The complexity of miRNA-mediated repression

The diverse roles of the eIF4A family: you are the company you keep

(2014) Wei-Ting Lu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Sumoylation of Human Argonaute 2 at Lysine-402 Regulates Its Stability

(2014) Umut Sahin et al.   PLoS One

Molecular Mechanisms of RNA Interference

(2013) Ross C. Wilson et al.   Annual Review of Biophysics

Argonaute and GW182 proteins: an effective alliance in gene silencing

(2013) Janina Pfaff et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes

(2013) Elmar Wahle et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

(2013) Latifa Zekri et al.   EMBO JOURNAL

Circular RNAs: splicing’s enigma variations

(2013) Matthias W Hentze et al.   EMBO JOURNAL

A transient reversal of miRNA-mediated repression controls macrophage activation

(2013) Anup Mazumder et al.   EMBO REPORTS

Biogenesis and the regulation of the maturation of miRNAs

(2013) Nham Tran et al.   Essays in Biochemistry

Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates

(2013) F. V. Karginov et al.   GENES & DEVELOPMENT

LIN-41/TRIM71: emancipation of a miRNA target

(2013) M. Ecsedi et al.   GENES & DEVELOPMENT

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire

(2013) Yelena Bronevetsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets

(2013) Shane R. Horman et al.   MOLECULAR CELL

Structure of the PAN3 Pseudokinase Reveals the Basis for Interactions with the PAN2 Deadenylase and the GW182 Proteins

(2013) Mary Christie et al.   MOLECULAR CELL

HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

(2013) Madhu S. Kumar et al.   NATURE

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo

(2013) Silvi Rouskin et al.   NATURE

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells

(2013) Robert L Judson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

miRISC recruits decapping factors to miRNA targets to enhance their degradation

(2013) T. Nishihara et al.   NUCLEIC ACIDS RESEARCH

miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity

(2013) Judit Remenyi et al.   PLoS One

HPat a Decapping Activator Interacting with the miRNA Effector Complex

(2013) Elisabeth Barišić-Jäger et al.   PLoS One

Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate

(2013) K.-L. Huang et al.   RNA

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR

(2013) M. Y. Balkhi et al.   Science Signaling

The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities

(2012) Matthew Brook et al.   BIOCHEMICAL JOURNAL

Regulation of signalling by microRNAs

(2012) Roi Avraham et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes

(2012) D Ferland-McCollough et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA biogenesis: regulating the regulators

(2012) Emily F. Finnegan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

(2012) Julien Béthune et al.   EMBO REPORTS

The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling

(2012) J. Chen et al.   GENES & DEVELOPMENT

Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction

(2012) Jérôme Basquin et al.   MOLECULAR CELL

Erratum: miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

(2012) Francesca Moretti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

(2012) Eric Huntzinger et al.   NUCLEIC ACIDS RESEARCH

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

(2012) Pradipta Kundu et al.   NUCLEIC ACIDS RESEARCH

Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer

(2012) Antonio Lembo et al.   PLoS One

Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish

(2012) Y. Mishima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cellular response linking eIF4AI activity to eIF4AII transcription

(2012) G. Galicia-Vazquez et al.   RNA

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

MicroRNA turnover: when, how, and why

(2012) Stefan Rüegger et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tricks an IRES uses to enslave ribosomes

(2012) Sunnie R. Thompson   TRENDS IN MICROBIOLOGY

Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation

(2012) Hao-Ming Chang et al.   Nature Communications

A Resource for the Conditional Ablation of microRNAs in the Mouse

(2012) Chong Yon Park et al.   Cell Reports

MicroRNA degradation and turnover: regulating the regulators

(2012) Zhuo Zhang et al.   Wiley Interdisciplinary Reviews-RNA

Biogenesis of Mammalian MicroRNAs: A Global View

(2012) Paul Graves et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

PABP is not essential for microRNA-mediated translational repression and deadenylationin vitro

(2011) Takashi Fukaya et al.   EMBO JOURNAL

The Ccr4–Not complex

(2011) Martine A. Collart et al.   GENE

Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2

(2011) C. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes

(2011) Olivia S. Rissland et al.   MOLECULAR CELL

Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

(2011) Martin Jinek et al.   MOLECULAR CELL

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2011) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of a microRNA response in trans reveals a new role for poly(A) in translational repression

(2011) Emiliano P. Ricci et al.   NUCLEIC ACIDS RESEARCH

Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs

(2010) Jacek Krol et al.   CELL

miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

(2010) Anna M. Eiring et al.   CELL

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Many Families of C. elegans MicroRNAs Are Not Essential for Development or Viability

(2010) Ezequiel Alvarez-Saavedra et al.   CURRENT BIOLOGY

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

(2010) Eric Huntzinger et al.   EMBO JOURNAL

Analysis of microRNA knockouts in mice

(2010) C. Y. Park et al.   HUMAN MOLECULAR GENETICS

Translational Repression by Deadenylases

(2010) Amy Cooke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Binding of P-body-associated Proteins GW182 and Ataxin-2 by the Mlle Domain of Poly(A)-binding Protein

(2010) Guennadi Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HPat provides a link between deadenylation and decapping in metazoa

(2010) Gabrielle Haas et al.   JOURNAL OF CELL BIOLOGY

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

(2010) Martin Jinek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA assassins: factors that regulate the disappearance of miRNAs

(2010) Zoya S Kai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of human Argonaute proteins affects small RNA binding

(2010) Sabine Rüdel et al.   NUCLEIC ACIDS RESEARCH

CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

(2010) Jiayi Wang et al.   NUCLEIC ACIDS RESEARCH

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

(2010) S Wu et al.   ONCOGENE

Phosphorylation of Not4p Functions Parallel to BUR2 to Regulate Resistance to Cellular Stresses in Saccharomyces cerevisiae

(2010) Nga-Chi Lau et al.   PLoS One

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

(2010) I. G. Cannell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans

(2009) Christopher M. Hammell et al.   CELL

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

(2009) Jens C. Schwamborn et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease

(2009) L Elia et al.   CELL DEATH AND DIFFERENTIATION

Redefining MicroRNA Targets

(2009) Hervé Seitz   CURRENT BIOLOGY

The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

(2009) L. Zekri et al.   MOLECULAR AND CELLULAR BIOLOGY

Drosophila miR2 Primarily Targets the m7GpppN Cap Structure for Translational Repression

(2009) Agnieszka Zdanowicz et al.   MOLECULAR CELL

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

(2009) Marc R. Fabian et al.   MOLECULAR CELL

Drosophila Argonaute1 and Argonaute2 Employ Distinct Mechanisms for Translational Repression

(2009) Shintaro Iwasaki et al.   MOLECULAR CELL

Structural Basis for the Mutually Exclusive Anchoring of P Body Components EDC3 and Tral to the DEAD Box Protein DDX6/Me31B

(2009) Felix Tritschler et al.   MOLECULAR CELL

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

(2009) Agnieszka Rybak et al.   NATURE CELL BIOLOGY

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

microRNAs at the synapse

(2009) Gerhard Schratt   NATURE REVIEWS NEUROSCIENCE

Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

(2009) Chyi-Ying A Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation

(2009) Sourav Banerjee et al.   NEURON

DAZL Relieves miRNA-Mediated Repression of Germline mRNAs by Controlling Poly(A) Tail Length in Zebrafish

(2009) Yasuaki Takeda et al.   PLoS One

Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development

(2009) Z. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression

(2009) R. W. Walters et al.   RNA

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

(2008) Yan Zeng et al.   BIOCHEMICAL JOURNAL

How do microRNAs regulate gene expression?

(2008) Ian G. Cannell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

(2008) Ralph A. Neumüller et al.   NATURE

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Prolyl 4-hydroxylation regulates Argonaute 2 stability

(2008) Hank H. Qi et al.   NATURE

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

(2008) Yi Wen Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the yeast eIF4A-eIF4G complex: An RNA-helicase controlled by protein-protein interactions

(2008) P. Schutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deadenylation is a widespread effect of miRNA regulation

(2008) A. Eulalio et al.   RNA