Is the origin of type 1 diabetes in the gut?

Up-regulation of small intestinal interleukin-17 immunity in untreated coeliac disease but not in potential coeliac disease or in type 1 diabetes

(2011) A. I. Lahdenperä et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

(2011) E. Badami et al.   DIABETES

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

Human enterovirus infections in children at increased risk for type 1 diabetes: the Babydiet study

(2011) M.-L. Simonen-Tikka et al.   DIABETOLOGIA

PD-L1 blockade overrides Salmonella typhimurium-mediated diabetes prevention in NOD mice: No role for Tregs

(2011) Stephen A. Newland et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells

(2011) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition of Type 1 Diabetes Correlated to a Lactobacillus johnsonii N6.2-Mediated Th17 Bias

(2011) K. Lau et al.   JOURNAL OF IMMUNOLOGY

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier

(2010) Jurgen Karczewski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes

(2010) M. Tiittanen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammatory Tendencies and Overproduction of IL-17 in the Colon of Young NOD Mice Are Counteracted With Diet Change

(2010) C. Alam et al.   DIABETES

Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes

(2010) S. Oikarinen et al.   DIABETES

Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY)

(2010) L. C. Stene et al.   DIABETES

Human Enterovirus RNA in Monthly Fecal Samples and Islet Autoimmunity in Norwegian Children With High Genetic Risk for Type 1 Diabetes: The MIDIA study

(2010) G. Tapia et al.   DIABETES CARE

Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat

(2010) J. T. J. Visser et al.   DIABETOLOGIA

Intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate the serum antibody responses induced by dietary antigen

(2010) Masato Tsuda et al.   IMMUNOLOGY LETTERS

Toward defining the autoimmune microbiome for type 1 diabetes

(2010) Adriana Giongo et al.   ISME Journal

Th17 Cytokines and the Gut Mucosal Barrier

(2010) Christoph Blaschitz et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes

(2010) A. K. Marwaha et al.   JOURNAL OF IMMUNOLOGY

Evidence for Molecular Mimicry between Human T Cell Epitopes in Rotavirus and Pancreatic Islet Autoantigens

(2010) Margo C. Honeyman et al.   JOURNAL OF IMMUNOLOGY

IL-17 Immunity in Human Type 1 Diabetes

(2010) J. Honkanen et al.   JOURNAL OF IMMUNOLOGY

TGF-  Induces IL-9 Production from Human Th17 Cells

(2010) G. Beriou et al.   JOURNAL OF IMMUNOLOGY

Dietary Intervention in Infancy and Later Signs of Beta-Cell Autoimmunity

(2010) Mikael Knip et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lactobacillus johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats

(2010) Ricardo Valladares et al.   PLoS One

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

(2009) J. A. Emamaullee et al.   DIABETES

Diabetes-Specific HLA-DR-Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody-Negative Patients With Type 1 Diabetes

(2009) M. Mojibian et al.   DIABETES

Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice

(2009) A. S. Lee et al.   DIABETOLOGIA

Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model

(2009) Luiz FW Roesch et al.   ISME Journal

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

(2009) David Bending et al.   JOURNAL OF CLINICAL INVESTIGATION

Breastfeeding stimulates total and cow’s milk-specific salivary IgA in infants

(2009) Laura Piirainen et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Leaking gut in type 1 diabetes

(2008) Outi Vaarala   CURRENT OPINION IN GASTROENTEROLOGY

The "Perfect Storm" for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

(2008) O. Vaarala et al.   DIABETES

Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3

(2008) Karen M. Lammers et al.   GASTROENTEROLOGY

Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis

(2008) K. L. Graham et al.   JOURNAL OF VIROLOGY

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

Enhanced levels of cow’s milk antibodies in infancy in children who develop type 1 diabetes later in childhood

(2008) Kristiina Luopajärvi et al.   PEDIATRIC DIABETES