Article
Biochemistry & Molecular Biology
Mojtaba Parvizi, Zachary C. Ryan, Sanam Ebtehaj, Bonnie K. Arendt, Ian R. Lanza
Summary: Research has shown that senescent preadipocytes can induce an inflammatory phenotype, decrease cell viability, disrupt proliferation and migration, affecting the occurrence of vascular diseases by triggering phenotypic and functional changes in key cellular components of blood vessels.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Hematology
Huan Yang, Ting Zhou, Amelia Stranz, Elise DeRoo, Bo Liu
Summary: A study using single-cell RNA sequencing on mouse AAA tissues revealed 12 distinct populations of 8 cell types. The percentages of each population and gene expression were compared between sham and AAA tissue, showing that populations within major cell types such as smooth muscle cells, fibroblasts, and macrophages may contribute differently to AAA pathogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Jahnic Beck-Joseph, Stephanie Lehoux
Summary: This article discusses the pathophysiology of atherosclerosis and the roles of vascular smooth muscle cells and macrophages in the disease. By studying intercellular communication and molecular interactions, a better understanding of the disease and the development of new therapeutic strategies can be achieved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lenka Turner, Paulina J. Stanczyk, Sonja Khemiri, Julie C. Chamberlain, Wei Yang, Tom R. Webb, Christopher P. Nelson, Nilesh J. Samani, Shu Ye
Summary: This comprehensive analysis shows that a large percentage of CAD loci can modulate gene expression in VSMCs and influence VSMC behavior. Several candidate causal genes identified are likely to be druggable and thus represent potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Megumi Miyabe, Nobuhisa Nakamura, Tomokazu Saiki, Satoru Miyabe, Mizuho Ito, Sachiko Sasajima, Tomomi Minato, Tatsuaki Matsubara, Keiko Naruse
Summary: Atherosclerosis is a leading cause of death globally, and there is a correlation between periodontal disease and atherosclerosis. This study used Porphyromonas gingivalis-derived LPS (Pg-LPS) to investigate the proliferation and migration of human aortic smooth muscle cells (HASMCs). The results suggest that Pg-LPS promotes atherosclerosis through the activation of the TLR4-MAPK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Kathleen Zohorsky, Shigang Lin, Kibret Mequanint
Summary: The study demonstrated that utilizing bead-bound Jagged1 was effective in activating Notch3 and promoting SMC differentiation/maturation, while magnetic pulling forces did not activate Notch3 but instead provided necessary clustering or traction forces for Notch activation. The findings suggest that manipulation of Jagged1 presentation strategy can improve biomaterial-driven control of SMC behavior.
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Cansu Karakaya, Mark C. C. van Turnhout, Valery L. L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. M. Sahlgren, Sandra Loerakker
Summary: Mechanical stimuli and Notch signaling play important roles in regulating vascular growth and remodeling. This study reveals that cyclic strain decreases Notch signaling and leads to the loss of contractile features in vascular smooth muscle cells. Activation of Notch signaling partially rescues the contractile features of these cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Francesca Greco, Alessandra Stefania Rizzuto, Marta Zara, Marco Cafora, Chiara Favero, Giulia Solazzo, Ilaria Giusti, Maria Pia Adorni, Francesca Zimetti, Vincenza Dolo, Cristina Banfi, Nicola Ferri, Cesare R. Sirtori, Alberto Corsini, Silvia Stella Barbieri, Anna Pistocchi, Valentina Bollati, Chiara Macchi, Massimiliano Ruscica
Summary: This study reveals that PCSK9 plays an inflammatory role through EVs released by vascular smooth muscle cells, affecting the function and content of neighboring cells, and may have a significant role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jaqueline Herrmann, Mengdi Xia, Manasa Reddy Gummi, Anna Greco, Annika Schacke, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Vessel wall calcification is a structural pathology of aged vessels associated with high cardiovascular mortality in elderly patients. Chronic inflammation and oxidative stress in aging lead to activation of PRRs in vascular cells, contributing to VSMC calcification. Inhibition of PRR activation may be a potential target for reducing vascular calcification and subsequent cardiovascular mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Deborah D. Chin, Christopher Poon, Jonathan Wang, Johan Joo, Victor Ong, Zhangjingyi Jiang, Kayley Cheng, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
Summary: The delivery of miR-145 micelles to VSMCs shows promise in mitigating atherosclerosis progression by altering cell phenotypes and reducing plaque growth. In mouse experiments, miR-145 micelles significantly inhibited the advancement of atherosclerosis.
