Microtubules at focal adhesions – a double-edged sword

Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration

(2019) Bertille Bance et al.   JOURNAL OF CELL SCIENCE

RAB6 and microtubules restrict protein secretion to focal adhesions

(2019) Lou Fourriere et al.   JOURNAL OF CELL BIOLOGY

A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions

(2019) Nisha Bte Mohd Rafiq et al.   NATURE MATERIALS

Motor–cargo adaptors at the organelle–cytoskeleton interface

(2019) Jessica A Cross et al.   CURRENT OPINION IN CELL BIOLOGY

Integrin diversity brings specificity in mechanotransduction

(2018) Shailaja Seetharaman et al.   BIOLOGY OF THE CELL

Kinesin-dependent transport of keratin filaments: a unified mechanism for intermediate filament transport

(2018) Amélie Robert et al.   FASEB JOURNAL

The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation viaα-TAT1gene expression

(2018) Jaime Fernández-Barrera et al.   JOURNAL OF CELL BIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions

(2018) Stephan A Eisler et al.   eLife

Integrin and microtubule crosstalk in the regulation of cellular processes

(2018) Susan E. LaFlamme et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Invadosomes are coming: new insights into function and disease relevance

(2017) Elyse K. Paterson et al.   FEBS Journal

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

Regulation of microtubule-associated motors drives intermediate filament network polarization

(2017) Cécile Leduc et al.   JOURNAL OF CELL BIOLOGY

Talin – the master of integrin adhesions

(2017) Benjamin Klapholz et al.   JOURNAL OF CELL SCIENCE

Single and collective cell migration: the mechanics of adhesions

(2017) Chiara De Pascalis et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanotransduction at the cell-matrix interface

(2017) K.A. Jansen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics

(2016) Wenxiu Ning et al.   DEVELOPMENTAL CELL

An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells

(2016) Francesca Bartolini et al.   MOLECULAR BIOLOGY OF THE CELL

Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

(2016) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

(2016) Benjamin P Bouchet et al.   eLife

Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration

(2016) Zhuo Gan et al.   Cell Systems

Intermediate filaments and the regulation of focal adhesion

(2015) Rudolf E Leube et al.   CURRENT OPINION IN CELL BIOLOGY

Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promoteC. eleganselongation

(2015) Sophie Quintin et al.   DEVELOPMENT

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration

(2015) Dan Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule nucleation at the centrosome and beyond

(2015) Sabine Petry et al.   NATURE CELL BIOLOGY

Control of microtubule organization and dynamics: two ends in the limelight

(2015) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

(2015) Adam Byron et al.   Nature Communications

Molecular architecture and function of the hemidesmosome

(2014) Gernot Walko et al.   CELL AND TISSUE RESEARCH

Invadopodia, Regulation, and Assembly in Cancer Cell Invasion

(2014) Bechara A. Saykali et al.   CELL COMMUNICATION AND ADHESION

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

(2014) Jie Yan et al.   Cellular and Molecular Bioengineering

Microtubules Regulate Focal Adhesion Dynamics through MAP4K4

(2014) Jiping Yue et al.   DEVELOPMENTAL CELL

Microtubule acetylation regulates dynamics of KIF1C-powered vesicles and contact of microtubule plus ends with podosomes

(2014) Ridhirama Bhuwania et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

(2014) Samantha J. Stehbens et al.   NATURE CELL BIOLOGY

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of invadopodia by the tumor microenvironment

(2014) Christine M Gould et al.   Cell Adhesion & Migration

Microtubules in Cell Migration

(2013) Sandrine Etienne-Manneville   Annual Review of Cell and Developmental Biology

CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor

(2013) Babet van der Vaart et al.   DEVELOPMENTAL CELL

Mechanosensing through focal adhesion-anchored intermediate filaments

(2013) Martin Gregor et al.   FASEB JOURNAL

APC binds intermediate filaments and is required for their reorganization during cell migration

(2013) Yasuhisa Sakamoto et al.   JOURNAL OF CELL BIOLOGY

Amotl2 interacts with LL5 , localizes to podosomes and regulates postsynaptic differentiation in muscle

