Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells

Autophagy as a target for hematological malignancy therapy

(2016) Zhiwu Dong et al.   BLOOD REVIEWS

Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosisviaactivation of mTOR signalling

(2016) Guanwei Fan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

(2015) A. Pandolfi et al.   BLOOD

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

(2015) H. El Hajj et al.   BLOOD

Bone marrow-derived mesenchymal stem cells enhance autophagyviaPI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury

(2015) Jing Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pharmacologic agents targeting autophagy

(2015) Helin Vakifahmetoglu-Norberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Imaging of Apoptosis: From Micro to Macro

(2015) Wenbin Zeng et al.   Theranostics

Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature

(2014) F. M. Millimouno et al.   Cancer Prevention Research

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting

(2014) J. K. Altman et al.   CLINICAL CANCER RESEARCH

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor

(2014) Huan Zhou et al.   Molecular Cancer

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells

(2013) M. L. Torgersen et al.   BLOOD

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

(2013) Dhruv Kumar et al.   CANCER LETTERS

Autophagy in blood cancers: biological role and therapeutic implications

(2013) A. Nencioni et al.   HAEMATOLOGICA

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1

(2012) J. Fang et al.   BLOOD

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

New Strategies in Acute Myeloid Leukemia: Redefining Prognostic Markers to Guide Therapy

(2012) I. Khan et al.   CLINICAL CANCER RESEARCH

Matrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt Inactivation

(2012) Shenghui Zhang et al.   PLoS One

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Autophagy and cancer therapy

(2011) Paola Maycotte et al.   CANCER BIOLOGY & THERAPY

Frontier of Epilepsy Research - mTOR signaling pathway

(2011) Chang-Hoon Cho   EXPERIMENTAL AND MOLECULAR MEDICINE

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

(2011) A M Martelli et al.   LEUKEMIA

Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML

(2010) B. Z. Carter et al.   BLOOD

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Matrine induces apoptosis of human multiple myeloma cells via activation of the mitochondrial pathway

(2010) Han Yixiang et al.   LEUKEMIA & LYMPHOMA

Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy

(2010) Jun-Qiang Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells

(2009) Ya Chun Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS