Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau

An acetylation mimicking mutation, K274Q, in tau imparts neurotoxicity by enhancing tau aggregation and inhibiting tubulin polymerization

(2019) Jitendra S. Rane et al.   BIOCHEMICAL JOURNAL

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model

(2018) Sheng-Jun Fan et al.   Cell Death & Disease

Highly fluorescent and HDAC6 selective scriptaid analogues

(2018) Cassandra L. Fleming et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Scriptaid cause histone deacetylase inhibition and cell cycle arrest in HeLa cancer cells: A study on structural and functional aspects

(2017) M. Janaki Ramaiah et al.   GENE

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

(2017) Yari Carlomagno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory

(2017) Claude-Henry Volmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

(2017) Jui-Heng Tseng et al.   Cell Reports

Evidence that Non-Fibrillar Tau Causes Pathology Linked to Neurodegeneration and Behavioral Impairments

(2017) Kurt R. Brunden et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

(2017) Yitshak I. Francis et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

(2017) Hanna Trzeciakiewicz et al.   Scientific Reports

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers

(2016) David R. Croucher et al.   Science Signaling

Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers

(2016) David R. Croucher et al.   Science Signaling

Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors

(2015) Sungsu Lim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease

(2015) Xi Lu et al.   Frontiers in Cellular Neuroscience

Identification of disulfide cross-linked tau dimer responsible for tau propagation

(2015) Dohee Kim et al.   Scientific Reports

HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes

(2014) Monika Noack et al.   GLIA

Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

(2014) Maj-Linda Selenica et al.   Alzheimers Research & Therapy

Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?

(2014) Sanaz Bahari-Javan et al.   Frontiers in Neuroscience

Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies

(2013) David J. Irwin et al.   AMERICAN JOURNAL OF PATHOLOGY

Bimolecular Fluorescence Complementation; Lighting-Up Tau-Tau Interaction in Living Cells

(2013) HyeJin Tak et al.   PLoS One

Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease

(2012) Michael P. Walker et al.   AGE

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes

(2012) Yingxiu Li et al.   FEBS Journal

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways

(2011) Jiang-Ping Hu et al.   BRAIN RESEARCH BULLETIN

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates

(2010) Ya-Li Yao et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

(2008) Alan P. Kozikowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE