Nickel Carcinogenesis Mechanism: DNA Damage

Association of BER and NER pathway polymorphism haplotypes and micronucleus frequencies with global DNA methylation in benzene-exposed workers of China

(2019) Guang-hui Zhang et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Comparative mouse lung injury by nickel nanoparticles with differential surface modification

(2019) Yiqun Mo et al.   JOURNAL OF NANOBIOTECHNOLOGY

Base excision repair regulates PD-L1 expression in cancer cells

(2019) Tiara Bunga Mayang Permata et al.   ONCOGENE

Dietary Intake of Cadmium, Chromium, Copper, Nickel, and Lead through the Consumption of Meat, Liver, and Kidney and Assessment of Human Health Risk in Birjand, Southeast of Iran

(2019) Tayebeh Zeinali et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Nucleotide Excision Repair and Transcription‐Associated Genome Instability

(2019) Zivkos Apostolou et al.   BIOESSAYS

Cu(II) and Ni(II) Complexes with New Tridentate NNS Thiosemicarbazones: Synthesis, Characterisation, DNA Interaction, and Antibacterial Activity

(2019) Dorian Polo-Cerón   BIOINORGANIC CHEMISTRY AND APPLICATIONS

A molecular mechanism of nickel (II): reduction of nucleotide excision repair activity by structural and functional disruption of p53

(2018) Yeo Jin Kim et al.   CARCINOGENESIS

Consequences of oxidative damage and mitochondrial dysfunction on the fatty acid profile of muscle of Indian Major Carps considering metal toxicity

(2018) Debjit Das et al.   CHEMOSPHERE

In vitro assessment of antimicrobial and genotoxic effect of metallosurfactant based nickel hydroxide nanoparticles against Escherichia coli and its genomic DNA

(2018) Varsha Dogra et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Chemically-Induced DNA Damage, Mutagenesis, and Cancer

(2018) Ashis Basu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA Damage, Mutagenesis and Cancer

(2018) Ashis Basu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA Injury and Repair Systems

(2018) Guillermo Sáez   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monogenic Diseases of DNA Repair

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Calcium-dependent cyto- and genotoxicity of nickel metal and nickel oxide nanoparticles in human lung cells

(2018) Sebastiano Di Bucchianico et al.   Particle and Fibre Toxicology

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ROS generation and MAPKs activation contribute to the Ni-induced testosterone synthesis disturbance in rat Leydig cells

(2018) Aijie Han et al.   TOXICOLOGY LETTERS

DNA Damage Response in Prostate Cancer

(2018) Matthew J. Schiewer et al.   Cold Spring Harbor Perspectives in Medicine

Toxic effects of nickel oxide (NiO) nanoparticles on the freshwater alga Pseudokirchneriella subcapitata

(2018) Cátia A. Sousa et al.   AQUATIC TOXICOLOGY

Nickel Oxide (NiO) Nanoparticles Induce Loss of Cell Viability in Yeast Mediated by Oxidative Stress

(2018) Cátia A. Sousa et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pro- and antioxidant activity of chromium(III), iron(III), molybdenum(III) or nickel(II) and their mixtures

(2018) Sylwia Terpilowska et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Nickel; whether toxic or essential for plants and environment - A review

(2018) Babar Shahzad et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Mechanisms underlying nickel nanoparticle induced reproductive toxicity and chemo-protective effects of vitamin C in male rats

(2018) Lu Kong et al.   CHEMOSPHERE

Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ-H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines

(2017) Emma Åkerlund et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Mechanisms of DNA damage, repair, and mutagenesis

(2017) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Nickel accumulation and its effect on growth, physiological and biochemical parameters in millets and oats

(2017) Vibha Gupta et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Nickel sulfate induced apoptosis via activating ROS-dependent mitochondria and endoplasmic reticulum stress pathways in rat Leydig cells

(2017) Lingyue Zou et al.   ENVIRONMENTAL TOXICOLOGY

DNA damage and repair, oxidative stress and metabolism biomarker responses in lungs of rats exposed to ambient atmospheric 1-nitropyrene

