Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone Cell Receptor-Mediated Gene Expression

Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: implications for the treatment of rheumatoid arthritis

(2019) Chien-Chung Huang et al.   JOURNAL OF PINEAL RESEARCH

Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer

(2019) Galia Maik-Rachline et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual inhibitors of RAF-MEK-ERK and PI3K-PDK1-AKT pathways: Design, synthesis and preliminary anticancer activity studies of 3-substituted-5-(phenylamino) indolone derivatives

(2019) Zutao Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of MMPs and ADAM/ADAMTS

(2019) Charles J. Malemud   BIOCHEMICAL PHARMACOLOGY

Update on BRAF and MEK inhibition for treatment of melanoma in metastatic, unresectable, and adjuvant settings

(2019) Kristy Kummerow Broman et al.   Expert Opinion On Drug Safety

ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer

(2019) Iris C. Salaroglio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting ERK1/2 protein-serine/threonine kinases in human cancers

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis

(2018) Qianyun Feng et al.   BIOSCIENCE REPORTS

Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations

(2018) Matthew Dankner et al.   ONCOGENE

TPL2 kinase action and control of inflammation

(2018) Daqi Xu et al.   PHARMACOLOGICAL RESEARCH

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

(2018) Feifei Liu et al.   Acta Pharmaceutica Sinica B

Ustekinumab in psoriatic arthritis and related phenotypes

(2018) Isobel Dobbin-Sears et al.   Therapeutic Advances in Chronic Disease

Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents

(2018) Usama M. Ammar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Downregulated microRNA-340-5p promotes proliferation and inhibits apoptosis of chondrocytes in osteoarthritis mice through inhibiting the extracellular signal-regulated kinase signaling pathway by negatively targeting the FMOD gene

(2018) Weikai Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis

(2018) Jason E. Hawkes et al.   JOURNAL OF IMMUNOLOGY

The nuclear translocation of mitogen-activated protein kinases: molecular mechanisms and use as novel therapeutic target

(2018) Karen Flores et al.   NEUROENDOCRINOLOGY

MicroRNAs and Osteoarthritis

(2018) Charles Malemud   Cells

The role of secukinumab in the treatment of psoriatic arthritis and ankylosing spondylitis

(2018) Leticia Garcia-Montoya et al.   Therapeutic Advances in Musculoskeletal Disease

Guselkumab: A Review in Moderate to Severe Plaque Psoriasis

(2018) Zaina T. Al-Salama et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

BRAF kinase inhibitors for treatment of melanoma: developments from early-stage animal studies to Phase II clinical trials

(2018) Taku Fujimura et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A compendium of ERK targets

(2017) Evrim B. Ünal et al.   FEBS LETTERS

FOXO Signaling Pathways as Therapeutic Targets in Cancer

(2017) Mohd Farhan et al.   International Journal of Biological Sciences

ERK signalling as a regulator of cell motility

(2017) Susumu Tanimura et al.   JOURNAL OF BIOCHEMISTRY

The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2

(2017) A. Jane Bardwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between Smad2/3 and specific isoforms of ERK in TGF-β1-induced TIMP-3 expression in rat chondrocytes

(2017) Yanhui Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TargetingBRAF‐Mutant Non‐Small Cell Lung Cancer: From Molecular Profiling to Rationally Designed Therapy

(2017) Christina S. Baik et al.   ONCOLOGIST

Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes

(2017) G. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas

(2017) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Targeting TRK family proteins in cancer

(2017) Yekaterina B. Khotskaya et al.   PHARMACOLOGY & THERAPEUTICS

Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2

(2017) Andrea Piserchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p38γ and p38δ: From Spectators to Key Physiological Players

(2017) Ana Cuenda et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2

(2017) Maria Perander et al.   Scientific Reports

Mutant B-Raf Kinase Inhibitors as Anticancer Agents

(2016) Vivek Asati et al.   Anti-Cancer Agents in Medicinal Chemistry

Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes

(2016) Lomeli R. Carpio et al.   CONNECTIVE TISSUE RESEARCH

The dynamic subcellular localization of ERK: mechanisms of translocation and role in various organelles

(2016) Ehud Wainstein et al.   CURRENT OPINION IN CELL BIOLOGY

Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase

(2016) Sebastian Kalamajski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)

(2016) Andrew M. Kidger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold

(2016) Itziar M. D. Posada et al.   PLoS One

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Recent progress on MAP kinase pathway inhibitors

(2015) David E. Uehling et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ERK1/2 can feedback-regulate cellular MEK1/2 levels

(2015) Seung-Keun Hong et al.   CELLULAR SIGNALLING

Biologic basis of osteoarthritis

(2015) Charles J. Malemud   CURRENT OPINION IN RHEUMATOLOGY

The PI3K/Akt/PTEN/mTOR pathway: a fruitful target for inducing cell death in rheumatoid arthritis?

(2015) Charles J Malemud   Future Medicinal Chemistry

The Involvement of Mutual Inhibition of ERK and mTOR in PLCγ1-Mediated MMP-13 Expression in Human Osteoarthritis Chondrocytes

(2015) Zejun Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer

(2015) Dustin A. Deming et al.   INVESTIGATIONAL NEW DRUGS

Spred1, a Suppressor of the Ras–ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells

(2015) Mayu Suzuki et al.   JOURNAL OF IMMUNOLOGY

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Regulation of RAF protein kinases in ERK signalling

(2015) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms

(2015) Pui-Kei Wu et al.   SEMINARS IN ONCOLOGY

RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action

(2015) Julien Masliah-Planchon et al.   Oncotarget

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

ATGs

(2014) Nuria Martinez-Lopez et al.   Autophagy

The Biology and Clinical Development of MEK Inhibitors for Cancer

(2014) Jason J. Luke et al.   DRUGS

Sos1 regulates sustained TCR-mediated Erk activation

(2014) Mateusz Poltorak et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Raf-interactome in tuning the complexity and diversity of Raf function

(2014) Su An et al.   FEBS Journal

MEK1/2 inhibitors in the treatment of gynecologic malignancies

(2014) Caela R. Miller et al.   GYNECOLOGIC ONCOLOGY

Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma

(2014) Zhou Luan et al.   Molecular Cancer

The clinical development of MEK inhibitors

(2014) Yujie Zhao et al.   Nature Reviews Clinical Oncology

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphoprotein enriched in astrocytes (PEA)-15: A potential therapeutic target in multiple disease states

(2014) Fiona H. Greig et al.   PHARMACOLOGY & THERAPEUTICS

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

PRO40 Is a Scaffold Protein of the Cell Wall Integrity Pathway, Linking the MAP Kinase Module to the Upstream Activator Protein Kinase C

(2014) Ines Teichert et al.   PLoS Genetics

Osteoblast-Chondrocyte Interactions in Osteoarthritis

(2014) David M. Findlay et al.   Current Osteoporosis Reports

Prostaglandin D2 induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways

(2013) Li Yue et al.   BONE

Mind the IQGAP

(2013) Berta Sanchez-Laorden et al.   CANCER CELL

Concomitant activation of the PI3K/Akt and ERK1/2 signalling is involved in cyclic compressive force-induced IL-6 secretion in MLO-Y4 cells

(2013) Jian Yin et al.   CELL BIOLOGY INTERNATIONAL

Hierarchical scaffolding of an ERK1/2 activation pathway

(2013) Susanne Vetterkind et al.   Cell Communication and Signaling

Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation

(2013) Hui-ming Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of Son of sevenless by the membrane-actin linker protein ezrin

(2013) K. J. Geissler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints

(2012) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Angiotensin II induces the production of MMP-3 and MMP-13 through the MAPK signaling pathways via the AT1 receptor in osteoblasts

(2012) Kumiko Nakai et al.   BIOCHIMIE

IκB kinase regulation of the TPL-2/ERK MAPK pathway

(2012) Thorsten Gantke et al.   IMMUNOLOGICAL REVIEWS

Genetic and molecular control of osterix in skeletal formation

(2012) Krishna M. Sinha et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PTEN regulation of ERK1/2 signaling in cancer

(2012) Mahandranauth A. Chetram et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes -- Possible Pathogenic Role in Osteoarthritis

(2012) I. PRASADAM et al.   JOURNAL OF RHEUMATOLOGY

Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes

(2012) T. Saito et al.   OSTEOARTHRITIS AND CARTILAGE

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

(2012) Kenneth D. Rice et al.   ACS Medicinal Chemistry Letters

Osterix is regulated by Erk1/2 during osteoblast differentiation

(2011) You Hee Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interactions between Kinase Scaffold MP1/p14 and Its Endosomal Anchoring Protein p18

(2011) James Magee et al.   BIOCHEMISTRY

MEK5/ERK5 pathway: The first fifteen years

(2011) Barbara A. Drew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting the Extracellular Signal-Regulated Kinase Pathway in Cancer Therapy

(2011) Michiaki Kohno et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

IL-6/IL-6 receptor system and its role in physiological and pathological conditions

(2011) Masahiko Mihara et al.   CLINICAL SCIENCE

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

(2011) Markus F. Neurath et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The ETS Family Transcription Factor ELK-1 Regulates Induction of the Cell Cycle-regulatory Genep21Waf1/Cip1and theBAXGene in Sodium Arsenite-exposed Human Keratinocyte HaCaT Cells

(2011) Soon Young Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts

(2010) Indira Prasadam et al.   ARTHRITIS AND RHEUMATISM

High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1

(2010) Misato Hashizume et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

Emerging MEK inhibitors

(2010) James A McCubrey et al.   EXPERT OPINION ON EMERGING DRUGS

The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

(2010) Rie Matsunaga-Udagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I collagen promotes proliferation and osteogenesis of human mesenchymal stem cells via activation of ERK and Akt pathways

(2010) Kuo-Shu Tsai et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes

(2010) Frank Beier et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

Mechanical impact induces cartilage degradation via mitogen activated protein kinases

(2010) L. Ding et al.   OSTEOARTHRITIS AND CARTILAGE

The ERK signaling cascade-Views from different subcellular compartments

(2009) Zhong Yao et al.   BIOFACTORS

Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast differentiation via MAPK signalling pathway involving ERK1/2

(2009) Indira Prasadam et al.   BONE

Targeting the RAF–MEK–ERK pathway in cancer therapy

(2009) Clara Montagut et al.   CANCER LETTERS

IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling

(2009) H Huang et al.   CELL DEATH AND DIFFERENTIATION

Targeting JAK/STAT Signaling Pathway in Inflammatory Diseases

(2009) Charles Malemud et al.   Current Signal Transduction Therapy

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

(2009) Colin D. White et al.   FEBS LETTERS

Signalling pathways in alcohol-induced liver inflammation

(2009) Pranoti Mandrekar et al.   JOURNAL OF HEPATOLOGY

Spred1 Is Required for Synaptic Plasticity and Hippocampus-Dependent Learning

(2009) E. Denayer et al.   JOURNAL OF NEUROSCIENCE

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

(2008) Stephen M. Keyse   CANCER AND METASTASIS REVIEWS

Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor

(2008) Alexey E Granovsky et al.   CELL RESEARCH

Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia

(2008) Xuehui Yang et al.   DEVELOPMENTAL BIOLOGY

Angiotensin II accelerates osteoporosis by activating osteoclasts

(2008) Hideo Shimizu et al.   FASEB JOURNAL

Does MK5 reconcile classical and atypical MAP kinases?

(2008) Maria Perander   Frontiers in Bioscience-Landmark

Cotargeting survival signaling pathways in cancer

(2008) Steven Grant   JOURNAL OF CLINICAL INVESTIGATION

IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade

(2008) Hisashi Nojima et al.   NATURE CELL BIOLOGY

Angiotensin II induces matrix metalloproteinase-9 expression via a nuclear factor-kappaB-dependent pathway in vascular smooth muscle cells

(2008) Rui-wei Guo et al.   REGULATORY PEPTIDES