Focused ultrasound in Parkinson's disease: A twofold path toward disease modification

α-Synuclein and Glia in Parkinson’s Disease: A Beneficial or a Detrimental Duet for the Endo-Lysosomal System?

(2019) Alice Filippini et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity

(2019) Vignayanandam Ravindernath Muddapu et al.   Frontiers in Neural Circuits

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

(2019) Alberto J. Espay et al.   NEUROLOGY

Emerging therapies in Parkinson disease — repurposed drugs and new approaches

(2019) Ahmad Elkouzi et al.   Nature Reviews Neurology

Prodromal Parkinson's Disease: The Decade Past, the Decade to Come

(2019) Ronald B. Postuma et al.   MOVEMENT DISORDERS

Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?

(2019) Richard J. Price et al.   MOVEMENT DISORDERS

Biomarkers of Parkinson’s disease: 20 years later

(2019) Rezzak Yilmaz et al.   JOURNAL OF NEURAL TRANSMISSION

Focused ultrasound opening of the blood–brain barrier for treatment of Parkinson's disease

(2019) Peter A. LeWitt et al.   MOVEMENT DISORDERS

Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson's disease

(2019) Maria Eleni Karakatsani et al.   JOURNAL OF CONTROLLED RELEASE

Functional lesional neurosurgery for tremor: a systematic review and meta-analysis

(2018) Sebastian R Schreglmann et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease: a pilot study

(2018) Raul Martínez-Fernández et al.   LANCET NEUROLOGY

Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

(2018) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Elephants, Parkinson's Disease, and Proof-of-Concept Clinical Trials

(2018) Jesse M. Cedarbaum   MOVEMENT DISORDERS

Neurological adverse event profile of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor

(2018) Paul S. Fishman et al.   MOVEMENT DISORDERS

Probing the striatal dopamine system for a putative neuroprotective effect of deep brain stimulation in Parkinson's disease

(2018) Gian Pal et al.   MOVEMENT DISORDERS

Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations

(2018) Anthony E. Lang et al.   MOVEMENT DISORDERS

Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease

(2018) Mallory L. Hacker et al.   NEUROLOGY

A meta-analysis of outcomes and complications of magnetic resonance–guided focused ultrasound in the treatment of essential tremor

(2018) Nasser Mohammed et al.   Neurosurgical Focus

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Single-axon tracing of the corticosubthalamic hyperdirect pathway in primates

(2018) Dymka Coudé et al.   Brain Structure & Function

Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound

(2018) Kristiana Xhima et al.   MOVEMENT DISORDERS

Gene therapy for neurological disorders: progress and prospects

(2018) Benjamin E. Deverman et al.   NATURE REVIEWS DRUG DISCOVERY

A Cortical Pathogenic Theory of Parkinson’s Disease

(2018) Guglielmo Foffani et al.   NEURON

State-of-the-art of microbubble-assisted blood-brain barrier disruption

(2018) Kang-Ho Song et al.   Theranostics

History and future challenges of the subthalamic nucleus as surgical target: Review article

(2018) Jorge Guridi et al.   MOVEMENT DISORDERS

BDNF provides many routes toward STN DBS-mediated disease modification

(2018) D. Luke Fischer et al.   MOVEMENT DISORDERS

Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease

(2018) Maria Nguyen et al.   TRENDS IN NEUROSCIENCES

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

(2018) Andreas Weihofen et al.   NEUROBIOLOGY OF DISEASE

Compensatory mechanisms in Parkinson's disease: Circuits adaptations and role in disease modification

(2017) Javier Blesa et al.   EXPERIMENTAL NEUROLOGY

Subthalamotomy for Parkinson’s disease: clinical outcome and topography of lesions

(2017) Rafael Rodriguez-Rojas et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations

(2017) Andrew Sharott et al.   JOURNAL OF NEUROSCIENCE

Amyloid β Plaque Reduction With Antibodies Crossing the Blood-Brain Barrier, Which Was Opened in 3 Sessions of Focused Ultrasound in a Rabbit Model

(2017) Tereza Alecou et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Current applications and limitations of surgical treatments for movement disorders

(2017) Paul Krack et al.   MOVEMENT DISORDERS

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Idiopathic REM sleep behaviour disorder and neurodegeneration — an update

(2017) Birgit Högl et al.   Nature Reviews Neurology

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Effects of α-synuclein on axonal transport

(2017) Laura A. Volpicelli-Daley   NEUROBIOLOGY OF DISEASE

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

(2017) Charissa Poon et al.   NEUROPHARMACOLOGY

Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models

(2017) S. Pablo Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder

(2017) Thomas R Barber et al.   SLEEP

Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate

(2017) Anna Migdalska-Richards et al.   SYNAPSE

Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression

(2017) D. Luke Fischer et al.   Scientific Reports

Safety and Efficacy of Focused Ultrasound Thalamotomy for Patients With Medication-Refractory, Tremor-Dominant Parkinson Disease

(2017) Aaron E. Bond et al.   JAMA Neurology

Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder

(2017) Thomas R Barber et al.   SLEEP

Survival and dementia inGBA-associated Parkinson's disease: The mutation matters

(2016) Roberto Cilia et al.   ANNALS OF NEUROLOGY

The breakup of intravascular microbubbles and its impact on the endothelium

(2016) Wolfgang Wiedemair et al.   Biomechanics and Modeling in Mechanobiology

Deep brain stimulation modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson’s disease