(2017) Ruijin Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Rare occupational cause of nasal septum perforation: Nickel exposure

(2017) Ertugrul Bolek et al.   International Journal of Occupational Medicine and Environmental Health

In vitro genotoxicity of airborne Ni-NP in air-liquid interface

(2017) Siiri Latvala et al.   JOURNAL OF APPLIED TOXICOLOGY

Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC–MS/MS

(2017) Danni Wu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Cobalt and nickel impair DNA metabolism by the oxidative stress independent pathway

(2017) Vineet Kumar et al.   Metallomics

Genotoxicity study of nickel oxide nanoparticles in female Wistar rats after acute oral exposure

(2017) Naresh Dumala et al.   MUTAGENESIS

Mismatch repair prefers exons

(2017) Dashiell J Massey et al.   NATURE GENETICS

Nickel oxide nanoparticles are highly toxic to SH-SY5Y neuronal cells

(2017) Mahmoud Abudayyak et al.   NEUROCHEMISTRY INTERNATIONAL

Monogenic Diseases of DNA Repair

(2017) Guido Keijzers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response

(2016) Hongrui Guo et al.   Aging-US

Nickel impact on human health: An intrinsic disorder perspective

(2016) Barbara Zambelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Nickel Oxide Nanoparticles Induce Oxidative DNA Damage and Apoptosis in Kidney Cell Line (NRK-52E)

(2016) Mahmoud Abudayyak et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

XPA: A key scaffold for human nucleotide excision repair

(2016) Norie Sugitani et al.   DNA REPAIR

DNA mismatch repair and the DNA damage response

(2016) Zhongdao Li et al.   DNA REPAIR

Mechanisms involved in reproductive toxicity caused by nickel nanoparticle in female rats

(2016) Lu Kong et al.   ENVIRONMENTAL TOXICOLOGY

Nickel(II)-induced nasal epithelial toxicity and oxidative mitochondrial damage

(2016) Yoon-Jin Lee et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes

(2016) Riccardo Bonsignore et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

In vitro and in vivo evaluation of the toxicities induced by metallic nickel nano and fine particles

(2016) Ruth Magaye et al.   JOURNAL OF MOLECULAR HISTOLOGY

Metal binding mediated conformational change of XPA protein:a potential cytotoxic mechanism of nickel in the nucleotide excision repair

(2016) Jianping Hu et al.   JOURNAL OF MOLECULAR MODELING

Exploiting DNA repair defects for novel cancer therapies

(2016) Dik C. van Gent et al.   MOLECULAR BIOLOGY OF THE CELL

Drugging DNA repair

(2016) Stephen P. Jackson et al.   SCIENCE

Nickel-Refining Fumes Induced DNA Damage and Apoptosis of NIH/3T3 Cells via Oxidative Stress

(2016) Yue Wang et al.   International Journal of Environmental Research and Public Health

Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl2)-induced pulmonary toxicity in broiler chickens

(2016) Jie Deng et al.   Toxicology Research

Heavy Metal Exposure Influences Double Strand Break DNA Repair Outcomes

(2016) Maria E. Morales et al.   PLoS One

Nickel Release, ROS Generation and Toxicity of Ni and NiO Micro- and Nanoparticles

(2016) Siiri Latvala et al.   PLoS One

Eukaryotic Mismatch Repair in Relation to DNA Replication

(2015) Thomas A. Kunkel et al.   Annual Review of Genetics

Nickel Chloride (NiCl2) Induces Histopathological Lesions via Oxidative Damage in the Broiler’s Bursa of Fabricius

(2015) Shuang Yin et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Comparative cytotoxic response of nickel ferrite nanoparticles in human liver HepG2 and breast MFC-7 cancer cells

(2015) Maqusood Ahamed et al.   CHEMOSPHERE

Estimation of Aluminum, Arsenic, Lead and Nickel Status in the Samples of Different Cigarettes and their Effect on Human Health of Irish Smoker Hypertensive Consumers

(2015) Hassan Afridi et al.   Clinical Laboratory

ROS-Mediated DNA Methylation Pattern Alterations in Carcinogenesis

(2015) Qihan Wu et al.   CURRENT DRUG TARGETS

Nucleotide excision repair in humans

(2015) Graciela Spivak   DNA REPAIR

Dietary NiCl2 causes G2/M cell cycle arrest in the broiler’s kidney

(2015) Hongrui Guo et al.   Oncotarget

Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury

(2015) Weiwei Lin et al.   Scientific Reports

Could humic acid relieve the biochemical toxicities and DNA damage caused by nickel and deltamethrin in earthworms (Eisenia foetida)?

(2015) Chen-Chao Shen et al.   Environmental Science-Processes & Impacts

Dual Electrochemical and Physiological Apoptosis Assay Detection of in Vivo Generated Nickel Chloride Induced DNA Damage in Caenorhabditis elegans

(2014) Ian M. Huffnagle et al.   ANALYTICAL CHEMISTRY

NiCl2-Down-Regulated Antioxidant Enzyme mRNA Expression Causes Oxidative Damage in the Broiler’s Kidney

(2014) Hongrui Guo et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Inhibitive Effects of Nickel Chloride (NiCl2) on Thymocytes

(2014) Kun Tang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Targeting DNA damage response in cancer therapy

(2014) Noriko Hosoya et al.   CANCER SCIENCE

Quantification of metal ion induced DNA damage with single cell array based assay

(2013) Yong Qiao et al.   ANALYST

Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair

(2013) Timothy L. Scott et al.   ANTIOXIDANTS & REDOX SIGNALING

Nickel-dependent metalloenzymes

(2013) Jodi L. Boer et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reactive Oxygen Species-Mediated DNA Damage and Apoptosis in Human Skin Epidermal Cells After Exposure to Nickel Nanoparticles

(2013) Saud Alarifi et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2)

(2013) Maqusood Ahamed et al.   CHEMOSPHERE

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

DNA damage and oxidative stress in human B lymphoblastoid cells after combined exposure to hexavalent chromium and nickel compounds

(2013) Jianlin Lou et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers

(2013) Bangyuan Wu et al.   FOOD AND CHEMICAL TOXICOLOGY

Sesamin Protects Mouse Liver against Nickel-Induced Oxidative DNA Damage and Apoptosis by the PI3K-Akt Pathway

(2013) Chan-Min Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Associations of neonatal lead, cadmium, chromium and nickel co-exposure with DNA oxidative damage in an electronic waste recycling town

(2013) Wenqing Ni et al.   SCIENCE OF THE TOTAL ENVIRONMENT

DNA Repair by Reversal of DNA Damage

(2013) C. Yi et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers

(2013) Bangyuan Wu et al.   International Journal of Environmental Research and Public Health

The Association between Splenocyte Apoptosis and Alterations of Bax, Bcl-2 and Caspase-3 mRNA Expression, and Oxidative Stress Induced by Dietary Nickel Chloride in Broilers

(2013) Jianying Huang et al.   International Journal of Environmental Research and Public Health

DNA Damage Repair and Bacterial Pathogens

(2013) Darja Žgur-Bertok   PLoS Pathogens

Gene Expression Profiles in Peripheral Blood Mononuclear Cells of Chinese Nickel Refinery Workers with High Exposures to Nickel and Control Subjects

(2012) A. Arita et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy

(2012) Zhen Zhao et al.   DEVELOPMENTAL CELL

Recent progress in studies of metallic nickel and nickel-based nanoparticles’ genotoxicity and carcinogenicity

(2012) Ruth Magaye et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Inducible SOS Response System of DNA Repair and Mutagenesis in Escherichia coli

(2012) Celina Janion   International Journal of Biological Sciences

Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium

(2012) Yana Chervona et al.   Metallomics

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Molecular and genomic approach for understanding the gene-environment interaction between Nrf2 deficiency and carcinogenic nickel-induced DNA damage

(2012) HYE LIM KIM et al.   ONCOLOGY REPORTS

Acute oral toxicity of nickel compounds

(2012) Rayetta G. Henderson et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A filter microplate assay for quantitative analysis of DNA binding proteins using fluorescent DNA

(2011) William C. Yang et al.   ANALYTICAL BIOCHEMISTRY

Comprehensive pathway-based interrogation of genetic variations in the nucleotide excision DNA repair pathway and risk of bladder cancer

(2011) Jinliang Xing et al.   CANCER

Regulation of endonuclease activity in human nucleotide excision repair

(2011) Adebanke F. Fagbemi et al.   DNA REPAIR

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas

(2011) Jörg Felsberg et al.   INTERNATIONAL JOURNAL OF CANCER

Ex vivo study for the assessment of behavioral factor and gene polymorphisms in individual susceptibility to oxidative DNA damage metals-induced

(2011) Angela Di Pietro et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Nickel exposure induces oxidative damage to mitochondrial DNA in Neuro2a cells: the neuroprotective roles of melatonin

(2011) Shang-Cheng Xu et al.   JOURNAL OF PINEAL RESEARCH

Factors Influencing the DNA Nuclease Activity of Iron, Cobalt, Nickel, and Copper Chelates

(2011) Jeff C. Joyner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling

(2011) Zengguang Xu et al.   TOXICOLOGY

Co-exposure to nickel and cobalt chloride enhances cytotoxicity and oxidative stress in human lung epithelial cells

(2011) Eshan Patel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1

(2010) Sarah A. Martin et al.   CANCER CELL

Reactive Oxygen Species-Activated Akt/ASK1/p38 Signaling Pathway in Nickel Compound-Induced Apoptosis in BEAS 2B Cells

(2010) Jingju Pan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Therapeutic Targeting of the DNA Mismatch Repair Pathway

(2010) S. A. Martin et al.   CLINICAL CANCER RESEARCH

A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V

(2010) Meghna Patel et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

(2010) Daniel J. Sargent et al.   JOURNAL OF CLINICAL ONCOLOGY

Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten–nickel–cobalt alloys in vitro

(2010) R.M. Harris et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

(2010) Christoph Loenarz et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Role of Oxidative Stress in Carcinogenesis Induced by Metals and Xenobiotics

(2010) Frank Henkler et al.   Cancers

The DNA-damage response: new molecular insights and new approaches to cancer therapy

(2009) Stephen P. Jackson   BIOCHEMICAL SOCIETY TRANSACTIONS

Coordination of dual incision and repair synthesis in human nucleotide excision repair

(2009) Lidija Staresincic et al.   EMBO JOURNAL

DNA Mismatch Repair Deficiency in Endometrial Carcinoma

(2009) Yevgeniy Karamurzin et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Nickel Ions Inhibit Histone Demethylase JMJD1A and DNA Repair Enzyme ABH2 by Replacing the Ferrous Iron in the Catalytic Centers

(2009) Haobin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

(2008) Detmar Beyersmann et al.   ARCHIVES OF TOXICOLOGY

Epigenetic silencing of O6 -methylguanine DNA methyltransferase gene in NiS-transformed cells

(2008) Weidong Ji et al.   CARCINOGENESIS

Homologous recombination in DNA repair and DNA damage tolerance

(2008) Xuan Li et al.   CELL RESEARCH

Chronic nickel-induced DNA damage and cell death: The protection role of ascorbic acid

(2008) Jie Jia et al.   ENVIRONMENTAL TOXICOLOGY

DNA-damage induction by eight metal compounds in TK6 human lymphoblastoid cells: Results obtained with the alkaline Comet assay

(2008) Emma Guillamet et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

In situ evaluation of heavy metal–DNA interactions using an electrochemical DNA biosensor

(2007) S.C.B. Oliveira et al.   BIOELECTROCHEMISTRY

Genetic and Epigenetic Mechanisms in Metal Carcinogenesis and Cocarcinogenesis: Nickel, Arsenic, and Chromium

(2007) Konstantin Salnikow et al.   CHEMICAL RESEARCH IN TOXICOLOGY