The Novel Mechanisms Concerning the Inhibitions of Palmitate-Induced Proinflammatory Factor Releases and Endogenous Cellular Stress with Astaxanthin on MIN6 β-Cells

Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response

(2016) Ernest Sargsyan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway

(2016) Huimin Lu et al.   DIABETOLOGIA

Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets

(2015) J. Barlow et al.   BIOCHEMICAL JOURNAL

Palmitate-Induced Impairments of β-Cell Function Are Linked With Generation of Specific Ceramide Species via Acylation of Sphingosine

(2015) Levon Manukyan et al.   ENDOCRINOLOGY

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

(2015) Sumaira Z Hasnain et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

(2015) Yinhua Ni et al.   Scientific Reports

Ghrelin Augments the Expressions and Secretions of Proinflammatory Adipokines, VEGF120and MCP-1, in Differentiated 3T3-L1 Adipocytes

(2014) Atsuko Kitahara et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Supplementing with Dietary Astaxanthin Combined with Collagen Hydrolysate Improves Facial Elasticity and Decreases Matrix Metalloproteinase-1 and -12 Expression: A Comparative Study with Placebo

(2014) Hyun-Sun Yoon et al.   JOURNAL OF MEDICINAL FOOD

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

(2014) Ranga Ambati et al.   Marine Drugs

Astaxanthin reduces hepatic endoplasmic reticulum stress and nuclear factor-κB-mediated inflammation in high fructose and high fat diet-fed mice

(2013) Saravanan Bhuvaneswari et al.   CELL STRESS & CHAPERONES

GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice

(2013) T. Teodoro-Morrison et al.   DIABETOLOGIA

Impact of Divergent Effects of Astaxanthin on Insulin Signaling in L6 Cells

(2013) Manabu Ishiki et al.   ENDOCRINOLOGY

Endogenous oxidative stress, but not ER stress, induces hypoxia-independent VEGF120release through PI3K-dependent pathways in 3T3-L1 adipocytes

(2013) Kazuto Takahashi et al.   Obesity

Astaxanthin prevents loss of insulin signaling and improves glucose metabolism in liver of insulin resistant mice

(2012) Saravanan Bhuvaneswari et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Endoplasmic reticulum stress and pancreatic β-cell death

(2011) Sonya G. Fonseca et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

An intervention study in obese mice with astaxanthin, a marine carotenoid – effects on insulin signaling and pro-inflammatory cytokines

(2011) Elumalai Arunkumar et al.   Food & Function

Glucolipotoxicity in Pancreatic β-Cells

(2011) Ji-Won Kim et al.   Diabetes & Metabolism Journal

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

(2010) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo

(2010) Yoshimi Nakajima et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages

(2009) Yoshimi Kishimoto et al.   EUROPEAN JOURNAL OF NUTRITION

Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress

(2009) Alexander M. Wolf et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

JNK- and IκB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro

(2008) Kazuto Takahashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells

(2008) Elida Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Matrix Metalloproteinase-3 Enhances the Free Fatty Acids-Induced VEGF Expression in Adipocytes Through Toll-Like Receptor 2

(2008) Toru Kawamura et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification

(2007) Wataru Aoi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS