Article
Biochemistry & Molecular Biology
Kai Shi, Yingling Lu, Xiaolu Chen, Dongfeng Li, Wenxing Du, Minli Yu
Summary: Tet2 plays a crucial role in chicken myogenesis by regulating the demethylation of genomic DNA and histones to control the expression of MRFs, thus contributing to myoblast differentiation. The expression of Tet2 is significantly elevated during myoblast differentiation, leading to an increase in 5hmC levels and a decrease in H3K9me2 and H3K27me3 levels. Knockdown of Tet2 inhibits the formation of multinucleated myotubes and reduces pivotal MRFs expression.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Review
Oncology
Lina Hu, Xuanye Zhang, Huifeng Li, Suxia Lin, Shengbing Zang
Summary: Recent advances in exome sequencing and comprehensive genomic studies have provided new insights into the pathogenesis and mutational landscape of Angioimmunoblastic T-cell lymphoma (AITL). The discovery of recurrent mutations in TET2, DNMT3A, IDH2, and RHOA has highlighted their essential role in AITL. Furthermore, the detection of TET2 mutations in bystander B cells in AITL samples has advanced our understanding of the disease's mechanisms and its association with B-cell lymphoma.
Article
Biochemistry & Molecular Biology
Yinglin Lu, Kai Shi, Haobin Wang, Heng Cao, Fan Li, Jing Zhou, Minli Yu, Debing Yu
Summary: Ascorbic acid and 5-AZA promote myogenic differentiation by regulating DNA demethylation and histone modification levels, with Tet2 playing a key role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Boyi Cong, Qian Zhang, Xuetao Cao
Summary: TET2, a crucial regulator in hematopoiesis, is involved in the development of hematological malignancies. Recent studies have shown its important role in innate immune homeostasis and inflammation resolution. Understanding the functions and regulation of TET2 can provide insights for intervention in pathological processes caused by TET2 dysregulation.
Article
Cardiac & Cardiovascular Systems
Maria A. Zuriaga, Jose J. Fuster
Summary: Accumulating evidence suggests that conventional cardiovascular risk factors are incomplete predictors of cardiovascular disease, as a substantial risk remains even when these factors are well-managed. Clonal hematopoiesis has emerged as a new and potent risk factor for atherosclerotic cardiovascular disease and other cardiometabolic conditions. However, the understanding of the epidemiology, biology, and clinical implications of this phenomenon remains incomplete.
CIRCULATION JOURNAL
(2023)
Article
Multidisciplinary Sciences
Andrew Baessler, Camille L. Novis, Zuolian Shen, Jelena Perovanovic, Mark Wadsworth, Kendall A. Thiede, Linda M. Sircy, Malia Harrison-Chau, Nguyen X. Nguyen, Katherine E. Varley, Dean Tantin, J. Scott Hale
Summary: Following viral infection, Tet2-deficient CD4(+) T cells exhibit a preference for differentiating into highly functional germinal center T follicular helper (T-FH) cells. Tet2 coordinates with multiple transcription factors to regulate the demethylation and expression of target genes, including those that inhibit T-FH differentiation.
Article
Biochemistry & Molecular Biology
Lan Luo, Rui Li, Guiping Wang, Jingsi Chen, Liangkai Chen, Li-Qiang Qin, Zengli Yu, Zhongxiao Wan
Summary: The study found that a combination of a high fat diet and an advanced glycation end products diet induced worse cognitive impairment in middle-aged mice compared to just a high fat diet, and voluntary exercise improved cognitive function after the combined diet. In young mice, the neuro-protective effects of exercise were associated with inhibiting certain genes and promoting a balanced gut microbiota, while in middle-aged mice, exercise improved cognitive function by adjusting protein expression and restoring intestinal permeability.
Article
Oncology
Xinchao Zhang, Shuyan Li, Jing He, Yunjie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou, Yixin Xu, Qun-Ying Lei, Jing Zhang, Qing Zhang, Yanping Xu, Lei Lv
Summary: The study reveals a unique role of TET2 in suppressing tumor metabolism and HIF signaling in ccRCC, providing therapeutic targets, potential drugs, and prognostic markers for the management of the disease.
Article
Immunology
Zheng-jun Gao, Wen-ping Li, Xin-tao Mao, Tao Huang, Hao-li Wang, Yi-ning Li, Bao-qin Liu, Jiang-yan Zhong, Chai Renjie, Jin Jin, Yi-yuan Li
Summary: This study reveals that deficiency of Uhrf1 in myeloid cells significantly upregulates Ifnb expression, enhancing resistance to viral infection. Whole-genome bisulfite sequencing identified a single nucleotide methylation site in the Ifnb promoter region that disrupts IRF3 recruitment. Further experiments confirmed the critical role of this methylated site in regulating Ifnb expression and antiviral responses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Environmental Sciences
Zhe Li, Yun Ren, Xuan Li, Wenwen Wang
Summary: BPA and BPS, recognized endocrine disruptors, target estrogen receptors and contribute to the development of breast cancer. This study reveals the interplay between KDM2A-mediated histone demethylation and ER-dependent estrogen activity, as well as their involvement in TET2-catalyzed DNA hydroxymethylation, in the proliferation of ER+ breast cancer cells induced by BPA/BPS.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell & Tissue Engineering
Hector Huerga Encabo, Iker Valle Aramburu, Manuel Garcia-Albornoz, Marion Piganeau, Henry Wood, Anna Song, Alessandra Ferrelli, Aneesh Sharma, Carlos M. Minutti, Marie-Charlotte Domart, Despoina Papazoglou, Kristian Gurashi, Miriam Llorian Sopena, Robert Goldstone, Todd Fallesen, Qian Wang, Linda Ariza-McNaughton, Daniel H. Wiseman, Kiran Batta, Rajeev Gupta, Venizelos Papayannopoulos, Dominique Bonnet
Summary: Somatic mutations in hematopoietic stem cells (HSCs) can lead to clonal hematopoiesis (CH) and the production of mutated immune cells, increasing the risk of leukemia and inflammatory diseases. Through genetic engineering and transplantation, researchers found that loss of the TET2 gene in human HSCs resulted in abnormal development and function of neutrophils, leading to heightened inflammatory responses and compact chromatin structure. These findings provide insights into detecting TET2-CH and preventing CH-associated pathologies mediated by neutrophil extracellular traps (NET).
Review
Biochemistry & Molecular Biology
Ashikh Seethy, Karthikeyan Pethusamy, Indranil Chattopadhyay, Ramkishor Sah, Anita Chopra, Ruby Dhar, Subhradip Karmakar
Summary: The article explores the role of cytosine methylation and TET proteins in DNA modification, highlighting the significance of TET2 in hematological disorders and non-hematological malignancies. It emphasizes the importance of TET2 in both epigenetics and epitranscriptomics, showcasing its versatile functions and associations with various diseases.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Oncology
Feng Wan, Yue-Wen Tang, Xuan-Li Tang, Ya-Yu Li, Ru-Chun Yang
Summary: The study revealed that triptolide can reverse podocyte EMT process and increase TET2 expression, protecting podocytes from injury and reducing proteinuria. Furthermore, triptolide may exert its protective effect on podocytes by regulating DNA demethylation, particularly at the promoters of NEPH1 and nephrin.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Phuong Tran Pham, Daiju Fukuda, Sachiko Nishimoto, Joo-Ri Kim-Kaneyama, Xiao-Feng Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata, Koji Yamaguchi, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi, Michio Shimabukuro, Mitsutoshi Setou, Glen N. Barber, Masataka Sata
Summary: The study indicates that the stimulator of interferon genes (STING) plays a role in atherosclerosis, and its signaling may serve as a potential therapeutic target for the disease by inhibiting STING activation to improve atherosclerosis progression.
EUROPEAN HEART JOURNAL
(2021)
Article
Chemistry, Physical
Sodiq O. Waheed, Ann Varghese, Shobhit S. Chaturvedi, Tatyana G. Karabencheva-Christova, Christo Z. Christov
Summary: This study investigates the effects of unnatural alkylated cytosine substrates on the binding interactions, reaction mechanism, and dynamics of the TET2 enzyme. The results reveal that the chemical nature of the substrates induces changes in the binding site, coordination sphere, and long-range correlated motions of the enzyme-substrate complexes. The rate-determining hydrogen atom transfer is faster in N4-methylated substrates compared to C5-alkylated substrates. The use of unnatural substrates allows for the measurement of TET activity or the capture of TET from cellular samples.
Review
Cell & Tissue Engineering
Zhao-Lin Zeng, Xiao-long Lin, Li-Lan Tan, Ya-Mi Liu, Kai Qu, Zuo Wang
STEM CELL REVIEWS AND REPORTS
(2018)
Review
Cell & Tissue Engineering
Zhao-Lin Zeng, Xiao-long Lin, Li-Lan Tan, Ya-Mi Liu, Kai Qu, Zuo Wang
STEM CELL REVIEWS AND REPORTS
(2018)
Review
Cell Biology
Zeng Zhaolin, Li Guohua, Wu Shiyuan, Wang Zuo
CELL PROLIFERATION
(2019)
Article
Cell Biology
Zeng Zhaolin, Chen Jiaojiao, Wu Peng, Liu Yami, Zhang Tingting, Tao Jun, Wu Shiyuan, Xiao Jinyan, Wei Dangheng, Jiang Zhisheng, Wang Zuo
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Lin Xiaolong, Guo Dongmin, Mihua Liu, Wang Zuo, Hu Huijun, Tan Qiufen, Hu XueMei, Lin Wensheng, Pan Yuping, Lin Jun, Zeng Zhaolin
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Oncology
Zhaolin Zeng, Qiuping Zheng, Jiaojiao Chen, Xianhua Tan, Qiang Li, Lingxin Ding, Ren Zhang, Xiaolong Lin
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Junfa Zeng, Jun Tao, Linzhen Xia, Zhaolin Zeng, Jiaojiao Chen, Zuo Wang, Jun Meng, Lushan Liu
Summary: Melatonin prevents endothelial cell pyroptosis by up-regulating TET2 to inhibit the methylation of UQCRC1 and improving mitochondrial function, thereby inhibiting oxidative stress and endothelial cell pyroptosis.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Review
Cell Biology
Z. L. Zeng, Qingyun Zhu, Zhibo Zhao, Xuyu Zu, Jianghua Liu
Summary: MiR-32 is a small noncoding RNA molecule that regulates gene expression by base pairing with mRNA, playing important roles in various diseases with both oncogenic and tumor-suppressive effects, as well as crucial roles in metabolic and cardiovascular disorders. New findings suggest its potential as a noninvasive biomarker and targeted therapeutic in multiple diseases.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Neurosciences
Menglin Li, Xiaolin Zhong, Zhibo Zhao, Zhaolin Zeng, Qing Yuan, Xinhua Xiao, Xuyu Zu, Jianghua Liu
Summary: This study investigated the expression of the m6A enzyme in the hippocampus of mice with diabetes-induced cognitive impairment and explored the potential improvement with overexpression of YTHDF1. The results suggest that the m6A enzyme may play a key role in cognitive dysfunction induced by diabetes, and YTHDF1 may be a promising therapeutic target.
Article
Engineering, Biomedical
Yijia Liao, Yiguo Yan, Yu Kang, Wenjun Wang, Xizheng Song, Wen Peng, Haibin Fu, Huarong Chen, Cheng Wang
Summary: This study compared the biomechanical characteristics of external spinal fixation and internal fixation system for treating lumbar fracture through finite element analysis. The results showed that the external fixation system had a better stress distribution and overall mobility compared to the internal fixation system.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2022)
Article
Cell Biology
Yingying Shen, Qingyun Zhu, Maoyu Xiao, Liyang Yin, Wenjie Feng, Jianbo Feng, Jun He, Pei Li, Xiguang Chen, Wenjun Ding, Jing Zhong, Zhaolin Zeng, Zhuoye Xie, Jianghua Liu, Xuyu Zu
Summary: This study found that the small-molecule tyrosine kinase inhibitor DCC-2036 can suppress breast cancer stem cells by inhibiting the AXL and KLF5 proteins. Additionally, DCC-2036 has the potential to increase the effectiveness of chemotherapy for TNBC.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Qing Yuan, Z. L. Zeng, Shiqi Yang, Anqi Li, Xuyu Zu, Jianghua Liu
Summary: Energy intake and metabolic balance are crucial for maintaining health. Overnutrition can cause metabolic inflammation, leading to various metabolic disorders. Mitochondrial dysfunction is closely associated with metabolic inflammation. Excellent organism design can maintain metabolic health even in the presence of mitochondrial dysfunction.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Biotechnology & Applied Microbiology
Wen Peng, Yami Liu, Cheng Wang
Summary: Bioengineered porous bone tissue materials based on additive manufacturing technology have become a research hotspot. Research has been conducted on structural design, preparation and processing processes, and performance optimization. However, there is controversy in characterizing the pore structure dimensions of porous materials, leading to conflicts among researchers. This literature review analyzes different dimensional characterization parameters of pore structures to provide a theoretical basis for unified definitions and standardized use of parameters.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zeng Zhao-Lin, Chen Jiao-Jiao, Wang Zuo
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2018)
