Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a 6-month exercise intervention

(2014) T. Rönn et al.   Acta Physiologica

Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs

(2014) Wilma T. Steegenga et al.   AGE

Meta-analysis of human methylation data for evidence of sex-specific autosomal patterns

(2014) Nina S McCarthy et al.   BMC GENOMICS

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

(2014) Elin Hall et al.   BMC Medicine

Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes

(2014) E. Nilsson et al.   DIABETES

Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding

(2014) Stine C. Jacobsen et al.   DIABETOLOGIA

Association of KCNQ1 and KLF14 polymorphisms and risk of type 2 diabetes mellitus: A global meta-analysis

(2014) Jinjin Wang et al.   HUMAN IMMUNOLOGY

DNA methylation and body-mass index: a genome-wide analysis

(2014) Katherine J Dick et al.   LANCET

Hemoglobin A1c in Nondiabetic Patients: An Independent Predictor of Coronary Artery Disease and Its Severity

(2014) Naveen Garg et al.   MAYO CLINIC PROCEEDINGS

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

(2013) Rafał Kozieł et al.   BIOCHEMICAL JOURNAL

Gene-set analysis is severely biased when applied to genome-wide methylation data

(2013) Paul Geeleher et al.   BIOINFORMATICS

Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer

(2013) Z. Xu et al.   CARCINOGENESIS

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

(2013) A. E. Teschendorff et al.   HUMAN MOLECULAR GENETICS

Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants

(2013)   LANCET

PPARGC1A DNA methylation in subcutaneous adipose tissue in low birth weight subjects — impact of 5days of high-fat overfeeding

(2013) Linn Gillberg et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor

(2013) Francesca Calabrese et al.   NEUROBIOLOGY OF AGING

Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?

(2013) Linn Gillberg et al.   PLoS One

Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan

(2013) Åsa Johansson et al.   PLoS One

The GTPase Rab37 Participates in the Control of Insulin Exocytosis

(2013) Sanda Ljubicic et al.   PLoS One

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array

(2013) Magda E Price et al.   Epigenetics & Chromatin

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

(2013) Tina Rönn et al.   PLoS Genetics

Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

(2013) Kenneth Day et al.   GENOME BIOLOGY

Methylation ofELOVL2gene as a new epigenetic marker of age

(2012) Paolo Garagnani et al.   AGING CELL

Adiposopathy, Diabetes Mellitus, and Primary Prevention of Atherosclerotic Coronary Artery Disease: Treating “Sick Fat” Through Improving Fat Function with Antidiabetes Therapies

(2012) Harold E. Bays   AMERICAN JOURNAL OF CARDIOLOGY

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

(2012) Andrew E. Teschendorff et al.   BIOINFORMATICS

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes

(2012) M. D. Nitert et al.   DIABETES

First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle

(2012) T. Elgzyri et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes

(2012) Beatrice T. Yang et al.   MOLECULAR ENDOCRINOLOGY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility

(2012) Lovisa E. Reinius et al.   PLoS One

Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes

(2012) Rasmus Ribel-Madsen et al.   PLoS One

Distinct DNA methylomes of newborns and centenarians

(2012) H. Heyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

(2012) Jordana T. Bell et al.   PLoS Genetics

POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway

(2011) J H Cho et al.   CELL DEATH AND DIFFERENTIATION

Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation

(2011) Allison M. Cotton et al.   HUMAN GENETICS

Dynamics of human adipose lipid turnover in health and metabolic disease

(2011) Peter Arner et al.   NATURE

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

(2011) Kerrin S Small et al.   NATURE GENETICS

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

(2011) Lei Chen et al.   Nature Reviews Endocrinology

Epigenome-wide association studies for common human diseases

(2011) Vardhman K. Rakyan et al.   NATURE REVIEWS GENETICS

ITIH-5 Expression in Human Adipose Tissue Is Increased in Obesity

(2011) Åsa Anveden et al.   Obesity

Mieap, a p53-Inducible Protein, Controls Mitochondrial Quality by Repairing or Eliminating Unhealthy Mitochondria

(2011) Noriaki Kitamura et al.   PLoS One

Insufficient DNA methylation affects healthy aging and promotes age-related health problems

(2011) Liang Liu et al.   Clinical Epigenetics

Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

(2010) Pan Du et al.   BMC BIOINFORMATICS

HLA DPA1, DPB1 Alleles and Haplotypes Contribute to the Risk Associated With Type 1 Diabetes

(2010) Michael D. Varney et al.   DIABETES

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets

(2010) B. T. Yang et al.   DIABETOLOGIA

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

(2010) A. E. Teschendorff et al.   GENOME RESEARCH

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

(2010) V. K. Rakyan et al.   GENOME RESEARCH

Deoxyribonucleic Acid Methylation and Gene Expression ofPPARGC1Ain Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner

(2010) Charlotte Brøns et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose Tissue Has Aberrant Morphology and Function in PCOS: Enlarged Adipocytes and Low Serum Adiponectin, But Not Circulating Sex Steroids, Are Strongly Associated with Insulin Resistance

(2010) Louise Mannerås-Holm et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Glycated Hemoglobin, Diabetes, and Cardiovascular Risk in Nondiabetic Adults

(2010) Elizabeth Selvin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetics and maternal nutrition: nature v. nurture

(2010) Rebecca Simmons   PROCEEDINGS OF THE NUTRITION SOCIETY

Hypoxia-Inducible Factor-3α Functions as an Accelerator of 3T3-L1 Adipose Differentiation

(2009) Misaki Hatanaka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

Are There Any Sensitive and Specific Sex Steroid Markers for Polycystic Ovary Syndrome?

(2009) Elisabet Stener-Victorin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DNA methylation profiles in monozygotic and dizygotic twins

(2009) Zachary A Kaminsky et al.   NATURE GENETICS

The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls

(2009) Marco P. Boks et al.   PLoS One

Variant near ADAMTS9 Known to Associate with Type 2 Diabetes Is Related to Insulin Resistance in Offspring of Type 2 Diabetes Patients—EUGENE2 Study

(2009) Trine Welløv Boesgaard et al.   PLoS One

An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer

(2009) Andrew E. Teschendorff et al.   PLoS One

lumi: a pipeline for processing Illumina microarray

(2008) P. Du et al.   BIOINFORMATICS

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle

(2008) T. Rönn et al.   DIABETOLOGIA

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)

(2008) V. K. Rakyan et al.   GENOME RESEARCH

Mitochondrial Function in Skeletal Muscle Is Normal and Unrelated to Insulin Action in Young Men Born with Low Birth Weight

(2008) Charlotte Brøns et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE