Genome mining- and synthetic biology-enabled production of hypermodified peptides

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

(2019) Maximilian J. Helf et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Discovery of a Pederin Family Compound in a Nonsymbiotic Bloom-Forming Cyanobacterium

(2018) Andreja Kust et al.   ACS Chemical Biology

Enhanced Solubilization of Class B Radical S-Adenosylmethionine Methylases by Improved Cobalamin Uptake in Escherichia coli

(2018) Nicholas D. Lanz et al.   BIOCHEMISTRY

Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3

(2018) Martin I. McLaughlin et al.   BIOCHEMISTRY

Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp.

(2018) Yiwen Tao et al.   JOURNAL OF ORGANIC CHEMISTRY

Parallel lives of symbionts and hosts: chemical mutualism in marine animals

(2018) Maho Morita et al.   NATURAL PRODUCT REPORTS

Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis

(2018) Alexander Crits-Christoph et al.   NATURE

Accessing chemical diversity from the uncultivated symbionts of small marine animals

(2018) Thomas E Smith et al.   Nature Chemical Biology

The biomass distribution on Earth

(2018) Yinon M. Bar-On et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B

(2018) Atsushi Hayata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalamin-dependent radical S-adenosyl-l-methionine enzymes in natural product biosynthesis

(2018) Susan C. Wang   NATURAL PRODUCT REPORTS

The biomass and biodiversity of the continental subsurface

(2018) C. Magnabosco et al.   Nature Geoscience

Bacterial Production of a Pederin Analogue by a Free-Living Marine Alphaproteobacterium

(2017) Carmen Schleissner et al.   JOURNAL OF NATURAL PRODUCTS

Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme

(2017) Yuanyou Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Orthogonal D2O-Based Induction System that Provides Insights intod-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases

(2016) Brandon I. Morinaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution

(2016) Sebastian W. Fuchs et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The importance of N-methylations for the stability of the $$\beta ^{6.3}$$ β 6.3 -helical conformation of polytheonamide B

(2016) Annick Renevey et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Natural Product Discovery through Improved Functional Metagenomics in Streptomyces

(2016) Hala A. Iqbal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

(2016) Michael F. Freeman et al.   Nature Chemistry

Reconstructing a hydrogen-driven microbial metabolic network in Opalinus Clay rock

(2016) Alexandre Bagnoud et al.   Nature Communications

Single-cell genomics-based analysis of virus–host interactions in marine surface bacterioplankton

(2015) Jessica M Labonté et al.   ISME Journal

Computational eco-systems biology in Tara Oceans: translating data into knowledge

(2015) S. Sunagawa et al.   Molecular Systems Biology

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Consecutive radicalS-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

(2015) Daniel R. Marous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic opportunists dominate the deep-subsurface biosphere in South Africa

(2015) G. Borgonie et al.   Nature Communications

RadicalS-Adenosyl Methionine Epimerases: Regioselective Introduction of DiverseD-Amino Acid Patterns into Peptide Natural Products

(2014) Brandon I. Morinaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Metagenomic small molecule discovery methods

(2014) Zachary Charlop-Powers et al.   CURRENT OPINION IN MICROBIOLOGY

Mechanistic Diversity of RadicalS-Adenosylmethionine (SAM)-dependent Methylation

(2014) Matthew R. Bauerle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Chemical-biogeographic survey of secondary metabolism in soil

(2014) Z. Charlop-Powers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Encyclopedia of Bacteria and Archaea: Sequencing a Myriad of Type Strains

(2014) Nikos C. Kyrpides et al.   PLOS BIOLOGY

Microsclerodermins from Terrestrial Myxobacteria: An Intriguing Biosynthesis Likely Connected to a Sponge Symbiont

(2013) Thomas Hoffmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses

(2013) A. Kampa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatable Vectors for Environmental Gene Expression in Alphaproteobacteria

(2012) Adrian J. Tett et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel

(2012) Naoki Shinohara et al.   ChemMedChem

Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel

(2012) Hiroaki Itoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

In Vitro Phosphinate Methylation by PhpK fromKitasatospora phosalacinea

(2011) Williard J. Werner et al.   BIOCHEMISTRY

A cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial-insertion into the membrane

(2010) Masayuki Iwamoto et al.   FEBS LETTERS

Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge

(2010) Toshiyuki Hamada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of the large non-ribosomal peptide polytheonamide B

(2010) Masayuki Inoue et al.   Nature Chemistry

Metabolites from symbiotic bacteria

(2008) Jörn Piel   NATURAL PRODUCT REPORTS