Two Na+Sites Control Conformational Change in a Neurotransmitter Transporter Homolog

Properties of an Inward-Facing State of LeuT: Conformational Stability and Substrate Release

(2015) Julie Grouleff et al.   BIOPHYSICAL JOURNAL

Mechanism of the Association between Na+Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

(2015) Sebastian Stolzenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Regulatory Interactions of the Cytoplasmic Terminal Domains of Serotonin Transporter

(2014) Cristina Fenollar-Ferrer et al.   BIOCHEMISTRY

Microseconds Simulations Reveal a New Sodium-binding Site and the Mechanism of Sodium-coupled Substrate Uptake by LeuT

(2014) Elia Zomot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Second Sodium Site in the Dopamine Transporter Controls Cation Permeation and Is Regulated by Chloride

(2014) Lars Borre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational dynamics of ligand-dependent alternating access in LeuT

(2014) Kelli Kazmier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

(2014) Lina Malinauskaite et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport

(2014) Ines A Ehrnstorfer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1

(2014) K. Kazmier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete Mapping of Substrate Translocation Highlights the Role of LeuT N-terminal Segment in Regulating Transport Cycle

(2014) Mary Hongying Cheng et al.   PLoS Computational Biology

The Two Na+Sites in the Human Serotonin Transporter Play Distinct Roles in the Ion Coupling and Electrogenicity of Transport

(2013) Bruce Felts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How do transporters couple solute movements?

(2013) Gary Rudnick   MOLECULAR MEMBRANE BIOLOGY

Chloride binding site of neurotransmitter sodium symporters

(2013) A. K. Kantcheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT

(2012) Chunfeng Zhao et al.   BIOPHYSICAL JOURNAL

The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

(2012) Simon Bulling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP

(2012) Camilo Perez et al.   NATURE

Experimental conditions can obscure the second high-affinity site in LeuT

(2012) Matthias Quick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of Local Hydration and Hydrogen-Bonding Dynamics in Ion and Solute Release from Ion-Coupled Secondary Transporters

(2011) Chunfeng Zhao et al.   BIOCHEMISTRY

A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport

(2011) L. Keith Henry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRIFFIN: A Versatile Methodology for Optimization of Protein−Lipid Interfaces for Membrane Protein Simulations

(2011) René Staritzbichler et al.   Journal of Chemical Theory and Computation

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

(2011) Yongfang Zhao et al.   NATURE

Unbiased Simulations Reveal the Inward-Facing Conformation of the Human Serotonin Transporter and Na+ Ion Release

(2011) Heidi Koldsø et al.   PLoS Computational Biology

A Study of the Evolution of Inverted-Topology Repeats from LeuT-Fold Transporters Using AlignMe

(2010) Kamil Khafizov et al.   BIOCHEMISTRY

Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue

(2010) Sotiria Tavoulari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Glutamine Residue Conserved in the Neurotransmitter:Sodium:Symporters Is Essential for the Interaction of Chloride with the GABA Transporter GAT-1

(2010) Assaf Ben-Yona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

(2010) Yongfang Zhao et al.   NATURE

Substrate-dependent proton antiport in neurotransmitter:sodium symporters

(2010) Yongfang Zhao et al.   Nature Chemical Biology

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters

(2010) Derek P Claxton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two mechanisms of ion selectivity in protein binding sites

(2010) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1

(2010) T. Shimamura et al.   SCIENCE

α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix†

(2009) Adam J. Trexler et al.   BIOCHEMISTRY

Transmembrane Domain 8 of the γ-Aminobutyric Acid Transporter GAT-1 Lines a Cytoplasmic Accessibility Pathway into Its Binding Pocket

(2009) Assaf Ben-Yona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Characterization of Membrane−Protein Interactions for the Leucine Transporter fromAquifex aeolicusby Molecular Dynamics Calculations†

(2009) Diego A. Pantano et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular basis of transport and regulation in the Na+/betaine symporter BetP

(2009) Susanne Ressl et al.   NATURE

Unlocking the molecular secrets of sodium-coupled transporters

(2009) Harini Krishnamurthy et al.   NATURE

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

(2009) M. Quick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

(2009) P. L. Shaffer et al.   SCIENCE

An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter

(2008) Julie Kniazeff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Ion Selectivity in LeuT: Two Na+ Binding Sites with Two Different Mechanisms

(2008) Sergei Y. Noskov et al.   JOURNAL OF MOLECULAR BIOLOGY

The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site

(2008) Lei Shi et al.   MOLECULAR CELL

Mechanism for alternating access in neurotransmitter transporters

(2008) L. R. Forrest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation

(2008) S. K. Singh et al.   SCIENCE

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

(2008) S. Weyand et al.   SCIENCE

The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport

(2008) S. Faham et al.   SCIENCE

Substrate Binding and Formation of an Occluded State in the Leucine Transporter

(2007) Leyla Celik et al.   BIOPHYSICAL JOURNAL