Review
Developmental Biology
Arndt F. Siekmann
Summary: This review discusses the functions of vascular mural cells in blood vessel formation and diameter regulation, as well as their interactions with endothelial cells. It also introduces the signaling pathways controlling mural cell development and highlights distinguishing features of mural cells located on different types of blood vessels. Therapeutic strategies involving mural cells to improve tissue ischemia and vascular efficiency in various diseases are explored.
Article
Pharmacology & Pharmacy
Randa M. Breikaa, Kimberly Denman, Yukie Ueyama, Patricia E. McCallinhart, Aiman Q. Khan, Gunjan Agarwal, Aaron J. Trask, Vidu Garg, Brenda Lilly
Summary: This study reveals the essential role of Jag1 in adult endothelial cells in regulating and maintaining smooth muscle cell function in arterial vessels, partially through autoregulation of Notch signaling and influencing cell matrix/adhesion components in smooth muscle cells.
VASCULAR PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Susanna L. Lamers, David J. Nolan, Tessa M. LaFleur, Benjamin N. Lain, Samual R. Moot, Christopher R. Huston, Chad D. Neilsen, Amy K. Feehan, Lucio Miele, Rebecca Rose
Summary: This study utilized genomic surveillance to confirm two viral strains infecting offshore workers and suggested that changes in quarantine protocols contributed to outbreaks. The findings support that industrial hygiene quarantine/testing protocols limited viral transmissions, halted offshore outbreaks, and prevented the spread of a variant of interest.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Nutrition & Dietetics
Luisa Marracino, Angela Punzo, Paolo Severi, Rosane Nganwouo Tchoutang, Celia Vargas-De-la-Cruz, Francesca Fortini, Francesco Vieceli Dalla Sega, Alessia Silla, Emanuele Porru, Patrizia Simoni, Valentina Rosta, Alessandro Trentini, Achille Wilfred Ouambo Talla, Silvana Hrelia, Carlo Cervellati, Paola Rizzo, Cristiana Caliceti
Summary: The study investigates the effects of fermentation with Lactiplantibacillus plantarum on the antioxidant and immunomodulatory properties of Pushgay berries. The results show that fermentation enhances the antioxidant activity and immunomodulatory effects of the berries.
Review
Cardiac & Cardiovascular Systems
Marco Bruno Morelli, Chiara Bongiovanni, Silvia Da Pra, Carmen Miano, Francesca Sacchi, Mattia Lauriola, Gabriele D'Uva
Summary: Chemotherapy and targeted therapies can cause cardiotoxicity, leading to cardiac dysfunction and affecting survival and quality of life. Cardiotoxicity can be reversible or irreversible, and there is a need for cardioprotective therapies to reduce its occurrence and progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Francesco Vieceli Dalla Sega, Francesca Fortini, Paolo Severi, Paola Rizzo, Iija Gardi, Paolo Cimaglia, Claudio Rapezzi, Luigi Tavazzi, Roberto Ferrari
Summary: This review discusses the pathogenesis and therapeutic approaches of vascular and heart calcifications in different conditions. Calcifications are complex disorders that have significant implications for cardiovascular and kidney diseases.
Letter
Medicine, General & Internal
Edoardo Gronda, Massimo Iacoviello, Domenico Gabrielli, Pasquale Caldarola, Luigi Tavazzi, CArdiac REnal MEtab CARE ME Sci Area, Assoc Nazl Med Cardiol Osped ANMCO
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Cristiana Caliceti, Angela Punzo, Alessia Silla, Patrizia Simoni, Giulia Roda, Silvana Hrelia
Summary: Colorectal cancer ranks second among tumor deaths worldwide, and early diagnosis is crucial for successful treatment. A high-fat diet promotes the synthesis of bile acids, which is correlated with colorectal cancer incidence.
Article
Cardiac & Cardiovascular Systems
Andrea Saglietto, Fiorenzo Gaita, Carina Blomstrom-Lundqvist, Elena Arbelo, Nikolaos Dagres, Josep Brugada, Aldo Pietro Maggioni, Luigi Tavazzi, Josef Kautzner, Gaetano Maria De Ferrari, Matteo Anselmino
Summary: This study aimed to develop a machine-learning scoring system based on easily accessible clinical variables from the ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry to predict the probability of 1-year arrhythmic recurrence after catheter ablation for AF patients. Among four different supervised machine-learning models, the random forest model achieved the best performance with a 19-variable version, outperforming existing scores. The final calibrated model, available as a web calculator, showed significantly better predictive performance.
Article
Biochemistry & Molecular Biology
Francesco Vieceli Dalla Sega, Paolo Cimaglia, Marco Manfrini, Francesca Fortini, Luisa Marracino, Davide Bernucci, Graziella Pompei, Antonella Scala, Michele Trichilo, Beatrice De Carolis, Luca Dalla Paola, Roberto Ferrari, Paola Rizzo, Gianluca Campo
Summary: This study aimed to identify potential biomarkers that predict the disease course in diabetic patients with critical limb ischemia (CLI). The circulating levels of 23 molecules related to inflammation, endothelial dysfunction, platelet activation, and thrombophilia were measured in 92 patients. The study found that certain biomarkers were associated with DFU healing, the need for new revascularization, and the appearance of new lesions or relapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Cristiana Caliceti, Marco Malaguti, Luisa Marracino, Maria Cristina Barbalace, Paola Rizzo, Silvana Hrelia
Summary: This article summarizes the potential use of waste or by-products derived from the processing of traditional Italian crops (apple, pear, and sugar beet) as a source of bioactive molecules to protect endothelial function. The waste matrices of these crops have the potential to be used as starting materials for producing upcycled products with functional applications, such as the prevention of endothelial dysfunction associated with cardiovascular diseases.
Editorial Material
Cardiac & Cardiovascular Systems
Claudio Rapezzi, Alberto Aimo, Iacopo Fabiani, Vincenzo Castiglione, Roberto Ferrari, Aldo Pietro Maggioni, Luigi Tavazzi
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Alessia Silla, Federica Fogacci, Angela Punzo, Silvana Hrelia, Patrizia Simoni, Cristiana Caliceti, Arrigo F. G. Cicero
Summary: Atherosclerosis and ASCVD can be improved by reducing the levels of LDL cholesterol. A new injectable antibody targeting PCSK9, called Evolocumab, has been approved for better lipid control in high-risk individuals. The use of Evolocumab has shown significant improvement in blood pressure and arterial pulse wave velocity, as well as a decrease in H2O2 production.
Article
Oncology
Michele Vigolo, Charlotte Urech, Sebastien Lamy, Giulia Monticone, Jovanny Zabaleta, Fokhrul Hossain, Dorota Wyczechowska, Luis Del Valle, Ruth M. O'Regan, Lucio Miele, Rajwinder Lehal, Samarpan Majumder
Summary: Notch signaling is involved in treatment resistance and cancer stem cell maintenance in breast cancer. CB-103 is a novel pan-Notch inhibitor with improved safety and efficacy compared to first-generation inhibitors. The study demonstrates that CB-103 in combination with fulvestrant or paclitaxel exhibits promising therapeutic potential in endocrine-resistant and triple negative breast cancers.