Nucleotide Excision Repair and Transcription‐Associated Genome Instability

Programmed DNA Breaks Activate the Germline Genome in Caenorhabditis elegans

(2018) Matthew M. Wong et al.   DEVELOPMENTAL CELL

Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair

(2018) Wei Wang et al.   DNA REPAIR

Regulation of DNA demethylation by the XPC DNA repair complex in somatic and pluripotent stem cells

(2017) Jaclyn J. Ho et al.   GENES & DEVELOPMENT

ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes

(2017) Takayasu Mori et al.   HUMAN MUTATION

DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes

(2017) Mithu Guha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression

(2017) Sergey Alekseev et al.   MOLECULAR CELL

ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes

(2017) Georgia Chatzinikolaou et al.   NATURE CELL BIOLOGY

CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair

(2017) Fengchao Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair

(2017) Khalid Hilmi et al.   Science Advances

Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond

(2016) Emmanuel Compe et al.   Annual Review of Biochemistry

Transcription as a Threat to Genome Integrity

(2016) Hélène Gaillard et al.   Annual Review of Biochemistry

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

(2016) Nicholas J. Haradhvala et al.   CELL

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair

(2016) Michael Ranes et al.   NUCLEIC ACIDS RESEARCH

Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency

(2016) Kate S. Reid-Bayliss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect

(2016) Hiva Fassihi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

The Yin and Yang of R-loop biology

(2015) Lorenzo Costantino et al.   CURRENT OPINION IN CELL BIOLOGY

Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans Primordial Germ Cells

(2015) Melina Butuči et al.   DEVELOPMENTAL CELL

The ERCC1 and ERCC4 (XPF) genes and gene products

(2015) Mandira Manandhar et al.   GENE

Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution

(2015) Jinchuan Hu et al.   GENES & DEVELOPMENT

Mutations in the TTDN1 Gene Are Associated with a Distinct Trichothiodystrophy Phenotype

(2015) Elizabeth R. Heller et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair

(2015) Chia-Lung Li et al.   MOLECULAR CELL

The CSB chromatin remodeler and CTCF architectural protein cooperate in response to oxidative stress

(2015) Robert J. Lake et al.   NUCLEIC ACIDS RESEARCH

Architecture of the human XPC DNA repair and stem cell coactivator complex

(2015) Elisa T. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H. pylori -Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-κB Target Gene Expression

(2015) Mara L. Hartung et al.   Cell Reports

The C-terminal region ofXpcis dispensable for the transcriptional activity of Oct3/4 in mouse embryonic stem cells

(2014) Shunsuke Ito et al.   FEBS LETTERS

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

(2014) K. Skourti-Stathaki et al.   GENES & DEVELOPMENT

High resolution mapping of modified DNA nucleobases using excision repair enzymes

(2014) D. Suzi Bryan et al.   GENOME RESEARCH

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

Understanding nucleotide excision repair and its roles in cancer and ageing

(2014) Jurgen A. Marteijn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In TFIIH, XPD Helicase Is Exclusively Devoted to DNA Repair

(2014) Jochen Kuper et al.   PLOS BIOLOGY

Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

(2013) Kazuya Kashiyama et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

(2013) Ismene Karakasilioti et al.   Cell Metabolism

Human and yeast DNA damage recognition complexes bind with high affinity DNA structures mimicking in size transcription bubble

(2013) Yuliya S. Krasikova et al.   JOURNAL OF MOLECULAR RECOGNITION

Cockayne syndrome: The expanding clinical and mutational spectrum

(2013) Vincent Laugel   MECHANISMS OF AGEING AND DEVELOPMENT

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

(2013) Nicola Crosetto et al.   NATURE METHODS

High-resolution characterization of CPD hotspot formation in human fibroblasts

(2013) A. G. Zavala et al.   NUCLEIC ACIDS RESEARCH

Xeroderma Pigmentosum:Man Deprived of His Right to Light

(2013) Subhash Mareddy et al.   TheScientificWorldJOURNAL

R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli

(2013) Hallie Wimberly et al.   Nature Communications

Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality

(2013) Arjan F. Theil et al.   PLoS Genetics

Oxidative DNA Damage and Nucleotide Excision Repair

(2012) Joost P.M. Melis et al.   ANTIOXIDANTS & REDOX SIGNALING

Shining a Light on Xeroderma Pigmentosum

(2012) John J. DiGiovanna et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A genome-wide 3C-method for characterizing the three-dimensional architectures of genomes

(2012) Zhijun Duan et al.   METHODS

XPG and XPF Endonucleases Trigger Chromatin Looping and DNA Demethylation for Accurate Expression of Activated Genes

(2012) Nicolas Le May et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria

(2012) I. Kamileri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotide excision repair: new tricks with old bricks

(2012) Irene Kamileri et al.   TRENDS IN GENETICS

A DNA Repair Complex Functions as an Oct4/Sox2 Coactivator in Embryonic Stem Cells

(2011) Yick W. Fong et al.   CELL

Transcription-blocking DNA damage in aging and longevity

(2011) George A. Garinis et al.   CELL CYCLE

Regulation of endonuclease activity in human nucleotide excision repair

(2011) Adebanke F. Fagbemi et al.   DNA REPAIR

A history of TFIIH: Two decades of molecular biology on a pivotal transcription/repair factor

(2011) Jean-Marc Egly et al.   DNA REPAIR

Replication protein A safeguards genome integrity by controlling NER incision events

(2011) René M. Overmeer et al.   JOURNAL OF CELL BIOLOGY

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

The perils of transcription

(2011) Mary Muers   NATURE REVIEWS GENETICS

Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast

(2011) A. S. Sperling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aire's Partners in the Molecular Control of Immunological Tolerance

(2010) Jakub Abramson et al.   CELL

Transcription-Dependent Cytosine Deamination Is a Novel Mechanism in Ultraviolet Light-Induced Mutagenesis

(2010) Giel Hendriks et al.   CURRENT BIOLOGY

Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair

(2010) P. T. Bradford et al.   JOURNAL OF MEDICAL GENETICS

NER Factors Are Recruited to Active Promoters and Facilitate Chromatin Modification for Transcription in the Absence of Exogenous Genotoxic Attack

(2010) Nicolas Le May et al.   MOLECULAR CELL

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

(2010) Michael C Haffner et al.   NATURE GENETICS

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

(2009) Chunru Lin et al.   CELL

CTCF: Master Weaver of the Genome

(2009) Jennifer E. Phillips et al.   CELL

Molecular insights into the recruitment of TFIIH to sites of DNA damage

(2009) Valentyn Oksenych et al.   EMBO JOURNAL

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

(2009) George A. Garinis et al.   NATURE CELL BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Differentiation Driven Changes in the Dynamic Organization of Basal Transcription Initiation

(2009) Giuseppina Giglia-Mari et al.   PLOS BIOLOGY

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

(2008) Li Fan et al.   CELL

Nucleotide excision repair deficient mouse models and neurological disease

(2008) Laura J. Niedernhofer   DNA REPAIR

Skin cancers, blindness, and anterior tongue mass in African brothers

(2008) Priya Mahindra et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair

(2008) J.-O. Andressoo et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA damage and ageing: new-age ideas for an age-old problem

(2008) George A. Garinis et al.   NATURE CELL BIOLOGY

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY