Cobalamin-dependent radical S-adenosyl-l-methionine enzymes in natural product biosynthesis

C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-adenosyl-l-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration

(2018) Shusuke Sato et al.   BIOCHEMISTRY

Enhanced Solubilization of Class B Radical S-Adenosylmethionine Methylases by Improved Cobalamin Uptake in Escherichia coli

(2018) Nicholas D. Lanz et al.   BIOCHEMISTRY

Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3

(2018) Martin I. McLaughlin et al.   BIOCHEMISTRY

Stereochemical Course of Methyl Transfer by Cobalamin-Dependent Radical SAM Methyltransferase in Fosfomycin Biosynthesis

(2018) Anna Schweifer et al.   BIOCHEMISTRY

Efficient methylation of C2 in l-tryptophan by the cobalamin-dependent radicalS-adenosylmethionine methylase TsrM requires an unmodified N1 amine

(2017) Anthony J. Blaszczyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme

(2017) Yuanyou Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical S-Adenosyl-l-methionine Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration

(2017) Hak Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis

(2017) Jennifer Bridwell-Rabb et al.   NATURE

Mechanistic insights into class B radical-S-adenosylmethionine methylases: ubiquitous tailoring enzymes in natural product biosynthesis

(2016) Shanshan Zhou et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis

(2016) Aubérie Parent et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectroscopic and Electrochemical Characterization of the Iron–Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase

(2016) Anthony J. Blaszczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

(2016) Michael F. Freeman et al.   Nature Chemistry

An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis

(2016) Jennifer Bridwell-Rabb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of enzymatic C-P bond formation using multiple quantum HCP nuclear magnetic resonance spectroscopy

(2015) Kaifeng Hu et al.   MAGNETIC RESONANCE IN CHEMISTRY

Consecutive radicalS-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

(2015) Daniel R. Marous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction

(2015) Alhosna Benjdia et al.   Nature Communications

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

(2014) Sascha Baumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spectroscopic characterization and mechanistic investigation of P-methyl transfer by a radical SAM enzyme from the marine bacterium Shewanella denitrificans OS217

(2014) Kylie D. Allen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Mechanistic Diversity of RadicalS-Adenosylmethionine (SAM)-dependent Methylation

(2014) Matthew R. Bauerle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis

(2013) Kylie D. Allen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Radical SAM-mediated methylation reactions

(2013) Danica Galonić Fujimori   CURRENT OPINION IN CHEMICAL BIOLOGY

GenK-Catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme

(2013) Hak Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Structure–Function Linkage Database

(2013) Eyal Akiva et al.   NUCLEIC ACIDS RESEARCH

Diversity and abundance of phosphonate biosynthetic genes in nature

(2013) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes

(2012) Stéphane Pierre et al.   Nature Chemical Biology

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Vitro Phosphinate Methylation by PhpK fromKitasatospora phosalacinea

(2011) Williard J. Werner et al.   BIOCHEMISTRY

Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(ii) complex

(2011) Denis S. Salnikov et al.   DALTON TRANSACTIONS

Structural Basis of Regiospecificity of a Mononuclear Iron Enzyme in Antibiotic Fosfomycin Biosynthesis

(2011) Danny Yun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal centers in the anaerobic microbial metabolism of CO and CO2

(2011) Güneş Bender et al.   Metallomics

Identification of a methylase required for 2-methylhopanoid production and implications for the interpretation of sedimentary hopanes

(2010) P. V. Welander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anaerobic functionalization of unactivated C–H bonds

(2009) Squire J Booker   CURRENT OPINION IN CHEMICAL BIOLOGY

Thiostrepton Biosynthesis: Prototype for a New Family of Bacteriocins

(2009) Wendy L. Kelly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insights into the reactivation of cobalamin-dependent methionine synthase

(2009) M. Koutmos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA