PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

Parkin regulates lipopolysaccharide-induced proinflammatory responses in acute lung injury

(2017) Eleftheria Letsiou et al.   Translational Research

Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation

(2017) Yu Yeon Jung et al.   Redox Biology

PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis

(2015) Saburo Ito et al.   Autophagy

Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

(2015) Tanveer Ahmad et al.   FASEB JOURNAL

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease

(2015) Patricia Martín-Maestro et al.   HUMAN MOLECULAR GENETICS

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

The association between chronic obstructive pulmonary disease and Parkinson’s disease: a nationwide population-based retrospective cohort study

(2014) C.-H. Li et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Selective Targeting of TGF-  Activation to Treat Fibroinflammatory Airway Disease

(2014) S. Minagawa et al.   Science Translational Medicine

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence

(2013) Hiromichi Hara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

(2013) E. S. Vincow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells

(2013) Roland F Hoffmann et al.   RESPIRATORY RESEARCH

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy

(2012) Aleksandar Rakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

Involvement of Creatine Kinase B in Cigarette Smoke–Induced Bronchial Epithelial Cell Senescence

(2011) Hiromichi Hara et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells

(2009) Marco van der Toorn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair

(2009) Oliver Rothfuss et al.   HUMAN MOLECULAR GENETICS

Superoxide scavenging activity of pirfenidone–iron complex

(2008) Yoshihiro Mitani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis

(2008) Hisashi Oku et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE