Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing

A single-cell molecular map of mouse gastrulation and early organogenesis

(2019) Blanca Pijuan-Sala et al.   NATURE

Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom-Up versus Top-Down

(2019) Kristy Red-Horse et al.   BIOESSAYS

Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors

(2019) Tomomasa Yokomizo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity

(2019) Larsen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells

(2018) Agatheeswaran Subramaniam et al.   HAEMATOLOGICA

Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta

(2018) Chloé S. Baron et al.   Nature Communications

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

(2018) Gene I. Uenishi et al.   Nature Communications

Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential

(2018) Mi Ae Park et al.   Cell Reports

Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells

(2018) Agatheeswaran Subramaniam et al.   HAEMATOLOGICA

HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development

(2018) Nadine Teichweyde et al.   Stem Cell Reports

GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition

(2018) HyunJun Kang et al.   Stem Cell Reports

Arterial identity of hemogenic endothelium: a key to unlock definitive hematopoietic commitment in hPSC cultures

(2018) Igor I. Slukvin et al.   EXPERIMENTAL HEMATOLOGY

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Vascular Endothelial Cadherin and Angiotensin-Converting Enzyme Co-Expression Marks Highly Proliferative Hematopoietic Stem Cells in Human Embryonic Liver

(2018) Yanyan Zhang et al.   STEM CELLS AND DEVELOPMENT

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro

(2018) Eva Garcia-Alegria et al.   Stem Cell Reports

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation

(2017) Alison C. McGarvey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study

(2017) Giorgio Aquila et al.   Journal of Translational Medicine

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

(2017) Raphael Lis et al.   NATURE

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Vascular heterogeneity and specialization in development and disease

(2017) Michael Potente et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

(2017) Jennifer S. Fang et al.   Nature Communications

Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration

(2017) Karolina Komorowska et al.   Cell Reports

Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells

(2016) Carlos-Filipe Pereira et al.   DEVELOPMENTAL CELL

Tracing haematopoietic stem cell formation at single-cell resolution

(2016) Fan Zhou et al.   NATURE

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

(2016) Céline Souilhol et al.   Nature Communications

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

(2015) Xiongwei Cai et al.   Cell Stem Cell

SOX9 modulates the expression of key transcription factors required for heart valve development

(2015) V. C. Garside et al.   DEVELOPMENT

Single-cell resolution of morphological changes in hemogenic endothelium

(2015) Frank L. Bos et al.   DEVELOPMENT

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

(2015) Andrea Ditadi et al.   NATURE CELL BIOLOGY

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

(2015) Roshana Thambyrajah et al.   NATURE CELL BIOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Ribosomal proteins: functions beyond the ribosome

(2015) Xiang Zhou et al.   Journal of Molecular Cell Biology

BMP signalling differentially regulates distinct haematopoietic stem cell types

(2015) Mihaela Crisan et al.   Nature Communications

Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition

(2015) Carlos O. Lizama et al.   Nature Communications

Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

(2015) Bo O Zhou et al.   eLife

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors

(2014) Jonah Riddell et al.   CELL

ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease

(2014) Christopher Lathen et al.   CIRCULATION

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification

(2014) A. C. Wilkinson et al.   DEVELOPMENT

Fgd5identifies hematopoietic stem cells in the murine bone marrow

(2014) Roi Gazit et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells

(2014) Christopher M Sturgeon et al.   NATURE BIOTECHNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development

(2014) S. J. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primitive and definitive erythropoiesis in mammals

(2014) James Palis   Frontiers in Physiology

Identification of the Niche and Phenotype of the First Human Hematopoietic Stem Cells

(2014) Andrejs Ivanovs et al.   Stem Cell Reports

Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature

(2013) X. L. Aranguren et al.   BLOOD

Stat and interferon genes identified by network analysis differentially regulate primitive and definitive erythropoiesis

(2013) Emily Greenfest-Allen et al.   BMC Systems Biology

PDGF Receptor Alpha+ Mesoderm Contributes to Endothelial and Hematopoietic Cells in Mice

(2013) Guo Ding et al.   DEVELOPMENTAL DYNAMICS

Quantitative single-cell RNA-seq with unique molecular identifiers

(2013) Saiful Islam et al.   NATURE METHODS

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

(2013) Gemma Swiers et al.   Nature Communications

Regulation of endothelial and hematopoietic development by the ETS transcription factor Etv2

(2012) Kelly Lammerts van Bueren et al.   CURRENT OPINION IN HEMATOLOGY

EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins

(2012) Zili Lei et al.   DEVELOPMENTAL BIOLOGY

Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells

(2012) B. Mirshekar-Syahkal et al.   HAEMATOLOGICA

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis

(2012) Satoshi Somekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CEL-Seq: Single-Cell RNA-Seq by Multiplexed Linear Amplification

(2012) Tamar Hashimshony et al.   Cell Reports

Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

(2011) Andrejs Ivanovs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

Fibroblast Growth Factor 2 (Fgf2) Inhibits Differentiation of Mesenchymal Stem Cells by Inducing Twist2 and Spry4, Blocking Extracellular Regulated Kinase Activation, and Altering Fgf Receptor Expression Levels

(2011) Wen-Tzu Lai et al.   STEM CELLS

Regulatory gene network circuits underlying T cell development from multipotent progenitors

(2011) Hao Yuan Kueh et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

VE-cadherin expression allows identification of a new class of hematopoietic stem cells within human embryonic liver

(2010) E. Oberlin et al.   BLOOD

Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis

(2010) I. Buschmann et al.   DEVELOPMENT

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

(2010) Monica Corada et al.   DEVELOPMENTAL CELL

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11

(2009) R. K. Hyde et al.   BLOOD

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell