOURNAL OF NEUROCHEMISTRY

Protein damage, repair and proteolysis

(2012) Niki Chondrogianni et al.   MOLECULAR ASPECTS OF MEDICINE

Stress, adaptation, and speciation in the evolution of the blind mole rat, Spalax, in Israel

(2012) Eviatar Nevo   MOLECULAR PHYLOGENETICS AND EVOLUTION

Altered Composition of Liver Proteasome Assemblies Contributes to Enhanced Proteasome Activity in the Exceptionally Long-Lived Naked Mole-Rat

(2012) Karl A. Rodriguez et al.   PLoS One

Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity

(2011) Yael H. Edrey et al.   AGING CELL

Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys

(2011) Kylie Kavanagh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Higher levels of heat shock proteins in longer-lived mammals and birds

(2011) Kurtis D. Salway et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms

(2011) T. Gidalevitz et al.   Cold Spring Harbor Perspectives in Biology

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

(2011) Undine Kruegel et al.   PLoS Genetics

Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species

(2010) Kurtis D. Salway et al.   AGE

HSPB1, actin filament dynamics, and aging cells

(2010) Bindi M. Doshi et al.   Annals of the New York Academy of Sciences

A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice

(2010) Anson Pierce et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes

(2010) Sven B. Jänen et al.   GLIA

Molecular mechanisms of proteasome plasticity in aging

(2010) Karl A. Rodriguez et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A database of vertebrate longevity records and their relation to other life-history traits

(2009) J. P. DE MAGALHÃES et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave

(2009) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

New insights into the mechanism of heat shock response activation

(2008) I. Shamovsky et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction

(2008) Kalavathi Dasuri et al.   FREE RADICAL RESEARCH

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

(2008) A. D. Steele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA