Intrauterine programming of obesity and type 2 diabetes

Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring

(2019) Laura Butruille et al.   INTERNATIONAL JOURNAL OF OBESITY

Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta

(2019) Perrine Nogues et al.   Clinical Epigenetics

Higher Maternal Diet Quality during Pregnancy and Lactation Is Associated with Lower Infant Weight-For-Length, Body Fat Percent, and Fat Mass in Early Postnatal Life

(2019) Muna Tahir et al.   Nutrients

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study

(2019) Chantel L. Martin et al.   Epigenetics

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

(2018) Siroon Bekkering et al.   CELL

Specific synbiotics in early life protect against diet-induced obesity in adult mice

(2018) Mona Mischke et al.   DIABETES OBESITY & METABOLISM

Association between serum arsenic levels and gestational diabetes mellitus: A population-based birth cohort study

(2018) Xun Xia et al.   ENVIRONMENTAL POLLUTION

Exposure to arsenic in tap water and gestational diabetes: A French semi-ecological study

(2018) Cécile Marie et al.   ENVIRONMENTAL RESEARCH

Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes

(2018) Maria C Magnus et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Maternal smoking during pregnancy and offspring overweight: is there a dose–response relationship? An individual patient data meta-analysis

(2018) Lucia Albers et al.   INTERNATIONAL JOURNAL OF OBESITY

Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

(2018) Wenfei Sun et al.   NATURE MEDICINE

DNA methylation mediates the effect of maternal cognitive appraisal of a disaster in pregnancy on the child’s C-peptide secretion in adolescence: Project Ice Storm

(2018) Lei Cao-Lei et al.   PLoS One

Maternal virus infections in pregnancy and type 1 diabetes in their offspring: Systematic review and meta-analysis of observational studies

(2018) Digby W. Allen et al.   REVIEWS IN MEDICAL VIROLOGY

Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice

(2018) Lindsey M. Berends et al.   DIABETOLOGIA

Maternal infection during pregnancy and type 1 diabetes mellitus in offspring: a systematic review and meta-analysis

(2018) Y. Yue et al.   EPIDEMIOLOGY AND INFECTION

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice

(2018) Adam J. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update of the Healthy Eating Index: HEI-2015

(2018) Susan M. Krebs-Smith et al.   Journal of the Academy of Nutrition and Dietetics

Paternal Exercise Improves Glucose Metabolism in Adult Offspring

(2018) Kristin I. Stanford et al.   DIABETES

Association between maternal urinary speciated arsenic concentrations and gestational diabetes in a cohort of Canadian women

(2018) Jillian Ashley-Martin et al.   ENVIRONMENT INTERNATIONAL

Chorioamnionitis exposure remodels the unique histone modification landscape of neonatal monocytes and alters the expression of immune pathway genes

(2018) Jennifer Bermick et al.   FEBS Journal

Molecular aspects of pancreatic β-cell dysfunction: Oxidative stress, microRNA, and long noncoding RNA

(2018) Mohammad Javad Saeedi Borujeni et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine

(2018) Paul Zimmet et al.   Nature Reviews Endocrinology

The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD

(2018) Taylor K. Soderborg et al.   Nature Communications

Exposure to the Chinese famine of 1959–61 in early life and long-term health conditions: a systematic review and meta-analysis

(2017) Chihua Li et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study

(2017) George Bedu-Addo et al.   JOURNAL OF INFECTION

Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring

(2017) Wojciech Trzepizur et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

(2017) Line Hjort et al.   Clinical Epigenetics

A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue

(2017) Juliana de Almeida Faria et al.   Scientific Reports

Exercise rescues obese mothers’ insulin sensitivity, placental hypoxia and male offspring insulin sensitivity

(2017) Denise S. Fernandez-Twinn et al.   Scientific Reports

Windows of Opportunity for Lifestyle Interventions to Prevent Gestational Diabetes Mellitus

(2016) Suzanne Phelan   AMERICAN JOURNAL OF PERINATOLOGY

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

(2016) Boris Novakovic et al.   CELL

Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity

(2016) Peter Kühnen et al.   Cell Metabolism

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring

(2016) Maria Z. Alfaradhi et al.   ENDOCRINOLOGY

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Diabetic pregnancy activates the innate immune response through TLR5 or TLR1/2 on neonatal monocyte

(2016) Sakika Yanai et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

(2016) Christoph Bock et al.   NATURE BIOTECHNOLOGY

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Preconceptional and maternal obesity: epidemiology and health consequences

(2016) Lucilla Poston et al.   Lancet Diabetes & Endocrinology

Associations of maternal prepregnancy body mass index and gestational weight gain with cardio-metabolic risk factors in adolescent offspring: a prospective cohort study

(2015) R Gaillard et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Readers, Writers, and Erasers

(2015) Thomas G. Gillette et al.   CIRCULATION RESEARCH

Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

(2015) L. L. Wu et al.   DEVELOPMENT

Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach

(2015) Keren Agay-Shay et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

(2015) T. Ronn et al.   HUMAN MOLECULAR GENETICS

Cohort Profile: The Kiang West Longitudinal Population Study (KWLPS)—a platform for integrated research and health care provision in rural Gambia

(2015) Branwen J. Hennig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

(2015) Leanne K Küpers et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Association between type 2 diabetes and prenatal exposure to the Ukraine famine of 1932–33: a retrospective cohort study

(2015) L H Lumey et al.   Lancet Diabetes & Endocrinology

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

(2015) Rebecca C. Richmond et al.   HUMAN MOLECULAR GENETICS

Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice

(2014) Adam J. Watkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

(2014) Fan Guo et al.   Cell Stem Cell

Exercise Before and During Pregnancy Prevents the Deleterious Effects of Maternal High-Fat Feeding on Metabolic Health of Male Offspring

(2014) Kristin I. Stanford et al.   DIABETES

Fetal Exposure to Parental Smoking and the Risk of Type 2 Diabetes in Adult Women

(2014) Vincent W.V. Jaddoe et al.   DIABETES CARE

Prepubertal start of father’s smoking and increased body fat in his sons: further characterisation of paternal transgenerational responses

(2014) Kate Northstone et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Overweight and CpG methylation of the Pomc promoter in offspring of high-fat-diet-fed dams are not “reprogrammed” by regular chow diet in rats

(2014) Asaf Marco et al.   FASEB JOURNAL

Infant antibiotic exposure and the development of childhood overweight and central adiposity

(2014) M B Azad et al.   INTERNATIONAL JOURNAL OF OBESITY

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA methylation signatures link prenatal famine exposure to growth and metabolism

(2014) Elmar W. Tobi et al.   Nature Communications

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

(2014) Paula Dominguez-Salas et al.   Nature Communications

High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model

(2014) Jun Ma et al.   Nature Communications

Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms

(2014) Denise S. Fernandez-Twinn et al.   Molecular Metabolism

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

(2013) Paula Dominguez-Salas et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Prenatal stress due to a natural disaster predicts insulin secretion in adolescence

(2013) Kelsey N. Dancause et al.   EARLY HUMAN DEVELOPMENT

Postnatal stability, tissue, and time specific effects ofAHRRmethylation change in response to maternal smoking in pregnancy

(2013) Boris Novakovic et al.   Epigenetics

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

PPARGC1A DNA methylation in subcutaneous adipose tissue in low birth weight subjects — impact of 5days of high-fat overfeeding

(2013) Linn Gillberg et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pre-Pregnancy Body Mass Index in Relation to Infant Birth Weight and Offspring Overweight/Obesity: A Systematic Review and Meta-Analysis

(2013) Zhangbin Yu et al.   PLoS One

Virus Infections in Type 1 Diabetes

(2013) K. T. Coppieters et al.   Cold Spring Harbor Perspectives in Medicine

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

(2013) Tina Rönn et al.   PLoS Genetics

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes

(2012) D Ferland-McCollough et al.   CELL DEATH AND DIFFERENTIATION

Transgenerational Glucose Intolerance WithIgf2/H19Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia

(2012) Guo-Lian Ding et al.   DIABETES

450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy

(2012) Bonnie R. Joubert et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders: A National Toxicology Program Workshop Review

(2012) Mamta Behl et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning

(2012) Ghazala Begum et al.   FASEB JOURNAL

Catch-up growth following intra-uterine growth-restriction programmes an insulin-resistant phenotype in adipose tissue

(2012) L M Berends et al.   INTERNATIONAL JOURNAL OF OBESITY

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study

(2012) Jiong Li et al.   PLoS One

Epigenetic changes in the hypothalamic pro-opiomelanocortin gene: A mechanism linking maternal undernutrition to obesity in the offspring?

(2011) Adam Stevens et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endocrine disruptors in the etiology of type 2 diabetes mellitus

(2011) Paloma Alonso-Magdalena et al.   Nature Reviews Endocrinology

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

(2011) I. Sandovici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo DNA methylation: a germ cell perspective

(2011) Sébastien A. Smallwood et al.   TRENDS IN GENETICS

Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men

(2010) A. C. Alibegovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early life nutrition and metabolic programming

(2010) Denise S. Fernandez-Twinn et al.   Annals of the New York Academy of Sciences

Association of Maternal Weight Gain in Pregnancy With Offspring Obesity and Metabolic and Vascular Traits in Childhood

(2010) Abigail Fraser et al.   CIRCULATION

Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes

(2010) Zivjena Vucetic et al.   ENDOCRINOLOGY

Deoxyribonucleic Acid Methylation and Gene Expression ofPPARGC1Ain Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner

(2010) Charlotte Brøns et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles

(2010) Robert A. Waterland et al.   PLoS Genetics

Prospects for Epigenetic Epidemiology

(2009) D. L. Foley et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Prenatal Stress or High-Fat Diet Increases Susceptibility to Diet-Induced Obesity in Rat Offspring

(2009) K. L.K. Tamashiro et al.   DIABETES

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

Exercise-induced histone modifications in human skeletal muscle

(2009) Sean L. McGee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Epigenetic mechanisms that underpin metabolic and cardiovascular diseases

(2009) Peter D. Gluckman et al.   Nature Reviews Endocrinology

Viral Trigger for Type 1 Diabetes: Pros and Cons

(2008) C. M. Filippi et al.   DIABETES

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

(2008) Jun H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information

(2008) Armelle Corpet et al.   TRENDS IN CELL BIOLOGY