Promising Directions in Atherosclerosis Treatment Based on Epigenetic Regulation Using MicroRNAs and Long Noncoding RNAs

Hematopoietic Deficiency of the Long Non-Coding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation

(2019) Sebastian Cremer et al.   CIRCULATION

The lncRNA CHROME regulates cholesterol homeostasis

(2019) Alexandra Le Bras   Nature Reviews Cardiology

How Might Bromodomain and Extra-Terminal (BET) Inhibitors Operate in Cardiovascular Disease?

(2019) C. Mary Schooling et al.   American Journal of Cardiovascular Drugs

Cellular functions of long noncoding RNAs

(2019) Run-Wen Yao et al.   NATURE CELL BIOLOGY

Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122

(2018) Fang-Ni Chai et al.   BIOMEDICINE & PHARMACOTHERAPY

TET2: A Novel Epigenetic Regulator and Potential Intervention Target for Atherosclerosis

(2018) Yami Liu et al.   DNA AND CELL BIOLOGY

Long Non-Coding RNA Malat1 Regulates Angiogenesis in Hindlimb Ischemia

(2018) Xuejing Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

(2018) Xingli Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell‑specific histone modifications in atherosclerosis (Review)

(2018) Wanlin Jiang et al.   Molecular Medicine Reports

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

(2018) Tamer Sallam et al.   NATURE MEDICINE

Epigenetic drug discovery: a success story for cofactor interference

(2018) A. Ganesan   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA

(2018) H. S. Jeffrey Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atherosclerosis Is an Epigenetic Disease

(2018) Suowen Xu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Non-coding RNA regulation of endothelial and macrophage functions during atherosclerosis

(2018) Binod Aryal et al.   VASCULAR PHARMACOLOGY

Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function

(2018) Yifei Miao et al.   Nature Communications

Epigenome-wide association study of metabolic syndrome in African-American adults

(2018) Tomi Akinyemiju et al.   Clinical Epigenetics

Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions

(2018) Yu-Long Wang et al.   PeerJ

Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE−/−mice

(2018) Martina Gast et al.   CARDIOVASCULAR RESEARCH

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease

(2018) Eithne M. Maguire et al.   VASCULAR PHARMACOLOGY

Potential epigenetic therapeutics for atherosclerosis treatment

(2018) Ioana Nicorescu et al.   ATHEROSCLEROSIS

DNA methylation processes in atheosclerotic plaque

(2018) Einari Aavik et al.   ATHEROSCLEROSIS

Atherogenic index of plasma is a novel predictor of non-alcoholic fatty liver disease in obese participants: a cross-sectional study

(2018) Qian WANG et al.   Lipids in Health and Disease

Non-HDL-cholesterol and apolipoprotein B compared with LDL-cholesterol in atherosclerotic cardiovascular disease risk assessment

(2018) Stuart S. Carr et al.   PATHOLOGY

Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease

(2018) A.David Marais   PATHOLOGY

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

(2018) Suowen Xu et al.   PHARMACOLOGY & THERAPEUTICS

SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4

(2018) Qing Lyu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Non-coding RNA in Vascular Biology and Disease

(2018) John Hung et al.   Frontiers in Physiology

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

Treatment of cardiovascular pathology with epigenetically active agents: Focus on natural and synthetic inhibitors of DNA methylation and histone deacetylation

(2017) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Development of Novel Therapeutic Agents by Inhibition of Oncogenic MicroRNAs

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

(2017) Yang W. Zhang et al.   MOLECULAR CELL

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

(2017) Takao Fujisawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

(2017) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systems biology analysis of longitudinal functional response of endothelial cells to shear stress

(2017) Nassim E. Ajami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas9-mediated noncoding RNA editing in human cancers

(2017) Jie Yang et al.   RNA Biology

Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins

(2017) Abhishek K. Singh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods

(2017) Nadiya Khyzha et al.   TRENDS IN MOLECULAR MEDICINE

PCSK9 as a therapeutic target for cardiovascular disease

(2017) Pei-Ying Zhang   Experimental and Therapeutic Medicine

Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells

(2017) Annette E Neele et al.   Epigenomics

LncRNA MALAT1 regulates smooth muscle cell phenotype switch via activation of autophagy

(2017) Tie-Feng Song et al.   Oncotarget

An emerging function of circRNA-miRNAs-mRNA axis in human diseases

(2017) Dawei Rong et al.   Oncotarget

Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis

(2017) Nathan L. Price et al.   Cell Reports

DNA Hypomethylating Drugs in Cancer Therapy

(2017) Takahiro Sato et al.   Cold Spring Harbor Perspectives in Medicine

Cardiovascular Disease and Long Noncoding RNAs

(2017) Elizabeth J. Hennessy   Circulation-Cardiovascular Genetics

How do lncRNAs regulate transcription?

(2017) Yicheng Long et al.   Science Advances

Transcriptional regulation of the human Liver X Receptor α gene by Hepatocyte Nuclear Factor 4α

(2016) Dimitris Theofilatos et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RISC assembly: Coordination between small RNAs and Argonaute proteins

(2016) Hotaka Kobayashi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies

(2016) Karel Ulbrich et al.   CHEMICAL REVIEWS

Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization

(2016) Margreet R. de Vries et al.   CURRENT OPINION IN LIPIDOLOGY

Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes

(2016) Peter Willeit et al.   DIABETES

Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?

(2016) Peter Willeit et al.   EUROPEAN HEART JOURNAL

The role of epigenetic modifications in cardiovascular disease: A systematic review

(2016) Taulant Muka et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Improving power and accuracy of genome-wide association studies via a multi-locus mixed linear model methodology

(2016) Shi-Bo Wang et al.   Scientific Reports

DNMT1-PPARγ pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice

(2016) Jie Yu et al.   Scientific Reports

Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of the Phase 2b, Randomized, Double-Blind, Multicenter, ASSURE Trial

(2015) Stephen J. Nicholls et al.   American Journal of Cardiovascular Drugs

A Liver-Enriched Long Non-Coding RNA, lncLSTR, Regulates Systemic Lipid Metabolism in Mice

(2015) Ping Li et al.   Cell Metabolism

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in AtherosclerosisNovelty and Significance

(2015) Denuja Karunakaran et al.   CIRCULATION RESEARCH

LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes

(2015) Megan V. Cannon et al.   DIABETOLOGIA

Nanopharmaceuticals (part 2): products in the pipeline

(2015) Volkmar Weissig et al.   International Journal of Nanomedicine

Detection of atherosclerotic lesions and intimal macrophages using CD36-targeted nanovesicles

(2015) Shufang Nie et al.   JOURNAL OF CONTROLLED RELEASE

Endothelium-enriched microRNAs as diagnostic biomarkers for cardiac allograft vasculopathy

(2015) Neha Singh et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

(2015) Leigh Goedeke et al.   NATURE MEDICINE

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

(2015) Alexandre Wagschal et al.   NATURE MEDICINE

Alternation of histone and DNA methylation in human atherosclerotic carotid plaques

(2015) Rudolf Napieralski et al.   THROMBOSIS AND HAEMOSTASIS

siRNA Versus miRNA as Therapeutics for Gene Silencing

(2015) Jenny K W Lam et al.   Molecular Therapy-Nucleic Acids

The complexity of miRNA-mediated repression

(2014) A Wilczynska et al.   CELL DEATH AND DIFFERENTIATION

LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity

(2014) Gengze Wu et al.   CIRCULATION

Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth

(2014) Katharina M. Michalik et al.   CIRCULATION RESEARCH

DNA Methylation Map of Human Atherosclerosis

(2014) S. Zaina et al.   Circulation-Cardiovascular Genetics

MicroRNAs as therapeutic targets in atherosclerosis

(2014) Xavier Loyer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents

(2014) Volker Baumann et al.   Future Medicinal Chemistry

The ways of action of long non-coding RNAs in cytoplasm and nucleus

(2014) Kun Zhang et al.   GENE

Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance

(2014) Rémy Denzler et al.   MOLECULAR CELL

Big pharma shows signs of renewed interest in RNAi drugs

(2014) Nicholette Zeliadt   NATURE MEDICINE

Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines

(2014) Tsui-Ting Ho et al.   NUCLEIC ACIDS RESEARCH

Functional interactions among microRNAs and long noncoding RNAs

(2014) Je-Hyun Yoon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series)

(2014) Joseph Loscalzo et al.   Pulmonary Circulation

Potential of resveratrol in the treatment of heart failure

(2013) Pema Raj et al.   LIFE SCIENCES

MicroRNA 33 Regulates Glucose Metabolism

(2013) C. M. Ramirez et al.   MOLECULAR AND CELLULAR BIOLOGY

siRNA-based nanomedicine

(2013) Jing Zhao et al.   Nanomedicine

MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion

(2013) James Soh et al.   NATURE MEDICINE

On the classification of long non-coding RNAs

(2013) Lina Ma et al.   RNA Biology

Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis

(2013) Y K Adlakha et al.   Cell Death & Disease

The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation

(2013) Felipe C. Beckedorff et al.   PLoS Genetics

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

(2013) Lesca M. Holdt et al.   PLoS Genetics

Discovering the first microRNA-targeted drug

(2012) Morten Lindow et al.   JOURNAL OF CELL BIOLOGY

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

(2012) Ryszard Kole et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B

(2011) Ada Congrains et al.   ATHEROSCLEROSIS

Angiotensin II Infusion–Induced Inflammation, Monocytic Fibroblast Precursor Infiltration, and Cardiac Fibrosis are Pressure Dependent

(2011) Guanming Qi et al.   Cardiovascular Toxicology

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

Cancer therapy via modulation of micro RNA levels: a promising future

(2010) Satya K. Kota et al.   DRUG DISCOVERY TODAY

MicroRNAs as biomarkers in rheumatic diseases

(2010) Ilias Alevizos et al.   Nature Reviews Rheumatology

MicroRNA sponges: Progress and possibilities

(2010) M. S. Ebert et al.   RNA

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors

(2009) Takayoshi Suzuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Obesity, inflammation, and atherosclerosis

(2009) Viviane Z. Rocha et al.   Nature Reviews Cardiology

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

RNAi mechanisms and applications

(2008) Daniel H. Kim et al.   BIOTECHNIQUES

Targeted Delivery of Small Interfering RNA: Approaching Effective Cancer Therapies

(2008) K. F. Pirollo et al.   CANCER RESEARCH

Deadenylation is a widespread effect of miRNA regulation

(2008) A. Eulalio et al.   RNA