Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development

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Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

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Elongation factor-2 kinase acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts

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Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

(2018) Ralf Weiskirchen et al.   MOLECULAR ASPECTS OF MEDICINE

A bi-stable feedback loop between GDNF, EGR1, and ERα contribute to endocrine resistant breast cancer

(2018) Sachi Horibata et al.   PLoS One

NF-kappaB: Two Sides of the Same Coin

(2018) Bruno Pires et al.   Genes

Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

(2018) Yael Raz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

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Ensembl 2019

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Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of Oxysterols in Human Cancer

(2017) Alzbeta Kloudova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

USP9X regulates centrosome duplication and promotes breast carcinogenesis

(2017) Xin Li et al.   Nature Communications

CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue

(2016) Anna Etzold et al.   Epigenetics

The role of myofibroblasts in wound healing

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Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma

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A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

(2015) Elvin Wagenblast et al.   NATURE

The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in Breast Cancers

(2015) Hyeong-Gon Moon et al.   PLoS One

Understanding fibroblast heterogeneity in the skin

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Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

(2015) Jean Albrengues et al.   Nature Communications

The Molecular Signatures Database Hallmark Gene Set Collection

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RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13

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Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis

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Imagine a world without cancer

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Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils

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Regulation of the anti-tumour immune response by cancer-associated fibroblasts

(2014) James Harper et al.   SEMINARS IN CANCER BIOLOGY

FOXO Transcription Factors: Their Clinical Significance and Regulation

(2014) Yu Wang et al.   Biomed Research International

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell Carcinoma

(2013) Daniela Elena Costea et al.   CANCER RESEARCH

Global profiling of prolactin-modulated transcripts in breast cancer in vivo

(2013) Takahiro Sato et al.   Molecular Cancer

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

‘Cancer associated fibroblasts’ – more than meets the eye

(2013) Shalom Madar et al.   TRENDS IN MOLECULAR MEDICINE

Inferring tumour purity and stromal and immune cell admixture from expression data

(2013) Kosuke Yoshihara et al.   Nature Communications

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The role of promoter hypermethylation in fibroblast activation and fibrogenesis

(2012) Elisabeth M Zeisberg et al.   JOURNAL OF PATHOLOGY

Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis)

(2012) Swati Bhattacharyya et al.   JOURNAL OF PATHOLOGY

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

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Matrix metalloproteinases: protective roles in cancer

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OTX1 expression in breast cancer is regulated by p53

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Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion

(2010) K. D. Grugan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

The Transcription of FOXO Genes Is Stimulated by FOXO3 and Repressed by Growth Factors

(2009) Ahmed Essaghir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comprehensive comparison of random forests and support vector machines for microarray-based cancer classification

(2008) Alexander Statnikov et al.   BMC BIOINFORMATICS

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front

(2008) Olivier Wever et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Human Protein Atlas-a tool for pathology

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