Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction

Regulatory Roles of Pectin Oligosaccharides on Immunoglobulin Production in Healthy Mice Mediated by Gut Microbiota

(2019) Shanshan Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Role of dietary amino acid balance in diet restriction-mediated lifespan extension, renoprotection, and muscle weakness in aged mice

(2018) Shohei Yoshida et al.   AGING CELL

Peripherally induced regulatory T cells contribute to the control of autoimmune diabetes in the NOD mouse model

(2018) Cornelia Schuster et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fenugreek galactomannan and citrus pectin improve several parameters associated with glucose metabolism and modulate gut microbiota in mice

(2018) Miriam G. Shtriker et al.   NUTRITION

Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2–1 and Prevents Doxorubicin-Induced Ileitis

(2018) Neha M. Sahasrabudhe et al.   Frontiers in Immunology

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

(2018) Yanhai Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

(2017) Leon Zheng et al.   JOURNAL OF IMMUNOLOGY

Bacterial communities in the small intestine respond differently to those in the caecum and colon in mice fed low- and high-fat diets

(2017) Janet C. Onishi et al.   MICROBIOLOGY-SGM

Low-methoxyl lemon pectin attenuates inflammatory responses and improves intestinal barrier integrity in caerulein-induced experimental acute pancreatitis

(2017) Yajun Sun et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function, and microbiota homeostasis

(2017) Kang Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inulin-Type Fructans Modulates Pancreatic–Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner

(2017) Yue He et al.   Frontiers in Immunology

Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

(2016) Mitesh Dwivedi et al.   AUTOIMMUNITY REVIEWS

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Dietary Non-digestible Polysaccharides Ameliorate Intestinal Epithelial Barrier Dysfunction in IL-10 Knockout Mice

(2016) Honggang Wang et al.   Journal of Crohns & Colitis

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

(2016) Frederico R.C. Costa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of pectin supplementation on the fermentation patterns of different structural carbohydrates in rats

(2016) Lingmin Tian et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary Fiber Intake Regulates Intestinal Microflora and Inhibits Ovalbumin-Induced Allergic Airway Inflammation in a Mouse Model

(2016) Zhiyu Zhang et al.   PLoS One

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

(2015) Jia Sun et al.   IMMUNITY

The role for gut permeability in the pathogenesis of type 1 diabetes - a solid or leaky concept?

(2015) Xia Li et al.   PEDIATRIC DIABETES

NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets

(2015) Changyun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Dose-Dependent Effects of a Soluble Dietary Fibre (Pectin) on Food Intake, Adiposity, Gut Hypertrophy and Gut Satiety Hormone Secretion in Rats

(2015) Clare L. Adam et al.   PLoS One

Mechanisms underlying immune effects of dietary oligosaccharides

(2013) Prescilla V Jeurink et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells

(2013) Y. Zhang et al.   BLOOD

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Regulation of intestinal epithelial permeability by tight junctions

(2012) Takuya Suzuki   CELLULAR AND MOLECULAR LIFE SCIENCES

Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse

(2012) C. H. F. Hansen et al.   DIABETOLOGIA

Is the origin of type 1 diabetes in the gut?

(2012) Outi Vaarala   IMMUNOLOGY AND CELL BIOLOGY

Low-Methoxyl Pectin Stimulates Small Intestinal Mucin Secretion Irrespective of Goblet Cell Proliferation and Is Characterized by Jejunum Muc2 Upregulation in Rats

(2012) Shingo Hino et al.   JOURNAL OF NUTRITION

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Two SNPs inNLRP3gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil

(2010) A. Pontillo et al.   AUTOIMMUNITY

An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF- B pathway in a mouse model of colitis-associated colon cancer

(2010) L. Liu et al.   CARCINOGENESIS

Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat

(2010) J. T. J. Visser et al.   DIABETOLOGIA

Dietary Pectin Regulates the Levels of Inflammatory Cytokines and Immunoglobulins in Interleukin-10 Knockout Mice

(2010) Michael B. Ye et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants

(2010) Christoph Grüber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Butyrate and Type 1 Diabetes Mellitus: Can We Fix the Intestinal Leak?

(2010) Nan Li et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Cytokine regulation of tight junctions

(2008) Christopher T. Capaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The "Perfect Storm" for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

(2008) O. Vaarala et al.   DIABETES