(2016) Ashwini Oswal et al.   BRAIN

Gamma knife radiosurgery in movement disorders: Indications and limitations

(2016) Yoshinori Higuchi et al.   MOVEMENT DISORDERS

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Ultrasound treatment of neurological diseases — current and emerging applications

(2016) Gerhard Leinenga et al.   Nature Reviews Neurology

Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

(2016) K. Del Tredici et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor

(2016) W. Jeffrey Elias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

(2016) Zsofia I. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Behavioral alterations following blood-brain barrier disruption stimulated by focused ultrasound

(2016) Feng-Yi Yang et al.   Oncotarget

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Toshiki Uchihara et al.   ACTA NEUROPATHOLOGICA

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6-OHDA lesioned Parkinsonian rats

(2015) Andrea Ferrigno et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

Microbubbles and Blood–Brain Barrier Opening: A Numerical Study on Acoustic Emissions and Wall Stress Predictions

(2015) Nazanin Hosseinkhah et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Neurological applications of transcranial high intensity focused ultrasound

(2015) Tony R. Wang et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Enhanced Delivery and Bioactivity of the Neurturin Neurotrophic Factor through Focused Ultrasound—Mediated Blood—Brain Barrier Opening in vivo

(2015) Gesthimani Samiotaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulatesl-DOPA-induced rotational behavior in a rodent model of Parkinson's disease

(2015) Marie-Therese Fuzzati-Armentero et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Differential effects of severe vs mild GBA mutations on Parkinson disease

(2015) Z. Gan-Or et al.   NEUROLOGY

Inflammation is genetically implicated in Parkinson’s disease

(2015) N. Dzamko et al.   NEUROSCIENCE

The relation between α-synuclein and microglia in Parkinson’s disease: Recent developments

(2015) V. Sanchez-Guajardo et al.   NEUROSCIENCE

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Blood-Brain Barrier Opening in Behaving Non-Human Primates via Focused Ultrasound with Systemically Administered Microbubbles

(2015) Matthew E. Downs et al.   Scientific Reports

Neuromodulation accompanying focused ultrasound-induced blood-brain barrier opening

(2015) Po-Chun Chu et al.   Scientific Reports

Subthalamic nucleus lesion improves cell survival and functional recovery following dopaminergic cell transplantation in parkinsonian rats

(2014) Karina Kohn Cordeiro et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Subthalamic nucleus-deep brain stimulation for early motor complications in Parkinson's disease-the EARLYSTIM trial: Early is not always better

(2014) Tiago A. Mestre et al.   MOVEMENT DISORDERS

Levodopa therapy for Parkinson's disease: Pharmacokinetics and pharmacodynamics

(2014) Peter A. LeWitt   MOVEMENT DISORDERS

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

(2013) Jessica F. Jordão et al.   EXPERIMENTAL NEUROLOGY

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

(2013) Giulia Ambrosi et al.   JOURNAL OF NEURAL TRANSMISSION

Subthalamic neurostimulation for Parkinson's disease with early fluctuations: balancing the risks and benefits

(2013) Günther Deuschl et al.   LANCET NEUROLOGY

The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

(2013) Rituraj Niranjan   MOLECULAR NEUROBIOLOGY

Quantitative assessment of cerebral glucose metabolic rates after blood–brain barrier disruption induced by focused ultrasound using FDG-MicroPET

(2013) Feng-Yi Yang et al.   NEUROIMAGE

Neurostimulation for Parkinson's Disease with Early Motor Complications

(2013) W.M.M. Schuepbach et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Pilot Study of Focused Ultrasound Thalamotomy for Essential Tremor

(2013) W. Jeffrey Elias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease

(2012) Matthew J Betts et al.   BRITISH JOURNAL OF PHARMACOLOGY

Temporary Disruption of the Blood-Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

(2012) N. McDannold et al.   CANCER RESEARCH

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

The significance of defining preclinical or prodromal Parkinson's disease

(2012) C. Warren Olanow et al.   MOVEMENT DISORDERS

Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model

(2012) Ming-Hong Hsieh et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys

(2011) G. J. Masilamoni et al.   BRAIN

The Role of Caveolin-1 in Blood–Brain Barrier Disruption Induced by Focused Ultrasound Combined with Microbubbles

(2011) Jinmu Deng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

(2011) Timothy J. Collier et al.   NATURE REVIEWS NEUROSCIENCE

Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo

(2011) Fabrice Marquet et al.   PLoS One

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease

(2010) PJ Austin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of zona incerta lesions on striatal neurochemistry and behavioral asymmetry in 6-hydroxydopamine-lesioned rats

(2010) Ruth H. Walker et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss

(2010) A.L. Spieles-Engemann et al.   NEUROBIOLOGY OF DISEASE

Dopaminergic cells in the periaqueductal grey matter of MPTP-treated monkeys and mice; patterns of survival and effect of deep brain stimulation and lesion of the subthalamic nucleus

(2010) Victoria E. Shaw et al.   PARKINSONISM & RELATED DISORDERS

Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

(2010) Jessica F. Jordão et al.   PLoS One

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Effects of subthalamic nucleus lesions and stimulation upon glutamate levels in the dopamine-depleted rat striatum

(2009) Ruth H. Walker et al.   NEUROREPORT

Recent Advances in Blood–Brain Barrier Disruption as a CNS Delivery Strategy

(2008) Marc-André Bellavance et al.   AAPS Journal

Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive Parkinsonism

(2007) Daniel Harnack et al.   EXPERIMENTAL NEUROLOGY