(2013) T. J. Proszynski et al.   JOURNAL OF CELL SCIENCE

Microtubule Dynamic Instability Controls Podosome Patterning in Osteoclasts through EB1, Cortactin, and Src

(2013) M. Biosse Duplan et al.   MOLECULAR AND CELLULAR BIOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion

(2012) Antonio Castro-Castro et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Amer2 Protein Interacts with EB1 Protein and Adenomatous Polyposis Coli (APC) and Controls Microtubule Stability and Cell Migration

(2012) Astrid S. Pfister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cells

(2012) Laura Andrés-Delgado et al.   JOURNAL OF CELL BIOLOGY

Targeting and transport: How microtubules control focal adhesion dynamics

(2012) Samantha Stehbens et al.   JOURNAL OF CELL BIOLOGY

Actin stress fibers - assembly, dynamics and biological roles

(2012) S. Tojkander et al.   JOURNAL OF CELL SCIENCE

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

(2012) David Meiri et al.   MOLECULAR CELL

The Ability to Induce Microtubule Acetylation Is a General Feature of Formin Proteins

(2012) Susan F. Thurston et al.   PLoS One

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

Dynamic regulation of GEF-H1 localization at microtubules by Par1b/MARK2

(2011) Yuta Yoshimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rab6, Rab8, and MICAL3 Cooperate in Controlling Docking and Fusion of Exocytotic Carriers

(2011) Ilya Grigoriev et al.   CURRENT BIOLOGY

Mechanisms of integrin activation and trafficking

(2011) Coert Margadant et al.   CURRENT OPINION IN CELL BIOLOGY

Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration

(2011) Zhizhan Gu et al.   JOURNAL OF CELL BIOLOGY

Protein 4.1R regulates cell migration and IQGAP1 recruitment to the leading edge

(2011) A. Ruiz-Saenz et al.   JOURNAL OF CELL SCIENCE

Differential Distribution of Posttranslationally Modified Microtubules in Osteoclasts

(2011) Toshitaka Akisaka et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules

(2011) Jeremie Gaillard et al.   MOLECULAR BIOLOGY OF THE CELL

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis

(2010) Stephanie L. Gupton et al.   DEVELOPMENTAL CELL

The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly

(2010) Claire Rooney et al.   EMBO REPORTS

Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5α/β

(2010) Azusa Hotta et al.   JOURNAL OF CELL BIOLOGY

Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity

(2010) Jean-Baptiste Manneville et al.   JOURNAL OF CELL BIOLOGY

The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes

(2010) Susanne Cornfine et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells

(2010) Aya Takesono et al.   PLoS One

ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells

(2010) K. Zaoui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A major mutation of KIF21A associated with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) enhances translocation of Kank1 to the membrane

(2009) Naoto Kakinuma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

From signaling pathways to microtubule dynamics: the key players

(2009) Sandrine Etienne-Manneville   CURRENT OPINION IN CELL BIOLOGY

Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins

(2009) Wei-Ting Chao et al.   FEBS LETTERS

GSK3β phosphorylation modulates CLASP–microtubule association and lamella microtubule attachment

(2009) Praveen Kumar et al.   JOURNAL OF CELL BIOLOGY

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

(2009) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

c-Cbl and Cbl-b Act Redundantly to Protect Osteoclasts from Apoptosis and to Displace HDAC6 from β-Tubulin, Stabilizing Microtubules and Podosomes

(2009) Enkhtsetseg Purev et al.   MOLECULAR BIOLOGY OF THE CELL

Podosomes are present in a postsynaptic apparatus and participate in its maturation

(2009) T. J. Proszynski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACF7 Regulates Cytoskeletal-Focal Adhesion Dynamics and Migration and Has ATPase Activity

(2008) Xiaoyang Wu et al.   CELL

Assembly and biological role of podosomes and invadopodia

(2008) Mario Gimona et al.   CURRENT OPINION IN CELL BIOLOGY

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity

(2008) Francesca Bartolini et al.   JOURNAL OF CELL BIOLOGY

Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites

(2008) A. Efimov et al.   JOURNAL OF CELL SCIENCE

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions

(2008) Stavroula Mili et al.   NATURE

Tracking the ends: a dynamic protein network controls the fate of microtubule tips

(2008) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY