MOTS‐c: A Mitochondrial‐Encoded Regulator of the Nucleus

Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment

(2019) Farasat Zaman et al.   FASEB JOURNAL

Unraveling the hidden universe of small proteins in bacterial genomes

(2019) Samuel Miravet‐Verde et al.   Molecular Systems Biology

MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction

(2019) Huanyu Lu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ethics of Human Genome Editing

(2019) Barry S. Coller   Annual Review of Medicine

Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c

(2019) Qingyang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome

(2019) Ruud P. H. Raijmakers et al.   Journal of Translational Medicine

Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects

(2019) Manjunath Ramanjaneya et al.   Frontiers in Endocrinology

Mitochondrial peptides modulate mitochondrial function during cellular senescence

(2018) Su-Jeong Kim et al.   Aging-US

Humanin Analogue (HNG) Enhances the Protective Effect of Dexrazoxane against Doxorubicin-induced Cardiotoxicity

(2018) YanHe Lue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Chronic Treatment With the Mitochondrial Peptide Humanin Prevents Age-related Myocardial Fibrosis in mice

(2018) Qing Qin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells

(2018) Qingqing Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cross-site comparison of ribosomal depletion kits for Illumina RNAseq library construction

(2018) Zachary T. Herbert et al.   BMC GENOMICS

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

(2018) Kyung Hwa Kim et al.   Cell Metabolism

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer

(2018) Lisa M Lindqvist et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction

(2018) Qing Qin et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury

(2018) Sirinart Kumfu et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals

(2018) Luis Rodrigo Cataldo et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity

(2018) Savitree Thummasorn et al.   MITOCHONDRION

Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance

(2018) Caiqi Du et al.   PEDIATRIC DIABETES

Short Open Reading Frames and Their Encoded Peptides

(2018) Joseph Rothnagel et al.   PROTEOMICS

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized

(2018) Payam A. Gammage et al.   TRENDS IN GENETICS

Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin

(2018) Natividad Blasco et al.   Redox Biology

Role of Signaling Molecules in Mitochondrial Stress Response

(2018) Shauna Hill et al.   Frontiers in Genetics

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy

(2018) Meagan J. McManus et al.   Cell Metabolism

A Mitochondrial-Derived Peptide Exercises the Nuclear Option

(2018) Kailash C. Mangalhara et al.   Cell Metabolism

Deep mitochondrial origin outside the sampled alphaproteobacteria

(2018) Joran Martijn et al.   NATURE

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

(2018) Sandra R. Bacman et al.   NATURE MEDICINE

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

(2018) Payam A. Gammage et al.   NATURE MEDICINE

Going nuclear with stress

(2018) Wei Wong   Science Signaling

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans

(2018) Kelvin Yen et al.   Scientific Reports

A Mitochondrial Encoded Messenger at the Nucleus

(2018) Cheryl Yong et al.   Cells

Small, but mighty? Searching for human microproteins and their potential for understanding health and disease

(2018) Annie Rathore et al.   Expert Review of Proteomics

Development of a mass spectrometry-based detection method for the mitochondrion-derived peptide MOTS-c in plasma samples for doping control purposes

(2018) A. Knoop et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Investigating mitonuclear interactions in human admixed populations

(2018) Arslan A. Zaidi et al.   Nature Ecology & Evolution

The mitochondrial unfolded protein response: Signaling from the powerhouse

(2017) Mohammed A. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse

(2017) Kun Han et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrially derived peptides as novel regulators of metabolism

(2017) Su-Jeong Kim et al.   JOURNAL OF PHYSIOLOGY-LONDON

MOTS-c peptide increases survival and decreases bacterial load in mice infected with MRSA

(2017) Dongsheng Zhai et al.   MOLECULAR IMMUNOLOGY

Classification and function of small open reading frames

(2017) Juan-Pablo Couso et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells

(2017) Leonid Minasyan et al.   Oxidative Medicine and Cellular Longevity

Mining for Micropeptides

(2017) Catherine A. Makarewich et al.   TRENDS IN CELL BIOLOGY

Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage

(2017) Sonali Nashine et al.   Cell Death & Disease

Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration

(2017) Heather M. Wilkins et al.   Frontiers in Immunology

Integrative Approaches for Studying Mitochondrial and Nuclear Genome Co-evolution in Oxidative Phosphorylation

(2017) Paul Sunnucks et al.   Frontiers in Genetics

The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity

(2017) Alan K. Okada et al.   Scientific Reports

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers

(2016) Laura J. Cobb et al.   Aging-US

Enjoy the Trip: Calcium in Mitochondria Back and Forth

(2016) Diego De Stefani et al.   Annual Review of Biochemistry

Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation

(2016) Wei Ming et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier

(2016) Hong Ma et al.   Cell Metabolism

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Intracellular mitochondrial DNA transfers to the nucleus in human cancer cells

(2016) Young Seok Ju   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila

(2016) J. A. Mossman et al.   GENETICS

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?

(2016) Troy L. Merry et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Mitochondria in the second act

(2016) Thijs J. G. Ettema   NATURE

Synchronized mitochondrial and cytosolic translation programs

(2016) Mary T. Couvillion et al.   NATURE

Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry

(2016) Alexandros A. Pittis et al.   NATURE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione

(2016) Douglas Matsunaga et al.   PLoS One

Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs

(2016) Mario Thevis et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis

(2016) Ulrike Topf et al.   TRENDS IN CELL BIOLOGY

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus

(2016) Su-Jeong Kim et al.   Oncotarget

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

(2015) Noriyuki Fuku et al.   AGING CELL

Mitochondria: The Cellular Hub of the Dynamic Coordinated Network

(2015) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

A Mitochondrially Encoded Hormone Ameliorates Obesity and Insulin Resistance

(2015) Kim Zarse et al.   Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

Risks inherent to mitochondrial replacement

(2015) E. H. Morrow et al.   EMBO REPORTS

Mitonuclear Ecology

(2015) Geoffrey E. Hill   MOLECULAR BIOLOGY AND EVOLUTION

Complex archaea that bridge the gap between prokaryotes and eukaryotes

(2015) Anja Spang et al.   NATURE

Discovery and characterization of smORF-encoded bioactive polypeptides

(2015) Alan Saghatelian et al.   Nature Chemical Biology

Protein acetylation in metabolism — metabolites and cofactors

(2015) Keir J. Menzies et al.   Nature Reviews Endocrinology

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes

(2015) Fernanda Marques da Cunha et al.   Oxidative Medicine and Cellular Longevity

Why chloroplasts and mitochondria retain their own genomes and genetic systems: Colocation for redox regulation of gene expression

(2015) John F. Allen   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitonuclear linkage disequilibrium in human populations

(2015) Daniel B. Sloan et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mutations causing mitochondrial disease: What is new and what challenges remain?

(2015) R. N. Lightowlers et al.   SCIENCE

Mitochondrial-nuclear DNA mismatch matters

(2015) K. J. Dunham-Snary et al.   SCIENCE

Eggs' power plants energize new IVF debate

(2015) J. Couzin-Frankel   SCIENCE

Mitochondrial Proteins Moonlighting in the Nucleus

(2015) Richard M. Monaghan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Compatibility between mitochondrial and nuclear genomes correlates with the quantitative trait of lifespan in Caenorhabditis elegans

(2015) Zuobin Zhu et al.   Scientific Reports

Mitochondrial–Nuclear Epistasis Impacts Fitness and Mitochondrial Physiology of Interpopulation Caenorhabditis briggsae Hybrids

(2015) Chih-Chiun Chang et al.   G3-Genes Genomes Genetics

IGF-I regulates the age-dependent signaling peptide humanin

(2014) Changhan Lee et al.   AGING CELL

Mitochondrial–nuclear genome interactions in non-alcoholic fatty liver disease in mice

(2014) Angela M. Betancourt et al.   BIOCHEMICAL JOURNAL

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Use of stereotypical mutational motifs to define resolution limits for the ultra-deep resequencing of mitochondrial DNA

(2014) Kristian Gardner et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Transcription Factors Bind Negatively Selected Sites within Human mtDNA Genes

(2014) Amit Blumberg et al.   Genome Biology and Evolution

Protective Role of Humanin on Bortezomib-Induced Bone Growth Impairment in Anticancer Treatment

(2014) Emma Eriksson et al.   JNCI-Journal of the National Cancer Institute

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Evidence for Site-Specific Occupancy of the Mitochondrial Genome by Nuclear Transcription Factors

(2014) Georgi K. Marinov et al.   PLoS One

Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling

(2014) C. C. Williams et al.   SCIENCE

OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria

(2014) Chen Lesnik et al.   Nature Communications

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

(2014) Laura C. Greaves et al.   PLoS Genetics

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle

(2013) Ehab H. Sarsour et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload

(2013) Jessica L. Fetterman et al.   BIOCHEMICAL JOURNAL

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases

(2013) M. Cristina Kenney et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aging: Seeking Mitonuclear Balance

(2013) Jason Karpac et al.   CELL

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Mitochondrial Regulation in Pluripotent Stem Cells

(2013) Xiuling Xu et al.   Cell Metabolism

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Replacement, Evolution, and the Clinic

(2013) K. Reinhardt et al.   SCIENCE

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

(2013) Scott R. Kennedy et al.   PLoS Genetics

De Novo ORFs in Drosophila Are Important to Organismal Fitness and Evolved Rapidly from Previously Non-coding Sequences

(2013) Josephine A. Reinhardt et al.   PLoS Genetics

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila

(2013) Colin D. Meiklejohn et al.   PLoS Genetics

A positive role for yeast extrachromosomal rDNA circles?

(2012) Anthony M. Poole et al.   BIOESSAYS

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice

(2012) Xin Zhang et al.   LIFE SCIENCES

Bacteriocins — a viable alternative to antibiotics?

(2012) Paul D. Cotter et al.   NATURE REVIEWS MICROBIOLOGY

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Humanin, a Cytoprotective Peptide, Is Expressed in Carotid Artherosclerotic Plaques in Humans

(2012) David G. Zacharias et al.   PLoS One

Correlative 3D superresolution fluorescence and electron microscopy reveal the relationship of mitochondrial nucleoids to membranes

(2012) B. G. Kopek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Mitochondrial tRNA Import and Its Consequences for Mitochondrial Translation

(2011) André Schneider   Annual Review of Biochemistry

Mitochondrial Regulation of Cell Cycle and Proliferation

(2011) Valeria Gabriela Antico Arciuch et al.   ANTIOXIDANTS & REDOX SIGNALING

Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice

(2011) Yun K. Oh et al.   ATHEROSCLEROSIS

Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations

(2011) Nick Lane   BIOESSAYS

Mitochondrial Stress Signals Revise an Old Aging Theory

(2011) Dong Kyun Woo et al.   CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

The Human Mitochondrial Transcriptome

(2011) Tim R. Mercer et al.   CELL

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Hundreds of putatively functional small open reading frames in Drosophila

(2011) Emmanuel Ladoukakis et al.   GENOME BIOLOGY

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Epigenetic Control of Aging

(2010) Ursula Muñoz-Najar et al.   ANTIOXIDANTS & REDOX SIGNALING

Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress

(2010) A. R. Bachar et al.   CARDIOVASCULAR RESEARCH

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

ChIP-PaM: an algorithm to identify protein-DNA interaction using ChIP-Seq data

(2010) Song Wu et al.   Theoretical Biology and Medical Modelling

Humanin: A Novel Central Regulator of Peripheral Insulin Action

(2009) Radhika H. Muzumdar et al.   PLoS One

Incompatibility of Nuclear and Mitochondrial Genomes Causes Hybrid Sterility between Two Yeast Species

(2008) Hsin-Yi Lee et al.   CELL

Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

(2008) Ozlem Keskin et al.   CHEMICAL REVIEWS

Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunction

(2008) Nicholas D. Bonawitz et al.   CURRENT GENETICS

Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import

(2008) M. A. T. Rubio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA