A polar filter in DNA polymerases prevents ribonucleotide incorporation

A cancer-associated point mutation disables the steric gate of human PrimPol

(2019) Alberto Díaz-Talavera et al.   Scientific Reports

The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide

(2019) Heike M. Kropp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ribonucleotide discrimination by translesion synthesis DNA polymerases

(2018) Alexandra Vaisman et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Eukaryotic DNA polymerases

(2018) Rinku Jain et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Activity and fidelity of human DNA polymerase α depend on primer structure

(2018) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries

(2018) Irina Randrianjatovo-Gbalou et al.   NUCLEIC ACIDS RESEARCH

Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction

(2018) Jithesh Kottur et al.   NUCLEIC ACIDS RESEARCH

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model

(2017) Chloe F. Moss et al.   NUCLEIC ACIDS RESEARCH

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu

(2017) Andrea F. Moon et al.   NUCLEIC ACIDS RESEARCH

Mutagenic cost of ribonucleotides in bacterial DNA

(2017) Jeremy W. Schroeder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η

(2016) Yan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of thermophilic DNA polymerases for the recognition and amplification of C2ʹ-modified DNA

(2016) Tingjian Chen et al.   Nature Chemistry

Processing ribonucleotides incorporated during eukaryotic DNA replication

(2016) Jessica S. Williams et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography

(2016) Ludovic Sauguet et al.   Nature Communications

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

(2016) Emmanuele Crespan et al.   Nature Communications

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

(2016) O. Rechkoblit et al.   Science Advances

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

(2015) Robert E. Johnson et al.   MOLECULAR CELL

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unique Structural Features in DNA Polymerase IV Enable Efficient Bypass of the N 2 Adduct Induced by the Nitrofurazone Antibiotic

(2015) Jithesh Kottur et al.   STRUCTURE

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ

(2015) Rafael Fernandez-Leiro et al.   eLife

Kinetic Mechanisms Governing Stable Ribonucleotide Incorporation in Individual DNA Polymerase Complexes

(2014) Joseph M. Dahl et al.   BIOCHEMISTRY

An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family

(2014) Stanislaw K. Jozwiakowski et al.   NUCLEIC ACIDS RESEARCH

Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase

(2014) Vineet Gaur et al.   NUCLEIC ACIDS RESEARCH

How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells

(2014) Catherine J. Potenski et al.   NUCLEIC ACIDS RESEARCH

Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation

(2014) Heather Ordonez et al.   NUCLEIC ACIDS RESEARCH

Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass

(2014) Heather Ordonez et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of Yeast DNA Polymerase ε Catalytic Domain

(2014) Rinku Jain et al.   PLoS One

Ribose--An Internal Threat to DNA

(2014) K. W. Caldecott   SCIENCE

Structure and Function of an RNA-Reading Thermostable DNA Polymerase

(2013) Nina Blatter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

(2013) Julie Bianchi et al.   MOLECULAR CELL

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

(2013) Matthew Hogg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli

(2013) Amit Sharma et al.   NUCLEIC ACIDS RESEARCH

Cost of rNTP/dNTP pool imbalance at the replication fork

(2013) N. Y. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Architecture of Yeast DNA Polymerase ζ

(2013) Yacob Gómez-Llorente et al.   Cell Reports

The PAD region in the mycobacterial DinB homologue MsPolIV exhibits positional heterogeneity

(2012) Amit Sharma et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Frequent Incorporation of Ribonucleotides during HIV-1 Reverse Transcription and Their Attenuated Repair in Macrophages

(2012) Edward M. Kennedy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase

(2012) Shuangluo Xia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ

(2012) Rajendrakumar A. Gosavi et al.   NUCLEIC ACIDS RESEARCH

Spacing between core recognition motifs determines relative orientation of AraR monomers on bipartite operators

(2012) Deepti Jain et al.   NUCLEIC ACIDS RESEARCH

Mechanisms Employed by Escherichia coli to Prevent Ribonucleotide Incorporation into Genomic DNA by Pol V

(2012) John P. McDonald et al.   PLoS Genetics

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cloning, expression, purification, crystallization and preliminary crystallographic analysis of MsDpo4: a Y-family DNA polymerase fromMycobacterium smegmatis

(2011) Amit Sharma et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Unlocking the Sugar “Steric Gate” of DNA Polymerases

(2011) Jessica A. Brown et al.   BIOCHEMISTRY

Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases

(2011) Danielle L. Watt et al.   DNA REPAIR

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Kinetic Basis of Sugar Selection by a Y-Family DNA Polymerase fromSulfolobus solfataricusP2

(2010) Shanen M. Sherrer et al.   BIOCHEMISTRY

DNA Polymerase β Ribonucleotide Discrimination

(2010) Nisha A. Cavanaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insight into Translesion Synthesis by DNA Pol II

(2009) Feng Wang et al.   CELL

A Novel Mechanism of Sugar Selection Utilized by a Human X-Family DNA Polymerase

(2009) Jessica A. Brown et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

(2009) Michael K Swan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fingers-Closing and Other Rapid Conformational Changes in DNA Polymerase I (Klenow Fragment) and Their Role in Nucleotide Selectivity†

(2008) Catherine M. Joyce et al.   BIOCHEMISTRY

Structure of PolC reveals unique DNA binding and fidelity determinants

(2008) R. J. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA