Reactive aldehydes – second messengers of free radicals in diabetes mellitus

SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic embryopathy

(2012) Hongbo Weng et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Ligand- and Structure-Based Drug Design Strategies and PPARδ/α Selectivity

(2012) Vinícius G. Maltarollo et al.   Chemical Biology & Drug Design

Elevated neutrophil elastase and acrolein-protein adducts are associated with W256 regression

(2012) M. Jaganjac et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer

(2012) Morana Jaganjac et al.   CROATIAN MEDICAL JOURNAL

Prediabetic Nephropathy as an Early Consequence of the High-Calorie/High-Fat Diet: Relation to Oxidative Stress

(2012) Hanna Shevalye et al.   ENDOCRINOLOGY

Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress

(2012) Bhaskar Ponugoti et al.   Experimental Diabetes Research

Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008–present)

(2012) Christina Lamers et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus

(2012) Laia Salvadó et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome

(2012) Kalavathi Dasuri et al.   FREE RADICAL RESEARCH

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

(2012) Emilio P. Mottillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal Muscle Lipid Peroxidation and Insulin Resistance in Humans

(2012) Katherine H. Ingram et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The relationship between oxidative stress and the levels of serum circulating adhesion molecules in patients with hyperglycemia crises

(2012) Xing-ping Shen et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Behavior of 4-Hydroxynonenal in Phospholipid Membranes

(2012) Mario Vazdar et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding

(2012) Fernanda A. H. Batista et al.   PLoS One

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity

(2012) Heidi E. Kocalis et al.   PLoS One

Targeting NADPH oxidases in vascular pharmacology

(2012) Agata Schramm et al.   VASCULAR PHARMACOLOGY

Advanced lipoxidation end-products

(2011) Reinald Pamplona   CHEMICO-BIOLOGICAL INTERACTIONS

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion

(2011) Guy Cohen et al.   DIABETES

PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function

(2011) Sergey Lupachyk et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function

(2011) Peter V. Usatyuk et al.   MICROVASCULAR RESEARCH

Lipid peroxidation of poly-unsaturated fatty acids in normal and obese adipose tissues

(2011) G. Cohen et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Signaling and cytotoxic functions of 4-hydroxyalkenals

(2010) Yael Riahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Two Tales of Antioxidant Enzymes on β Cells and Diabetes

(2010) Xin Gen Lei et al.   ANTIOXIDANTS & REDOX SIGNALING

Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress

(2010) Peter Storz   ANTIOXIDANTS & REDOX SIGNALING

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis

(2010) William H. Hoffman et al.   BRAIN RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Regulation of MafA Expression in Pancreatic  -Cells in db/db Mice With Diabetes

(2010) T.-a. Matsuoka et al.   DIABETES

The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator-Activated Receptor  

(2010) Y. Riahi et al.   DIABETES

Involvement of RAGE, NADPH Oxidase, and Ras/Raf-1 Pathway in Glycated LDL-Induced Expression of Heat Shock Factor-1 and Plasminogen Activator Inhibitor-1 in Vascular Endothelial Cells

(2010) Ganesh V. Sangle et al.   ENDOCRINOLOGY

Pathological aspects of lipid peroxidation

(2010) Anne Negre-Salvayre et al.   FREE RADICAL RESEARCH

Natural and synthetic antioxidants: An updated overview

(2010) Agnieszka Augustyniak et al.   FREE RADICAL RESEARCH

A fish oil-rich diet reduces vascular oxidative stress in apoE–/–mice

(2010) Kelly Casós et al.   FREE RADICAL RESEARCH

The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats

(2010) Giancarlo Aldini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Induction of Apoptosis of β Cells of the Pancreas by Advanced Glycation End-Products, Important Mediators of Chronic Complications of Diabetes Mellitus

(2009) Minsu Lim et al.   Annals of the New York Academy of Sciences

Lipid peroxidation is not a prerequisite for the development of obesity and diabetes in high-fat-fed mice

(2009) Florence M. Sohet et al.   BRITISH JOURNAL OF NUTRITION

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes indb/dbMice

(2009) Jamie S. Harmon et al.   ENDOCRINOLOGY

Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders

(2009) Mark P. Mattson   EXPERIMENTAL GERONTOLOGY

Mitochondrial alterations in aging rat brain: effective role of (−)-epigallo catechin gallate

(2009) Ravichandran Srividhya et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Transient Oxidative Stress Damages Mitochondrial Machinery Inducing Persistent β-Cell Dysfunction

(2009) Ning Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

(2009) Kim Ravnskjaer et al.   JOURNAL OF LIPID RESEARCH

15-Hydroxyeicosatetraenoic Acid Is a Preferential Peroxisome Proliferator-Activated Receptor  /  Agonist

(2009) S. Naruhn et al.   MOLECULAR PHARMACOLOGY

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

(2009) Kay-Dietrich Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Upregulation of Aldose Reductase During Foam Cell Formation as Possible Link Among Diabetes, Hyperlipidemia, and Atherosclerosis

(2008) Christian A. Gleissner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice†

(2008) Sharda P. Singh et al.   BIOCHEMISTRY

FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes

(2008) D. Demozay et al.   DIABETES

Oxidative Stress and Covalent Modification of Protein with Bioactive Aldehydes

(2008) Paul A. Grimsrud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel aspects of the molecular mechanisms controlling insulin secretion

(2008) Lena Eliasson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis

(2008) M. R. Torloni et al.   Obesity Reviews

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

(2007) G. Poli et al.   MEDICINAL RESEARCH REVIEWS

Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist

(2007) Barry G. Shearer et al.   MOLECULAR ENDOCRINOLOGY