Article
Clinical Neurology
Jiping Li, Shanshan Mei, Xiaofei Jia, Yuqing Zhang
Summary: This study demonstrates that deep brain stimulation can effectively suppress levodopa-induced dyskinesia in Parkinson's disease patients without reducing levodopa dosage. The stimulation sites with good anti-dyskinesia effect are located above the subthalamic nucleus.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Review
Behavioral Sciences
Chun-Hwei Tai
Summary: Understanding the pathophysiological mechanism of Parkinson's disease in the subthalamic nucleus is crucial for effective treatment through deep brain stimulation. STN burst firing is considered an electrophysiological signature of the cortico-basal ganglia circuit in PD patients, and plays a significant role in the motor symptoms of PD as well. This review explores the origins of STN bursts, factors influencing their formation, and the potential for interventions to alleviate PD symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Stefanie T. Jost, Lena Strobel, Alexandra Rizos, Philipp A. Loehrer, Keyoumars Ashkan, Julian Evans, Franz Rosenkranz, Michael T. Barbe, Gereon R. Fink, Jeremy Franklin, Anna Sauerbier, Christopher Nimsky, Afsar Sattari, K. Ray Chaudhuri, Angelo Antonini, Lars Timmermann, Pablo Martinez-Martin, Monty Silverdale, Elke Kalbe, Veerle Visser-Vandewalle, Haidar S. Dafsari
Summary: Previous studies have shown that women with Parkinson's disease (PD) have less access to deep brain stimulation (DBS) compared to men. This study observed and compared a total of 505 patients and found that women with PD were less likely to be referred for DBS, but more likely to be approved for the treatment. The study also found that women and men with PD had different preoperative symptoms and characteristics. However, both genders had similar improvements in clinical outcomes after the surgery.
NPJ PARKINSONS DISEASE
(2022)
Article
Neurosciences
Bowen Chang, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
Summary: This study reported a case of a PD patient who significantly improved symptoms after undergoing bilateral globus pallidus interna combined with subthalamic nucleus variable frequency DBS treatment, exploring a new approach for treating dystonia disorders.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Eileen Gulke, Leon Juarez Paz, Heleen Scholtes, Christian Gerloff, Andrea A. Kuehn, Monika Potter-Nerger
Summary: This study evaluated the feasibility of a semi-automatic algorithm-guided programming approach for beneficial stimulation settings in Parkinson's disease patients. The results showed significant improvement in clinical effectiveness compared to standard care procedures. This method represents an important step towards future closed-loop DBS optimization systems.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Fernando Alonso-Frech, Carla Fernandez-Garcia, Victor Gomez-Mayordomo, Mariana H. G. Monje, Celia Delgado-Suarez, Clara Villanueva-Iza, Maria Jose Catalan-Alonso
Summary: Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease, but it can cause adverse effects. This case study found that stimulation of the subthalamic nucleus (STN) using directional electrodes improved motor symptoms but resulted in uncontrollable laughter. The exact electrode placement and stimulation parameters play a crucial role in symptom improvement and adverse effects.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Francesco Cavallieri, Isabella Campanini, Annalisa Gessani, Carla Budriesi, Valentina Fioravanti, Giulia Di Rauso, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Noemi Guagnano, Elisa Bardi, Maria Giulia Corni, Jessica Rossi, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Giuseppe Vannozzi, Elena Bergamini, Giacomo Pavesi, Sara Meoni, Valerie Fraix, Alessandro Fraternali, Annibale Versari, Mirco Lusuardi, Giuseppe Biagini, Andrea Merlo, Elena Moro, Franco Valzania
Summary: This study assessed the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on gait in advanced Parkinson's Disease (PD) patients. The results showed that in the long-term after surgery, STN-DBS can contribute to gait and postural control improvement when used together with dopamine replacement therapy.
JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Alexandre Boutet, Radhika Madhavan, Gavin J. B. Elias, Suresh E. Joel, Robert Gramer, Manish Ranjan, Vijayashankar Paramanandam, David Xu, Jurgen Germann, Aaron Loh, Suneil K. Kalia, Mojgan Hodaie, Bryan Li, Sreeram Prasad, Ailish Coblentz, Renato P. Munhoz, Jeffrey Ashe, Walter Kucharczyk, Alfonso Fasano, Andres M. Lozano
Summary: This study investigates the use of fMRI to predict optimal stimulation settings for Parkinson's disease patients undergoing DBS, demonstrates the establishment of a machine learning model based on fMRI patterns, and suggests that fMRI brain responses could serve as an objective biomarker for clinical response.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Josefine Waldthaler, Miriam Bopp, Nele Kuehn, Bugrahan Bacara, Merle Keuler, Marko Gjorgjevski, Barbara Carl, Lars Timmermann, Christopher Nimsky, David J. Pedrosa
Summary: This study compared changes in motor symptoms of Parkinson's Disease and the corresponding volume of the electrostatic field achieved by DBS programming using GUIDE XTTM versus standard-of-care clinical programming. The results showed that imaging-guided programming using GUIDE XTTM is as effective as clinical programming in controlling motor symptoms.
