Article
Biochemistry & Molecular Biology
Olena Kalashnyk, Olena Lykhmus, Mykhailo Izmailov, Lyudmyla Koval, Serhiy Komisarenko, Maryna Skok
Summary: Despite many studies, details of the interactions between SARS-Cov-2 and human cells remain poorly understood. Research suggests that a specific fragment of the SARS-Cov-2 spike protein may compete with antibodies against certain receptors, affecting mitochondrial regulation and apoptosis, potentially impacting virus replication and cell survival.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Maryna Skok
Summary: Nicotinic acetylcholine receptors play important roles in multiple cellular functions, including synaptic transmission, cell survival and proliferation, and the release of neurotransmitters or cytokines. Glycosylated nicotinic acetylcholine receptors in mitochondria regulate the release of pro-apoptotic substances, while mitochondrial nicotinic acetylcholine receptors interact with Bcl-2 family proteins and are involved in important pathologies such as neuroinflammation, liver damage, and SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Environmental Sciences
Zhi Cheng, Da Wang, Shipeng Han, Cheng Zuo, Yunzhuan He
Summary: This study identified differentially expressed genes associated with thiamethoxam resistance in the seven-spot ladybird beetle through transcriptome sequencing. Up-regulation of certain metabolic enzymes and transport proteins, as well as down-regulation of nicotinic acetylcholine receptor gene, were observed in the resistant strain.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Food Science & Technology
Paulina Patalas-Krawczyk, Dominika Malinska, Jaroslaw Walczak, Gilles Kratzer, Monika Prill, Bernadeta Michalska, Karolina Drabik, Bjorn Titz, Yvan Eb-Levadoux, Thomas Schneider, Jedrzej Szymanski, Julia Hoeng, Manuel C. Peitsch, Jerzy Duszynski, Joanna Szczepanowska, Marco Van der Toorn, Carole Mathis, Mariusz R. Wieckowski
Summary: Mitochondria play an important role in responding to stress factors, and alkaloids from tobacco plants such as nicotine, anatabine, and anabasine can modulate mitochondrial activities differently in mouse brain and liver tissues. These alkaloids affect mitochondrial bioenergetics parameters, including oxygen consumption and swelling rates, with potential toxic effects observed in liver mitochondria. The observed effects are likely independent of nicotinic acetylcholine receptors based on quantitative proteomic analysis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Lee Jones, Callum Waite, Edgar Neri-Castro, Bryan G. Fry
Summary: The distribution and potency of post-synaptic neurotoxic activity in Crotalinae venoms, particularly within the Atropoides, Metlapilcoatlus, Cerrophidion, and Porthidium clade, were investigated. The study revealed potent binding activity in venoms from certain snake species, indicating the presence of toxins that bind to post-synaptic receptors. This finding highlights the need for further research on the neurotoxic activity in these poorly studied snakes.
Article
Engineering, Environmental
Stephen Short, Alex Robinson, Elma Lahive, Amaia Green Etxabe, Szabolcs Hernadi, M. Gloria Pereira, Peter Kille, David J. Spurgeon
Summary: Neonicotinoids, widely used in 120 countries, require accurate prediction of nontarget species sensitivity. Combining toxicology with toxicogenomics can improve predictions and identify susceptible species. Variations in AChBP expression can explain differential species sensitivity to neonicotinoids.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Takehito Terajima, Tomonori Suzuki, Ryo Horikoshi, Shohei Doi, Mizuki Nakamura, Fumika Kobayashi, Kathleen A. Durkin, Kenji Shimomura, Satoshi Nakamura, Kazumi Yamamoto, Motohiro Tomizawa
Summary: This study investigates the binding mechanism of a novel insecticide FLP with insect nAChR, finding that FLP primarily binds to the beta subunit of nAChR; the results suggest that the interaction between FLP and T77R, T77K, T77N, or T77Q nAChR enhances the drug's binding potency.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Edouard Montigne, David Balayssac
Summary: This scoping review provides an overview of studies on peripheral neuropathic pain (PNP) in rodent models, exploring compounds targeting cholinergic neurotransmission. The results highlight the potential of cholinergic compounds for the management of neuropathic pain, emphasizing the need for clinical trials.
Article
Neurosciences
Melissa A. Tapia, Xiao-Tao Jin, Brenton R. Tucker, Leanne N. Thomas, Noah B. Walker, Veronica J. Kim, Steven E. Albertson, Naresh Damuka, Ivan Krizan, Seby Edassery, Jeffrey N. Savas, Kiran Kumar Solingapuram Sai, Sara R. Jones, Ryan M. Drenan
Summary: This study investigated the behavior and neurobiological effects of intermittent nicotine intake in rats. The results suggest that intermittent nicotine intake may lead to increased craving and enhanced response to nicotine-associated cues. Additionally, intermittent nicotine intake also caused increased nicotine binding in the brain and specific changes in the proteome of certain neural structures.
Article
Neurosciences
Xiao-Tao Jin, Ryan M. Drenan
Summary: The interpeduncular nucleus (IPN) is involved in nicotine dependence and regulation of fear responses, affective states, and novelty processing. Neurons in the IPN express nicotinic acetylcholine receptors (nAChR) and receive cholinergic innervation. Studies have shown that IPL neurons express Chrna7 (alpha 7 nAChR subunit) and are sensitive to acetylcholine (ACh) stimulation. These findings contribute to a better understanding of cholinergic modulation in the IPN.
Article
Biochemistry & Molecular Biology
Yoshihisa Ozoe, Yoshiki Matsubara, Yuji Tanaka, Yasuhide Yoshioka, Fumiyo Ozoe, Takahiro Shiotsuki, Kazuki Nomura, Toshifumi Nakao, Shinichi Banba
Summary: Dinotefuran is a unique insecticide that acts on specific nicotinic acetylcholine receptor (nAChR) subtypes, leading to differences in its insecticidal activity compared to imidacloprid.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Food Science & Technology
Uthpala Chandrasekara, Richard J. Harris, Bryan G. Fry
Summary: This study reveals the specific amino acid positions in King Cobra venom that selectively bind to their prey's physiological pathways. The findings show that three negatively charged amino acids in the venom strongly bind to neurotoxins, shedding light on the evolution of lineage-selective toxins driven by specialist prey.
Article
Biochemistry & Molecular Biology
Olena Kalashnyk, Olena Lykhmus, Lyudmyla Koval, Kateryna Uspenska, Maria Obolenskaya, Volodymyr Chernyshov, Serhiy Komisarenko, Maryna Skok
Summary: The study shows the presence of a7 subtype nicotinic acetylcholine receptors (nAChRs) in the nuclei of liver cells and astrocytoma U373 cell line. These nuclear a7 nAChRs are up-regulated in liver after partial hepatectomy and in H2O2-treated U373 cells. They interact with hypoxia-inducible factor HIF-1a and influence its translocation into the nucleus and mitochondria upon hypoxia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Rebecca J. Howard
Summary: The superfamily of pentameric ligand-gated ion channels plays crucial roles in electrochemical signal transduction across evolution, with increasing structural studies focusing on three model subfamilies. Common themes include gating mechanisms and diversity beyond the protein level.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Physiology
Niyati A. Borkar, Michael A. Thompson, Colleen M. Bartman, Venkatachalem Sathish, Y. S. Prakash, Christina M. Pabelick
Summary: Exposure to nicotine from cigarette smoke and e-cigarettes can increase health risks associated with asthma by affecting airway dynamics. Nicotine disrupts mitochondrial morphology and balance between fusion and fission, impairs mitochondrial calcium regulation, and alters mitochondrial respiratory and bioenergetic functions in airway smooth muscle cells. These effects are mediated through the alpha 7 subtype of the nicotinic acetylcholine receptor.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)