Serotonin transport in the 21st century

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

(2019) Jonathan A. Coleman et al.   NATURE

Conformational dynamics of the human serotonin transporter during substrate and drug binding

(2019) Ingvar R. Möller et al.   Nature Communications

A structural model of the human serotonin transporter in an outward-occluded state

(2019) Eva Hellsberg et al.   PLoS One

A kinetic account for amphetamine-induced monoamine release

(2018) Peter S. Hasenhuetl et al.   JOURNAL OF GENERAL PHYSIOLOGY

A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport

(2018) Daniel S. Terry et al.   Nature Communications

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT

(2018) Yuan-Wei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer

(2017) Suraj Adhikary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter

(2016) Peter S. Hasenhuetl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

Structural Symmetry in Membrane Proteins

(2015) Lucy R. Forrest   Annual Review of Biophysics

Properties of an Inward-Facing State of LeuT: Conformational Stability and Substrate Release

(2015) Julie Grouleff et al.   BIOPHYSICAL JOURNAL

Two Na+Sites Control Conformational Change in a Neurotransmitter Transporter Homolog

(2015) Sotiria Tavoulari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transporter Classification Database (TCDB): recent advances

(2015) Milton H. Saier et al.   NUCLEIC ACIDS RESEARCH

Microseconds Simulations Reveal a New Sodium-binding Site and the Mechanism of Sodium-coupled Substrate Uptake by LeuT

(2014) Elia Zomot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

(2014) Lina Malinauskaite et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expansion of the APC superfamily of secondary carriers

(2014) Ake Vastermark et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Electrophysiological Characterization of Membrane Transport Proteins

(2013) Christof Grewer et al.   Annual Review of Biophysics

A quantitative model of amphetamine action on the 5-HT transporter

(2013) Walter Sandtner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional Defects in the External and Internal Thin Gates of the γ-Aminobutyric Acid (GABA) Transporter GAT-1 Can Compensate Each Other

(2013) Assaf Ben-Yona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

(2013) Aravind Penmatsa et al.   JOURNAL OF PHYSIOLOGY-LONDON

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction

(2013) Gary Rudnick et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT

(2012) Chunfeng Zhao et al.   BIOPHYSICAL JOURNAL

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP

(2012) K. Khafizov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression of neuronal dopamine and serotonin transporters DAT and SERT in megakaryocytes and platelets generated from human MEG-01 megakaryoblasts

(2011) Sarah Hohmann et al.   CELL AND TISSUE RESEARCH

Unifying Concept of Serotonin Transporter-associated Currents

(2011) Klaus Schicker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

(2011) Yongfang Zhao et al.   NATURE

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

(2011) A. S. Kristensen et al.   PHARMACOLOGICAL REVIEWS

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

(2010) Yongfang Zhao et al.   NATURE

Substrate-dependent proton antiport in neurotransmitter:sodium symporters

(2010) Yongfang Zhao et al.   Nature Chemical Biology

Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1

(2010) T. Shimamura et al.   SCIENCE

Molecular basis of transport and regulation in the Na+/betaine symporter BetP

(2009) Susanne Ressl et al.   NATURE

Human Serotonin Transporter Expression During Megakaryocytic Differentiation of MEG-01 Cells

(2009) Gino Giannaccini et al.   NEUROCHEMICAL RESEARCH

The Rocking Bundle: A Mechanism for Ion-Coupled Solute Flux by Symmetrical Transporters

(2009) Lucy R. Forrest et al.   PHYSIOLOGY

An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter

(2008) Julie Kniazeff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Serotonin to the Human Serotonin Transporter. Molecular Modeling and Experimental Validation

(2008) Leyla Celik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site

(2008) Lei Shi et al.   MOLECULAR CELL

Mechanism for alternating access in neurotransmitter transporters

(2008) L. R. Forrest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation

(2008) S. K. Singh et al.   SCIENCE

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

(2008) S. Weyand et al.   SCIENCE

The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport

(2008) S. Faham et al.   SCIENCE