Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 91, Issue -, Pages 153-168Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2018.08.015
Keywords
Pluripotent stem cell; Directed differentiation; Kidney development; Kidney organoid; Transdifferentiation; Human nephron progenitor
Categories
Funding
- NHMRC (Australia) [GNT1098654, GNT1100970]
- National Institutes of Health (USA) [DK107344-01]
Ask authors/readers for more resources
Decades of research into the molecular and cellular regulation of kidney morphogenesis in rodent models, particularly the mouse, has provided both an atlas of the mammalian kidney and a roadmap for recreating kidney cell types with potential applications for the treatment of kidney disease. With advances in both our capacity to maintain nephron progenitors in culture, reprogram to kidney cell types and direct the differentiation of human pluripotent stem cells to kidney endpoints, renal regeneration via cellular therapy or tissue engineering may be possible. Human kidney models also have potential for disease modelling and drug screening. Such applications will rely upon the accuracy of the model at the cellular level and the capacity for stem-cell derived kidney tissue to recapitulate both normal and diseased kidney tissue. In this review, we will discuss the available cell sources, how well they model the human kidney and how far we are from application either as models or for tissue engineering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available