Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation

Mesenchymal Cells in Colon Cancer

(2017) Vasiliki Koliaraki et al.   GASTROENTEROLOGY

Tumor associated CD70 expression is involved in promoting tumor migration and macrophage infiltration in GBM

(2017) Haitao Ge et al.   INTERNATIONAL JOURNAL OF CANCER

Immunotherapy for the Treatment of Urothelial Carcinoma

(2017) Nicholas M. Donin et al.   JOURNAL OF UROLOGY

Targeted agents and immunotherapies: optimizing outcomes in melanoma

(2017) Jason J. Luke et al.   Nature Reviews Clinical Oncology

Abstract 2320: CD70 immune checkpoint ligand is associated with the epithelial-to-mesenchymal transition in non-small cell lung cancer

(2016) Sandra Ortiz-Cuaran et al.   CANCER RESEARCH

CD70 Expression and Its Correlation with Clinicopathological Variables in Squamous Cell Carcinoma of the Head and Neck

(2016) Astrid De Meulenaere et al.   PATHOBIOLOGY

Determination of a CD4+CD25−FoxP3+ T cells subset in tumor-draining lymph nodes of colorectal cancer secreting IL-2 and IFN-γ

(2016) Morteza Jafarinia et al.   TUMOR BIOLOGY

Fibroblasts, an inconspicuous but essential player in colon cancer development and progression

(2016) Naofumi Mukaida et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Regulatory T cells, especially ICOS+ FOXP3+ regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced survival

(2016) Jian-Fei Tu et al.   Scientific Reports

Can Targeting Stroma Pave the Way to Enhanced Antitumor Immunity and Immunotherapy of Solid Tumors?

(2016) E. Pure et al.   Cancer Immunology Research

Melanoma-expressed CD70 is involved in invasion and metastasis

(2015) Christine Pich et al.   BRITISH JOURNAL OF CANCER

First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70

(2015) Taofeek Kunle Owonikoko et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer

(2015) Changhua Zhuo et al.   IMMUNOLOGIC RESEARCH

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD70: An emerging target in cancer immunotherapy

(2015) J. Jacobs et al.   PHARMACOLOGY & THERAPEUTICS

The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy

(2015) Yanping Xiao et al.   Cancer Discovery

Unlocking the potential of CD70 as a novel immunotherapeutic target for non-small cell lung cancer

(2015) Julie Jacobs et al.   Oncotarget

Immune Checkpoint Modulation in Colorectal Cancer: What’s New and What to Expect

(2015) Julie Jacobs et al.   Journal of Immunology Research

Cancer associated fibroblasts have phenotypic and functional characteristics similar to the fibrocytes that represent a novel MDSC subset

(2015) Gurcan Gunaydin et al.   OncoImmunology

Cancer-Associated Fibroblasts Connect Metastasis-Promoting Communication in Colorectal Cancer

(2015) Joke Tommelein et al.   Frontiers in Oncology

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Epithelial to mesenchymal transition might be induced via CD44 isoform switching in colorectal cancer

(2014) Naoki Mashita et al.   JOURNAL OF SURGICAL ONCOLOGY

Functional subsets of mesenchymal cell types in the tumor microenvironment

(2014) Eliane Cortez et al.   SEMINARS IN CANCER BIOLOGY

Regulation of the anti-tumour immune response by cancer-associated fibroblasts

(2014) James Harper et al.   SEMINARS IN CANCER BIOLOGY

The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints

(2014) Nicolas J. Llosa et al.   Cancer Discovery

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

(2013) Scott C. Jeffrey et al.   BIOCONJUGATE CHEMISTRY

Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature

(2013) M. Herrera et al.   CLINICAL CANCER RESEARCH

ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade

(2013) Karen Silence et al.   mAbs

The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial

(2012) A. Huijbers et al.   ANNALS OF ONCOLOGY

CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth

(2012) C. Claus et al.   CANCER RESEARCH

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

(2012) R. J. deLeeuw et al.   CLINICAL CANCER RESEARCH

Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer

(2012) Yung-Chang Lin et al.   INTERNATIONAL JOURNAL OF CANCER

Comparative Analysis of Dynamic Cell Viability, Migration and Invasion Assessments by Novel Real-Time Technology and Classic Endpoint Assays

(2012) Ridha Limame et al.   PLoS One

Human Colonic Myofibroblasts Promote Expansion of CD4+ CD25high Foxp3+ Regulatory T Cells

(2011) Irina V. Pinchuk et al.   GASTROENTEROLOGY

Microsatellite Instability in Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Expression of standard CD44 in human colorectal carcinoma: Association with prognosis

(2009) Jung Wook Huh et al.   PATHOLOGY INTERNATIONAL