Astaxanthin Modulation of Signaling Pathways That Regulate Autophagy

Astaxanthin Attenuates Environmental Tobacco Smoke-Induced Cognitive Deficits: A Critical Role of p38 MAPK

(2019) Xia Yang et al.   Marine Drugs

The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats

(2019) Xiaolin Deng et al.   Frontiers in Cellular Neuroscience

Effects of palmitate and astaxanthin on cell viability and proinflammatory characteristics of mesenchymal stem cells

(2019) Hamid Yaghooti et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astaxanthin inhibits hallmarks of cancer by targeting the PI3K/NF-κΒ/STAT3 signalling axis in oral squamous cell carcinoma models

(2019) Jaganathan Kowshik et al.   IUBMB LIFE

Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling

(2019) Juan Chen et al.   CYTOTECHNOLOGY

Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway

(2019) Peng Guan et al.   LIFE SCIENCES

Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells

(2019) Likun Gao et al.   Cell Death & Disease

Astaxanthin ameliorates cerulein-induced acute pancreatitis in mice

(2018) Hui Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Comparison of the effect of non-esterified and esterified astaxanthins on endurance performance in mice

(2018) Wataru Aoi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury

(2018) Sajad Fakhri et al.   BRAIN RESEARCH BULLETIN

Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte

(2018) Jung-Pyo Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astaxanthin, a xanthophyll carotenoid, prevents development of dextran sulphate sodium-induced murine colitis

(2018) Shigeki Sakai et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Astaxanthin enhances erlotinib-induced cytotoxicity by p38 MAPK mediated xeroderma pigmentosum complementation group C (XPC) down-regulation in human lung cancer cells

(2018) Jyh-Cheng Chen et al.   Toxicology Research

Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement of ERK and AKT signalling pathway

(2018) Sajad Fakhri et al.   EUROPEAN JOURNAL OF PAIN

Astaxanthin protects lipopolysaccharide-induced inflammatory response in Channa argus through inhibiting NF-κB and MAPKs signaling pathways

(2018) Mu-Yang Li et al.   FISH & SHELLFISH IMMUNOLOGY

Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress

(2017) Xiaotong Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro

(2017) Rui Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice

(2017) Jingyao Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1

(2017) Yingli He et al.   JOURNAL OF CELL BIOLOGY

The Novel Mechanisms Concerning the Inhibitions of Palmitate-Induced Proinflammatory Factor Releases and Endogenous Cellular Stress with Astaxanthin on MIN6 β-Cells

(2017) et al.   Marine Drugs

Involvement of Akt/GSK3β/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment

(2017) Jingwen Qiao et al.   NEUROSCIENCE LETTERS

Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice

(2017) Shaowei Li et al.   PLoS One

Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis

(2017) Quan Fang et al.   Scientific Reports

Astaxanthin mitigates cobalt cytotoxicity in the MG-63 cells by modulating the oxidative stress

(2017) Dahe Li et al.   BMC Pharmacology & Toxicology

Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells

(2016) Jen-Chung Ko et al.   BIOCHEMICAL PHARMACOLOGY

Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells

(2016) Junqing Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt

(2016) Yaoyao Jia et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations

(2016) Lobna A. Abdelzaher et al.   LIFE SCIENCES

Astaxanthin Inhibits Acetaldehyde-Induced Cytotoxicity in SH-SY5Y Cells by Modulating Akt/CREB and p38MAPK/ERK Signaling Pathways

(2016) Tingting Yan et al.   Marine Drugs

High glucose induces autophagy of MC3T3-E1 cells via ROS-AKT-mTOR axis

(2016) Xiaoju Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway

(2016) CHUN-MEI WANG et al.   Molecular Medicine Reports

Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro

(2015) Jingjing Li et al.   Marine Drugs

Astaxanthin Attenuates Early Acute Kidney Injury Following Severe Burns in Rats by Ameliorating Oxidative Stress and Mitochondrial-Related Apoptosis

(2015) Song-Xue Guo et al.   Marine Drugs

Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice

(2015) Jingjing Li et al.   Marine Drugs

Astaxanthin reduces type 2 diabetic-associated cognitive decline in rats via activation of PI3K/Akt and attenuation of oxidative stress

(2015) XIAOBIN LI et al.   Molecular Medicine Reports

Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway

(2015) X. Wen et al.   NEUROSCIENCE

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis

(2015) Jingjing Li et al.   PLoS One

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes

(2014) Wei-Ping Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astaxanthin Alleviates Early Brain Injury Following Subarachnoid Hemorrhage in Rats: Possible Involvement of Akt/Bad Signaling

