Article
Cell Biology
In-Ho Seo, Hyuk Soo Eun, Ja Kyung Kim, Hoyoung Lee, Seongju Jeong, Seong Jin Choi, Jeewon Lee, Byung Seok Lee, Seok Hyun Kim, Woo Sun Rou, Dong Hyeon Lee, Won Kim, Su-Hyung Park, Eui-Cheol Shin
Summary: IL-15 upregulates CCR5 in memory CD8(+) T cells, enhancing their migration, while the upregulation is abrogated by TCR stimulation. CCR5 signals increase proliferation and cytotoxic protein expression in IL-15-treated memory CD8(+) T cells, associating with severe liver injury in patients with acute hepatitis A.
Article
Immunology
Junghwa Lee, Kyungmin Lee, Hyeonjin Bae, Kunhee Lee, Solhwi Lee, Junhui Ma, Kyungjo Jo, Ijun Kim, ByulA Jee, Minyong Kang, Se Jin Im
Summary: In chronic infections and cancer, exhausted CD8 T cells display heterogeneous subpopulations. TCF1+PD-1+ progenitor exhausted CD8 T cells (Tpex) have the ability to self-renew and differentiate into Tim-3+PD-1+ terminally differentiated CD8 T cells. Tpex cells are crucial for maintaining a pool of antigen-specific CD8 T cells during persistent antigenic stimulation and are responsive to PD-1-targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Qian Wu, Xiao Yue, Huashan Liu, Yaxi Zhu, Haoxian Ke, Xin Yang, Shi Yin, Zhihao Li, Yunfeng Zhang, Tuo Hu, Ping Lan, Xianrui Wu
Summary: Through next-generation sequencing, we identified MAP7D2 as a potential therapeutic target to improve the efficacy of immune checkpoint inhibitors (ICIs) for microsatellite stable (MSS) colorectal cancer (CRC) therapy. MAP7D2 expression was increased in MSS CRC and negatively correlated with the presence of antitumor T lymphocytes. Knockdown of MAP7D2 significantly enhanced CD8+ CTLs infiltration and improved the efficacy of ICIs in MSS CRC murine models. Targeting MAP7D2 may present a novel approach for antitumor immunotherapy in MSS CRC.
Article
Immunology
Fiona Watkinson, Sandeep Krishan Nayar, Aradhana Rani, Christina A. Sakellariou, Oussama Elhage, Efthymia Papaevangelou, Prokar Dasgupta, Christine Galustian
Summary: IL-15 is more effective than IL-2 in enhancing the cellular growth of NK, NKT, and CD8 T cells, as well as increasing the expression of TERT in NK and NKT cells significantly. JAK/STAT and PI3K/AKT pathways are important in IL-15 induced upregulation of TERT in NK and NKT cells, while all three pathways are involved in CD8 T cell TERT expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Seongju Jeong, Minwoo Jeon, Hoyoung Lee, So-Young Kim, Su-Hyung Park, Eui-Cheol Shin
Summary: In bystander activation, memory CD8(+) T cells unrelated to the infecting microbes are activated without cognate Ags. This study investigates bystander activation of OT-1 memory cells in a mouse model of influenza infection. The findings reveal that IL-15 is critical for bystander activation and upregulation of IFITM3 can be used as a marker for bystander-activated memory CD8(+) T cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Brooks Hopkins, Justin Fisher, Meiping Chang, Xiaoyan Tang, Zhimei Du, William J. Kelly, Zuyi Huang
Summary: This study conducted experiments on the growth of different T cell subsets under different combinations of IL-2, IL-7, and IL-15, developed mathematical models to predict optimal growth conditions, and analyzed RNA sequencing data to study gene networks influencing growth pathways.
Article
Biology
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Summary: In this study, it was identified that Tregs limit the availability of IL-2, thereby suppressing the formation of a previously uncharacterized subset of antigen-stimulated KILR CD8(+) effector T cells. These KILR CD8(+) T cells exhibit superior cell-killing abilities and can be induced by the administration of agonistic IL-2 immunocomplexes. This research has potential implications for immunotherapy targeting these cells in humans.
Article
Oncology
Francesca Sozio, Tiziana Schioppa, Mattia Laffranchi, Valentina Salvi, Nicola Tamassia, Francisco M. Bianchetto-Aguilera, Laura Tiberio, Raffaella Bonecchi, Daniela Bosisio, Marc Parmentier, Barbara Bottazzi, Roberto Leone, Eleonora Russo, Giovanni Bernardini, Stefano Garofalo, Cristina Limatola, Angela Gismondi, Giuseppe Sciume, Alberto Mantovani, Annalisa Del Prete, Silvano Sozzani
Summary: Patterns of receptors play a crucial role in regulating the homing of leukocytes. A study reveals that the CCRL2/chemerin/CMKLR1 axis acts as a selective pathway for the homing of NK cells to the lung. Inactivation of CCRL2 or its ligand chemerin promotes lung tumor growth by affecting the recruitment of NK cells, while other receptors identified in lung-infiltrating NK cells are dispensable for this process.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Immunology
Xiyue Zhang, Yusi Zhang, He Liu, Kang Tang, Chunmei Zhang, Meng Wang, Manling Xue, Xiaozhou Jia, Haifeng Hu, Na Li, Ran Zhuang, Boquan Jin, Fanglin Zhang, Yun Zhang, Ying Ma
Summary: This study aimed to investigate the effect of bystander-activated CD8+ T cell responses in HTNV infection. An in vitro infection model was established to mimic endothelium injury in HFRS patients. The results showed that HTNV infection could activate EBV or CMV-specific CD8+ T cells and induce high levels of IL-15 production in HTNV-infected HUVECs, which were correlated with disease severity and NKG2D expression on bystander-activated CD8+ T cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Sarah Schaefer, Alma Zernecke
Summary: CD8(+) T cells play an important role in atherosclerosis by regulating inflammation, cell death, and plaque formation, showing therapeutic potential in treating atherosclerosis.
Article
Biochemistry & Molecular Biology
Marta Fortunato, Giada Amodio, Silvia Gregori
Summary: Tolerogenic dendritic cells (tolDC) play a central role in immune homeostasis and peripheral tolerance. We developed a protocol to generate genetically engineered tolDC overexpressing IL-10 (DCIL-10) and found that they can modulate cytotoxic CD8(+) T cell responses by reducing proliferation and activation, and inducing anergic CD8(+) T cells without signs of exhaustion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ella Bhagyaraj, Hongbin Wang, Xinghong Yang, Carol Hoffman, Ali Akgul, Zakia Goodwin, David W. Pascual
Summary: znBAZ infection induces an increase and activation of lung NK cells in mice, which play a crucial role in promoting lung DC activation, migration, and the development of protective CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Fernando Fernandez-Banares, Natalia Lopez-Palacios, Maria Corzo, Beatriz Arau, Mercedes Rubio, Marta Fernandez-Prieto, Eva Tristan, Mar Pujals, Sergio Farrais, Saul Horta, Juana Maria Hernandez, Marta Gomez-Perosanz, Pedro A. Reche, Maria Esteve, Concepcion Nunez
Summary: The study found significant differences in the percentage of CD8(+) and TCR gamma delta(+) cell subsets between CD patients and non-CD subjects after a 3-day gluten challenge. Measuring activated CD8(+) T cells provided highly accurate CD diagnosis with 95% specificity and 97% sensitivity, similar to IFN-gamma ELISPOT results.
Article
Cell Biology
Xuyue Zhou, Yu Hu, Lingxi Liu, Lihao Liu, Hongying Chen, Dan Huang, Mei Ju, Chao Luan, Kun Chen, Jiaan Zhang
Summary: This study found that mast cells play a role in exacerbating skin inflammation in psoriasis, by regulating the inflammatory state and immune homeostasis. The results suggest that targeting mast cell homeostasis could be a potential therapeutic strategy for psoriasis.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Gilbert Aaron Lee, Nan-Shih Liao
Summary: The homeostasis of CD8+CD122+ T cells requires varying levels of IL-15 trans-presentation to support their stability.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Sylvie Amu, Rebecka Lantto Graham, Yonas Bekele, Aikaterini Nasi, Carina Bengtsson, Bence Rethi, Sam Sorial, Genny Meini, Maurizio Zazzi, Bo Hejdeman, Francesca Chiodi
Article
Virology
Farideh Sabri, Alejandro Prados, Raquel Munoz-Fernandez, Rebecka Lantto, Pablo Fernandez-Rubio, Aikaterini Nasi, Sylvie Amu, Jan Albert, Enrique Garcia Olivares, Francesca Chiodi
Article
Immunology
Aikaterini Nasi, Sylvie Amu, Marten Gothlin, Marianne Jansson, Noemi Nagy, Francesca Chiodi, Bence Rethi
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Francesca Chiodi, Yonas Bekele, Rebecka Lantto Graham, Aikaterini Nasi
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Stefan Petkov, Elizaveta Starodubova, Anastasia Latanova, Athina Kilpelainen, Oleg Latyshev, Simons Svirskis, Britta Wahren, Francesca Chiodi, Ilya Gordeychuk, Maria Isaguliants
Article
Multidisciplinary Sciences
A. A. Latanova, S. Petkov, A. Kilpelainen, J. Jansons, O. E. Latyshev, Y. V. Kuzmenko, J. Hinkula, M. A. Abakumov, V. T. Valuev-Elliston, M. Gomelsky, V. L. Karpov, F. Chiodi, B. Wahren, D. Y. Logunov, E. S. Starodubova, M. G. Isaguliants
SCIENTIFIC REPORTS
(2018)
Editorial Material
Immunology
Francesca Chiodi, Gabriella Scarlatti
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Yonas Bekele, Rebecka Lantto Graham, Sandra Soeria-Atmadja, Aikaterini Nasi, Maurizio Zazzi, Ilaria Vicenti, Lars Naver, Anna Nilsson, Francesca Chiodi
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Yonas Bekele, Desalegn Yibeltal, Kidist Bobosha, Temesgen E. Andargie, Mahlet Lemma, Meseret Gebre, Eyasu Mekonnen, Abiy Habtewold, Anna Nilsson, Abraham Aseffa, Rawleigh Howe, Francesca Chiodi
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Yonas Bekele, Mahlet Lemma, Kidist Bobosha, Desalegn Yibeltal, Aikaterini Nasi, Meseret Gebre, Anna Nilsson, Abraham Aseffa, Rawleigh Howe, Francesca Chiodi
Article
Multidisciplinary Sciences
Smritee Dabee, Shaun L. Barnabas, Katie S. Lennard, Shameem Z. Jaumdally, Hoyam Gamieldien, Christina Balle, Anna-Ursula Happel, Brandon D. Murugan, Anna-Lise Williamson, Nonhlanhla Mkhize, Janan Dietrich, David A. Lewis, Francesca Chiodi, Thomas J. Hope, Robin Shattock, Glenda Gray, Linda-Gail Bekker, Heather B. Jaspan, Jo-Ann S. Passmore
Article
Immunology
Yonas Bekele, Jay A. Berzofsky, Francesca Chiodi
Summary: HIV-1-infected individuals exhibit suboptimal response to HBV vaccines and poor maintenance of protective immunity, necessitating interventions based on factors such as CD4+ T cell counts, B cell response, vaccine formulation, and timing of administration. The initial response to HBV vaccination is crucial for sustaining antibody responses in both infected and uninfected individuals, highlighting the importance of regular follow-up and booster doses to prevent HBV transmission in HIV-1 infected people.
Article
Immunology
Neil Martinson, Bhavna Gordhan, Stefan Petkov, Azure-Dee Pillay, Thabiso Seiphetlo, Natasha Singh, Kennedy Otwombe, Limakatso Lebina, Claudia Fredolini, Francesca Chiodi, Julie Fox, Bavesh Kana, Carolina Herrera
Summary: In this study, researchers compared the mucosal and systemic compartments of vaccinated and unvaccinated individuals in a South African cohort undergoing maxillofacial surgery. They found higher levels of pro-inflammatory proteins in the nasal compartment compared to plasma. The levels of IP-10 and MIG were higher in secretions than in nasal tissue, while the opposite was observed for TGF-beta. The study also identified correlations between nasal anti-SARS-CoV-2 spike IgG and mucosal MIG expression, as well as a positive correlation with IP-10 in BioNTech/Pfizer-vaccinated individuals.
Article
Medicine, Research & Experimental
Yonas Bekele, Tadepally Lakshmikanth, Yang Chen, Jaromir Mikes, Aikaterini Nasi, Stefan Petkov, Bo Hejdeman, Petter Brodin, Francesca Chiodi