Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion

Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex

(2017) Chan Shan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reactivation of telomerase in cancer

(2016) Semih Can Akincilar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

(2016) Hyun-Jin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of mutantTERTpromoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas

(2016) Yinghui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene

(2016) Muhammad Ramlee et al.   Genes

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Telomerase structure

(2014) Sara Sandin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin

(2014) Ram Krishna Thakur et al.   NUCLEIC ACIDS RESEARCH

Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity

(2014) Vinod Kumar Yadav et al.   NUCLEIC ACIDS RESEARCH

Identification of human TERT elements necessary for telomerase recruitment to telomeres

(2014) Jens C Schmidt et al.   eLife

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Engineered reversal of drug resistance in cancer cells--metastases suppressor factors as change agents

(2013) V. K. Yadav et al.   NUCLEIC ACIDS RESEARCH

Tertiary DNA Structure in the Single-Stranded hTERT Promoter Fragment Unfolds and Refolds by Parallel Pathways via Cooperative or Sequential Events

(2012) Zhongbo Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Checkpoints of Viral Gene Expression in Productive and Latent Infection: the Role of the HDAC/CoREST/LSD1/REST Repressor Complex

(2011) B. Roizman   JOURNAL OF VIROLOGY

A critical evaluation of biochemical activities reported for the nucleoside diphosphate kinase/Nm23/Awd family proteins: opportunities and missteps in understanding their biological functions

(2011) Patricia S. Steeg et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Mechanisms of non-metastatic 2 (NME2)-mediated control of metastasis across tumor types

(2011) Ram Krishna Thakur et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells

(2011) Anirban Kar et al.   NUCLEIC ACIDS RESEARCH

REST: transcriptional and epigenetic regulator

(2011) Angela Bithell   Epigenomics

Telomeres and telomerase in normal and cancer stem cells

(2010) Jerry W. Shay et al.   FEBS LETTERS

In Brief

(2010)   NATURE REVIEWS GENETICS

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands

(2009) SunMi L. Palumbo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Nm23-H1–h-Prune complex in cellular physiology: a ‘tip of the iceberg’ protein network perspective

(2009) Alessia Galasso et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells

(2009) Anjali Verma et al.   NUCLEIC ACIDS RESEARCH

Estrogen receptor beta in breast cancer—Diagnostic and therapeutic implications

(2009) Johan Hartman et al.   STEROIDS

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers

(2008) Satoru Kyo et al.   CANCER SCIENCE

DNA damage response at functional and dysfunctional telomeres

(2008) M. P. Longhese   GENES & DEVELOPMENT

Genome-Wide Computational and Expression Analyses Reveal G-Quadruplex DNA Motifs as Conservedcis-Regulatory Elements in Human and Related Species

(2008) Anjali Verma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

(2008) Ram Krishna Thakur et al.   NUCLEIC ACIDS RESEARCH

Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene

(2008) Qingjun Zhu et al.   PLoS One