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SPARTA: Simple Program for Automated reference-based bacterial RNA-seq Transcriptome Analysis

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The DosR Regulon Modulates Adaptive Immunity and Is Essential forMycobacterium tuberculosisPersistence

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DosS Is Required for the Complete Virulence ofMycobacterium tuberculosisin Mice with Classical Granulomatous Lesions

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The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence

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Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

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Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

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Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

(2014) Jan Rybniker et al.   Cell Host & Microbe

Slow growth ofMycobacterium tuberculosisat acidic pH is regulated byphoPRand host-associated carbon sources

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The Mycobacterium tuberculosis regulatory network and hypoxia

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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

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Small-Molecule Inhibitors of toxT Expression in Vibrio cholerae

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Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell

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A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

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NIH Image to ImageJ: 25 years of image analysis

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Broad Spectrum Pro-Quorum-Sensing Molecules as Inhibitors of Virulence in Vibrios

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Ultrafast Ligand Dynamics in the Heme-Based GAF Sensor Domains of the Histidine Kinases DosS and DosT from Mycobacterium tuberculosis

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Blockage of the channel to heme by the E87 side chain in the GAF domain ofMycobacterium tuberculosisDosS confers the unique sensitivity of DosS to oxygen

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Design, Synthesis, and Study of a Mycobactin−Artemisinin Conjugate That Has Selective and Potent Activity against Tuberculosis and Malaria

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aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome

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Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity

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Different Roles of DosS and DosT in the Hypoxic Adaptation of Mycobacteria

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Anti-virulence strategies to combat bacteria-mediated disease

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Mycobacterium tuberculosis Transcriptional Adaptation, Growth Arrest and Dormancy Phenotype Development Is Triggered by Vitamin C

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DevS Oxy Complex Stability Identifies This Heme Protein as a Gas Sensor inMycobacterium tuberculosisDormancy

(2009) Alexandra Ioanoviciu et al.   BIOCHEMISTRY

Unique Roles of DosT and DosS in DosR Regulon Induction and Mycobacterium tuberculosis Dormancy

(2009) R. W. Honaker et al.   INFECTION AND IMMUNITY

The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy

(2009) R. L. Leistikow et al.   JOURNAL OF BACTERIOLOGY

Structural Insight into the Heme-based Redox Sensing by DosS fromMycobacterium tuberculosis

(2009) Ha Yeon Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Design of DevR Inhibitor Active against NonreplicatingMycobacterium tuberculosis

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A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen

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2.3 Å X-ray Structure of the Heme-Bound GAF Domain of Sensory Histidine Kinase DosT ofMycobacterium tuberculosis†‡

(2008) Larissa M. Podust et al.   BIOCHEMISTRY

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

(2008) Shiming Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Role of the dosR-dosS Two-Component Regulatory System in Mycobacterium tuberculosis Virulence in Three Animal Models

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Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis

(2008) Anil Koul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting QseC Signaling and Virulence for Antibiotic Development

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Artemisinins: their growing importance in medicine

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