Journal
GENES
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/genes9040182
Keywords
stem cell; mitochondrial DNA mutation; ageing; purifying selection; mitochondrial mutagenesis; progenitor; mitochondrial disease; ageing mouse model; mitochondrial DNA-mutator mouse; mitochondria
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Funding
- Newcastle University Centre for Aging and Vitality - Biotechnology and Biological Sciences Research Council (BBSRC)
- Newcastle University Centre for Aging and Vitality - Engineering and Physical Sciences Research Council (EPSRC)
- Newcastle University Centre for Aging and Vitality - Economic and Social Research Council (ESRC)
- Newcastle University Centre for Aging and Vitality - Medical Research Council (MRC) as part of the cross-council Lifelong Health and Wellbeing Initiative
- Wellcome Centre for Mitochondrial Research [203105/Z/16/Z]
- UK National Institute for Health Research (NIHR) Biomedical Research Centre in Age and Age Related Diseases
- UK NHS Highly Specialized Service for Rare Mitochondrial Disorders of Adults and Children
- MRC [MR/L016354/1] Funding Source: UKRI
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Mitochondrial DNA (mtDNA) mutations accumulate in somatic stem cells during ageing and cause mitochondrial dysfunction. In this review, we summarize the studies that link mtDNA mutations to stem cell ageing. We discuss the age-related behaviours of the somatic mtDNA mutations in stem cell populations and how they potentially contribute to stem cell ageing by altering mitochondrial properties in humans and in mtDNA-mutator mice. We also draw attention to the diverse fates of the mtDNA mutations with different origins during ageing, with potential selective pressures on the germline inherited but not the somatic mtDNA mutations.
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