CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue

Twist1 Is a Key Regulator of Cancer-Associated Fibroblasts

(2014) K.-W. Lee et al.   CANCER RESEARCH

MLH1constitutional and somatic methylation in patients with MLH1 negative tumors fulfilling the revised Bethesda criteria

(2014) Francesca Crucianelli et al.   Epigenetics

Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness

(2014) X Gong et al.   ONCOGENE

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

(2014) Kendra S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

TGF-  Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment

(2013) T.-L. Yeung et al.   CANCER RESEARCH

Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism

(2013) Rosa Sanchez-Alvarez et al.   CELL CYCLE

Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesis

(2013) L.N. Xu et al.   GENETICS AND MOLECULAR RESEARCH

Cancer-Associated Fibroblasts Promote Proliferation of Endometrial Cancer Cells

(2013) Kavita S. Subramaniam et al.   PLoS One

The Wnt/β-Catenin Pathway Regulates the Expression of the miR-302 Cluster in Mouse ESCs and P19 Cells

(2013) Christien Bräutigam et al.   PLoS One

BRCA1 and p53 regulate critical prostate cancer pathways

(2013) P De Luca et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours

(2013) Roy Milner et al.   VIRCHOWS ARCHIV

Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production

(2012) Ahmed F. Salem et al.   CELL CYCLE

BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion

(2012) Adam Pickard et al.   EMBO JOURNAL

Monozygotic twins discordant for constitutiveBRCA1promoter methylation, childhood cancer and secondary cancer

(2012) Danuta Galetzka et al.   Epigenetics

BRCA1epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer

(2012) Olafur A. Stefansson et al.   Epigenetics

Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer

(2012) T. Hansmann et al.   HUMAN MOLECULAR GENETICS

Primer3—new capabilities and interfaces

(2012) Andreas Untergasser et al.   NUCLEIC ACIDS RESEARCH

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors

(2010) Teresa Tapia et al.   Epigenetics

DNA hypomethylation in cancer: Epigenetic scars of a neoplastic journey

(2010) Charles De Smet et al.   Epigenetics

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

PTCH1+/− Dermal Fibroblasts Isolated from Healthy Skin of Gorlin Syndrome Patients Exhibit Features of Carcinoma Associated Fibroblasts

(2009) Alexandre Valin et al.   PLoS One