(2014) Xiang-Sheng Zhang et al.   Marine Drugs

Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy

(2014) Miao Shen et al.   MEDIATORS OF INFLAMMATION

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer

(2013) K. Kavitha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Astaxanthin reduces hepatic endoplasmic reticulum stress and nuclear factor-κB-mediated inflammation in high fructose and high fat diet-fed mice

(2013) Saravanan Bhuvaneswari et al.   CELL STRESS & CHAPERONES

Impact of Divergent Effects of Astaxanthin on Insulin Signaling in L6 Cells

(2013) Manabu Ishiki et al.   ENDOCRINOLOGY

Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway

(2013) AI CHEN et al.   Molecular Medicine Reports

MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy

(2012) Salome Paillas et al.   Autophagy

Resveratrol protects H9c2 embryonic rat heart derived cells from oxidative stress by inducing autophagy: role of p38 mitogen-activated protein kinase

(2012) Xiao Cui Lv et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy

(2012) E Keil et al.   CELL DEATH AND DIFFERENTIATION

Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer

(2012) Kwang Hwa Jung et al.   HEPATOLOGY

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

(2012) A. Orsi et al.   MOLECULAR BIOLOGY OF THE CELL

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells

(2012) Chen Hu et al.   TOXICOLOGY LETTERS

Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation

(2011) Chuan-Ming Xie et al.   FREE RADICAL BIOLOGY AND MEDICINE

TNFα-Induced Necroptosis and Autophagy via Supression of the p38–NF-κB Survival Pathway in L929 Cells

(2011) Yuan-Chao Ye et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells

(2011) Ting Sun et al.   Journal of Translational Medicine

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance

(2011) M A de la Cruz-Morcillo et al.   ONCOGENE

Selenite-induced apoptosis and autophagy in colon cancer cells

(2011) Věra Králová et al.   TOXICOLOGY IN VITRO

p38 Mitogen-Activated Protein Kinase is Involved in Endoplasmic Reticulum Stress-Induced Cell Death and Autophagy in Human Gingival Fibroblasts

(2010) Do-Sung Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells

(2010) Hong-Quan Wang et al.   BRAIN RESEARCH

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells

(2010) Jeong Hwan Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Astaxanthin Improves Stem Cell Potency via an Increase in the Proliferation of Neural Progenitor Cells

(2010) Jeong-Hwan Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astaxanthine Secured Apoptotic Death of PC12 Cells Induced by β-Amyloid Peptide 25–35: Its Molecular Action Targets

(2010) Chi-Huang Chang et al.   JOURNAL OF MEDICINAL FOOD

Triterpenes FromGanoderma LucidumInduce Autophagy in Colon Cancer Through the Inhibition of p38 Mitogen-Activated Kinase (p38 MAPK)

(2010) Anita Thyagarajan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

(2010) Chew Hooi Wong et al.   PLoS One

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting

(2009) J. M. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death

(2009) Kyung-Jin Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells

(2009) Paola Palozza et al.   CANCER LETTERS

The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras

(2009) Joo-Yun Byun et al.   CARCINOGENESIS

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

(2009) Jemma L Webber et al.   EMBO JOURNAL

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astaxanthin Inhibits H2O2-Mediated Apoptotic Cell Death in Mouse Neural Progenitor Cells via Modulation of P38 and MEK Signaling Pathways

(2009) Jeong-Hwan Kim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

(2009) Hai Wu et al.   MECHANISMS OF DEVELOPMENT

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: Role of Nrf2, p53, p38 and phase-II enzymes

(2009) D.N. Tripathi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae

(2008) Keisuke Obara et al.   GENES TO CELLS

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells

(2008) Yasutaka Ikeda et al.   JOURNAL OF NEUROCHEMISTRY

The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice

(2008) Yu-shin Sou et al.   MOLECULAR BIOLOGY OF THE CELL

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

(2008) D-D Li et al.   ONCOGENE

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Atg1 Kinase Complex Is Involved in the Regulation of Protein Recruitment to Initiate Sequestering Vesicle Formation for Nonspecific Autophagy in Saccharomyces cerevisiae

(2007) Heesun Cheong et al.   MOLECULAR BIOLOGY OF THE CELL