Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment

Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene

(2016) Nikolai L. Chepelev et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

(2016) Ila Cote et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Comparative transcriptomic analyses to scrutinize the assumption that genotoxic PAHs exert effects via a common mode of action

(2015) S. Labib et al.   ARCHIVES OF TOXICOLOGY

Toxicogenomic assessment of liver responses following subchronic exposure to furan in Fischer F344 rats

(2015) Hongyan Dong et al.   ARCHIVES OF TOXICOLOGY

Integrating toxicogenomics into human health risk assessment: Lessons learned from the benzo[a]pyrene case study

(2015) Nikolai L. Chepelev et al.   CRITICAL REVIEWS IN TOXICOLOGY

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water

(2015) Ivy Moffat et al.   CRITICAL REVIEWS IN TOXICOLOGY

BMDExpress Data Viewer - a visualization tool to analyze BMDExpress datasets

(2015) Byron Kuo et al.   JOURNAL OF APPLIED TOXICOLOGY

Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals

(2015) Julie A. Bourdon-Lacombe et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Transcriptional Profiling of Dibenzo[def,p]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse

(2015) Nikolai L. Chepelev et al.   TOXICOLOGICAL SCIENCES

Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded Tissues

(2015) A. Francina Webster et al.   TOXICOLOGICAL SCIENCES

Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD)

(2015) A. Francina Webster et al.   PLoS One

Standardizing Benchmark Dose Calculations to Improve Science-Based Decisions in Human Health Assessments

(2014) Jessica A. Wignall et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A Framework for the Next Generation of Risk Science

(2014) Daniel Krewski et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

RNA-Seq-based toxicogenomic assessment of fresh frozen and formalin-fixed tissues yields similar mechanistic insights

(2014) Scott S. Auerbach et al.   JOURNAL OF APPLIED TOXICOLOGY

Comparison of Microarrays and RNA-Seq for Gene Expression Analyses of Dose-Response Experiments

(2013) Michael B. Black et al.   TOXICOLOGICAL SCIENCES

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Concordance of Transcriptional and Apical Benchmark Dose Levels for Conazole-Induced Liver Effects in Mice

(2013) Virunya S. Bhat et al.   TOXICOLOGICAL SCIENCES

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan

(2013) Anna Francina Jackson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Subchronic Hepatotoxicity Evaluation of Hydrazobenzene in Fischer 344 Rats

(2012) Darol E. Dodd et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Subchronic Hepatotoxicity Evaluation of 1,2,4-Tribromobenzene in Sprague-Dawley Rats

(2012) Darol E. Dodd et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats

(2012) Darol E. Dodd et al.   JOURNAL OF APPLIED TOXICOLOGY

Subchronic urinary bladder toxicity evaluation of N-Nitrosodiphenylamine in Fischer 344 rats

(2012) Darol E. Dodd et al.   JOURNAL OF APPLIED TOXICOLOGY

Subchronic Thyroid Toxicity Evaluation of 4,4′-Methylenebis(N,N′-Dimethyl)Aniline in Fischer 344 Rats

(2012) Darol E. Dodd et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

(2012) Russell S. Thomas et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

(2012) Michael B. Black et al.   TOXICOLOGICAL SCIENCES

Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure

(2012) Julie A. Bourdon et al.   TOXICOLOGY

Concentration- and Time-dependent Genomic Changes in the Mouse Urinary Bladder Following Exposure to Arsenate in Drinking Water for up to 12 Weeks

(2011) H. J. Clewell et al.   TOXICOLOGICAL SCIENCES

The U.S. Environmental Protection Agency Strategic Plan for Evaluating the Toxicity of Chemicals

(2010) Michael Firestone et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicogenomics and cancer risk assessment: A framework for key event analysis and dose–response assessment for nongenotoxic carcinogens

(2010) Joel P. Bercu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Formaldehyde: Integrating Dosimetry, Cytotoxicity, and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Application of Transcriptional Benchmark Dose Values in Quantitative Cancer and Noncancer Risk Assessment

(2010) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Introduction to benchmark dose methods and U.S. EPA's benchmark dose software (BMDS) version 2.1.1

(2010) J. Allen Davis et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches

(2008) Kathryn Z. Guyton et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH