Microseconds Simulations Reveal a New Sodium-binding Site and the Mechanism of Sodium-coupled Substrate Uptake by LeuT

Coupled Global and Local Changes Direct Substrate Translocation by Neurotransmitter-Sodium Symporter Ortholog LeuT

(2013) Mary Hongying Cheng et al.   BIOPHYSICAL JOURNAL

Global motions exhibited by proteins in micro- to milliseconds simulations concur with anisotropic network model predictions

(2013) M. Gur et al.   JOURNAL OF CHEMICAL PHYSICS

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Chloride binding site of neurotransmitter sodium symporters

(2013) A. K. Kantcheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT

(2012) Chunfeng Zhao et al.   BIOPHYSICAL JOURNAL

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue

(2012) Hui Wang et al.   EMBO REPORTS

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context

(2012) Hui Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Experimental conditions can obscure the second high-affinity site in LeuT

(2012) Matthias Quick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

(2011) Yongfang Zhao et al.   NATURE

Large collective motions regulate the functional properties of glutamate transporter trimers

(2011) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue

(2010) Sotiria Tavoulari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site

(2010) Chayne L. Piscitelli et al.   NATURE

Substrate-dependent proton antiport in neurotransmitter:sodium symporters

(2010) Yongfang Zhao et al.   Nature Chemical Biology

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

(2009) Jacob Andersen et al.   CHEMICAL COMMUNICATIONS

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

(2009) M. Quick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

(2009) P. L. Shaffer et al.   SCIENCE

Sodium-Coupled Neurotransmitter Transporters

(2008) Baruch I. Kanner et al.   CHEMICAL REVIEWS

Glycine Transporter Dimers

(2008) Ingo Bartholomäus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

United-Atom Acyl Chains for CHARMM Phospholipids

(2008) Jérôme Hénin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site

(2008) Lei Shi et al.   MOLECULAR CELL

Functional mutations in mouse norepinephrine transporter reduce sensitivity to cocaine inhibition

(2008) Hua Wei et al.   NEUROPHARMACOLOGY

Mechanism for alternating access in neurotransmitter transporters

(2008) L. R. Forrest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation

(2008) S. K. Singh et al.   SCIENCE

The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport

(2008) S. Faham et al.   SCIENCE