Article
Clinical Neurology
Maria Antonietta Volonte, Giacomo Clarizio, Sebastiano Galantucci, Pietro Giuseppe Scamarcia, Rosalinda Cardamone, Lina Raffaella Barzaghi, Monica Falautano, Pietro Mortini, Giancarlo Comi, Massimo Filippi
Summary: This study evaluated the long-term effectiveness of STN-DBS treatment on advanced PD patients over a span of 14 years. Results showed significant improvement in tremor, rigidity, and daily dopaminergic dose, but no lasting effect on axial symptoms and cognitive functions. STN-DBS remains an effective therapy for advanced PD patients, extending the period of acceptable quality of life despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Francesco Bove, Francesco Cavallieri, Anna Castrioto, Sara Meoni, Emmanuelle Schmitt, Amelie Bichon, Eugenie Lhommee, Pierre Pelissier, Andrea Kistner, Eric Chevrier, Eric Seigneuret, Stephan Chabardes, Franco Valzania, Valerie Fraix, Elena Moro
Summary: Research on patients with Parkinson's disease (PD) shows that the side of motor symptom onset does not significantly affect the outcome of bilateral subthalamic nucleus deep brain stimulation (STN-DBS).
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Merida Teran Jimenez, Philippe Salles Gandara, Alberto J. Espay
Article
Clinical Neurology
Luca Marsili, Kevin R. Duque, Nathan Gregor, Elhusseini Abdelghany, Jesus Abanto, Andrew P. Duker, Matthew C. Hagen, Alberto J. Espay, Matteo Bologna
Summary: This study found no significant differences in the features of bradykinesia between patients with synucleinopathies and tauopathies.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Nikolai Gil D. Reyes, Daniel G. Di Luca, Vanda McNiven, Anthony E. Lang
Summary: GNB1 encephalopathy is a rare neuro-developmental syndrome caused by pathogenic variants in the GNB1 gene. It is characterized by global developmental delay and co-occurrence of movement disorders, with dystonia being the most common. Other rare phenomenologies include myoclonus, tics, chorea, ataxia, and oculomotor abnormalities. This case report presents a unique phenotype of GNB1 encephalopathy caused by a de novo mutation in exon 11, with symptoms of dystonia, myoclonus, and vertical supranuclear gaze palsy.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Alonso Zea Vera, Adrienne Bruce, Travis R. Larsh, Zachary Jordan, Norbert Bruggemann, Ana Westenberger, Alberto J. Espay, Donald L. Gilbert, Steve W. Wu
Summary: POLR3A-related disorders exhibit significant phenotypic pleomorphism, including a range of movement disorders such as parkinsonism, dystonia, ataxia, and spasticity. Vertical gaze dysfunction and T2-weighted/FLAIR hyperintensity of the superior cerebellar peduncles and midbrain may be useful signs suggestive of this condition.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Antigony Rigas, Tina Mainka, Tamara Pringsheim, Alexander Muenchau, Irene Malaty, Yulia Worbe, Andrea E. Cavanna, Andrew John Lees, Anthony E. Lang, Davide Martino, Christos Ganos
Summary: This study revealed that the diagnostic distinction between primary and functional tics is often difficult, even for expert clinicians, in the absence of clinical information.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Tiago A. Mestre, Michael P. McDermott, Raquel Lobo, Joaquim J. Ferreira, Anthony E. E. Lang
Summary: This study evaluated the "lessebo effect" in disease modification trials in Parkinson's disease and found that it did not exist in these trials. However, the use of placebo instead of an active comparator was a limitation. Prospective measurement of expectation of benefit could help assess the various impacts of placebo use.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Matteo Bologna, Alberto J. Espay, Alfonso Fasano, Giulia Paparella, Mark Hallett, Alfredo Berardelli
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Anthony E. Lang
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Donald C. Brien, Heidi C. Riek, Rachel Yep, Jeff Huang, Brian Coe, Corson Areshenkoff, David Grimes, Mandar Jog, Anthony Lang, Connie Marras, Mario Masellis, Paula McLaughlin, Alicia Peltsch, Angela Roberts, Brian Tan, Derek Beaton, Wendy Lou, Richard Swartz, Douglas P. Munoz
Summary: A simple and non-invasive test was developed using video-based eye tracking and machine learning, which showed high sensitivity in detecting the stages of Parkinson's Disease and cognitive impairment. The classifier reached a sensitivity of 83% and a specificity of 78%.
PARKINSONISM & RELATED DISORDERS
(2023)
Editorial Material
Clinical Neurology
Alberto J. Espay, Kevin McFarthing
Summary: The process of protein aggregation involves the transformation of soluble peptides into insoluble cross-beta amyloids. In Parkinson's disease, soluble monomeric a-synuclein transforms into the amyloid state known as Lewy pathology. Most disease-modifying projects in the therapeutic pipeline for Parkinson's disease aim to reduce the insoluble a-synuclein fraction, while none aim to increase soluble a-synuclein levels. We propose rebalancing the therapeutic pipeline to include treatments that restore soluble a-synuclein within a normal range.
PARKINSONISM & RELATED DISORDERS
(2023)
Editorial Material
Clinical Neurology
Nikolai Gil D. Reyes, Anthony E. Lang
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Seyedeh Narges Tabatabaee, Sajjad Effat Nejad, Ali Nikkhah, Narges Hashemi, Afagh Alavi, Anthony E. E. Lang, Mohammad Rohani, Maziar Emamikhah
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Ashwani Jha, Alberto J. Espay, Andrew J. Lees
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Daniel G. Di Luca, Carolina Ramirez-Gomez, Jurgen Germann, Brendan Santyr, Alexandre Boutet, Luka Milosevic, Anthony E. Lang, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: This study aimed to evaluate the safety and efficacy of deep brain stimulation on the globus pallidus pars interna and externa in MSA-P patients. The surgery did not result in major complications, but did not provide significant clinical benefit as measured by MDS-UPDRS III.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Vindhya Koneru, Alberto J. Espay, Allan J. Cole, Daniel Weintraub, Kathleen Crist, Maria B. Pascual, William G. Ondo
MOVEMENT DISORDERS
(2023)
