The Gut and Parkinson's Disease—A Bidirectional Pathway

Intestinal bacteria modulate the foraging behavior of the oriental fruit fly Bactrocera dorsalis (Diptera: Tephritidae)

(2019) Mazarin Akami et al.   PLoS One

Microbiome, Parkinson’s Disease and Molecular Mimicry

(2019) Fabiana Miraglia et al.   Cells

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis

(2019) Lasha Gogokhia et al.   Cell Host & Microbe

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

(2018) Carolina Pellegrini et al.   ACTA NEUROPATHOLOGICA

A probiotic modulates the microbiome and immunity in multiple sclerosis

(2018) Stephanie K. Tankou et al.   ANNALS OF NEUROLOGY

NGL viewer: web-based molecular graphics for large complexes

(2018) Alexander S Rose et al.   BIOINFORMATICS

The concept of alpha-synuclein as a prion-like protein: ten years after

(2018) Jennifer A. Steiner et al.   CELL AND TISSUE RESEARCH

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

The role of functional amyloids in bacterial virulence

(2018) Nani Van Gerven et al.   JOURNAL OF MOLECULAR BIOLOGY

Why does the microbiome affect behaviour?

(2018) Katerina V.-A. Johnson et al.   NATURE REVIEWS MICROBIOLOGY

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

(2018) Filipe De Vadder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

(2018) Sigrid Breit et al.   Frontiers in Psychiatry

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

A gut feeling

(2018) Benjamin U. Hoffman et al.   SCIENCE

Parkinson’s disease and bacteriophages as its overlooked contributors

(2018) George Tetz et al.   Scientific Reports

Probiotic Safety—No Guarantees

(2018) Pieter A. Cohen   JAMA Internal Medicine

Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment

(2018) Ayami Okuzumi et al.   Acta Neuropathologica Communications

Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

(2018) Gene L. Bowman et al.   Alzheimers & Dementia

Exogenous and Endogenous Neuroactive Biogenic Amines: Studies with Lactococcus lactis subsp. lactis

(2018) I. R. Vodolazov et al.   APPLIED BIOCHEMISTRY AND MICROBIOLOGY

A gut microbial factor modulates locomotor behaviour in Drosophila

(2018) Catherine E. Schretter et al.   NATURE

Bacteriophages shift the focus of the mammalian microbiota

(2018) Breck A. Duerkop   PLoS Pathogens

Production of the Neurotoxin Salsolinol by a Gut-Associated Bacterium and Its Modulation by Alcohol

(2018) Daniel N. Villageliú et al.   Frontiers in Microbiology

Exploring Interactions between the Gut Microbiota and Social Behavior through Nutrition

(2018) Cristian Pasquaretta et al.   Genes

GABA-modulating bacteria of the human gut microbiota

(2018) Philip Strandwitz et al.   Nature Microbiology

The prion model for progression and diversity of neurodegenerative diseases

(2017) Barbara E Stopschinski et al.   LANCET NEUROLOGY

The evolution of the host microbiome as an ecosystem on a leash

(2017) Kevin R. Foster et al.   NATURE

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

(2017) Ruixin Liu et al.   NATURE MEDICINE

The mucosal immune system: master regulator of bidirectional gut–brain communications

(2017) Nick Powell et al.   Nature Reviews Gastroenterology & Hepatology

The first brain: Species comparisons and evolutionary implications for the enteric and central nervous systems

(2017) J. B. Furness et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Vagotomy and Parkinson disease

(2017) Bojing Liu et al.   NEUROLOGY

Salsolinol: an Unintelligible and Double-Faced Molecule—Lessons Learned from In Vivo and In Vitro Experiments

(2017) Magdalena Kurnik-Łucka et al.   NEUROTOXICITY RESEARCH

Involvement of the kynurenine pathway in the pathogenesis of Parkinson’s disease

(2017) Chai K. Lim et al.   PROGRESS IN NEUROBIOLOGY

Designer Probiotics: Paving the Way to Living Therapeutics

(2017) Birbal Singh et al.   TRENDS IN BIOTECHNOLOGY

Bacteria–Bacteriophage Coevolution in the Human Gut: Implications for Microbial Diversity and Functionality

(2017) Pauline D. Scanlan   TRENDS IN MICROBIOLOGY

The Human Gut Phage Community and Its Implications for Health and Disease

(2017) Pilar Manrique et al.   Viruses-Basel

Microbes can help explain the evolution of host altruism

(2017) Ohad Lewin-Epstein et al.   Nature Communications

Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients

(2017) J. R. Bedarf et al.   Genome Medicine

The MPTP Story

(2017) J. William Langston   Journal of Parkinsons Disease

The role of microbial amyloid in neurodegeneration

(2017) Robert P. Friedland et al.   PLoS Pathogens

Human Gut Microbiota: Toward an Ecology of Disease

(2017) Susannah Selber-Hnatiw et al.   Frontiers in Microbiology

Cross Talk: The Microbiota and Neurodevelopmental Disorders

(2017) John R. Kelly et al.   Frontiers in Neuroscience

Parkinson Disease: An Evolutionary Perspective

(2017) Pedro J. Garcia-Ruiz et al.   Frontiers in Neurology

Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson’s disease

(2017) Martina Barrenschee et al.   Acta Neuropathologica Communications

The genetic background of Parkinson's disease: current progress and future prospects

(2016) K. Kalinderi et al.   ACTA NEUROLOGICA SCANDINAVICA

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Amyloid Structures as Biofilm Matrix Scaffolds

(2016) Agustina Taglialegna et al.   JOURNAL OF BACTERIOLOGY

The bowel and beyond: the enteric nervous system in neurological disorders

(2016) Meenakshi Rao et al.   Nature Reviews Gastroenterology & Hepatology

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probiotics and prebiotic fiber for constipation associated with Parkinson disease

(2016) Michela Barichella et al.   NEUROLOGY

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

Cospeciation of gut microbiota with hominids

(2016) A. H. Moeller et al.   SCIENCE

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phage Therapy: Combating Infections with Potential for Evolving from Merely a Treatment for Complications to Targeting Diseases

(2016) Andrzej Górski et al.   Frontiers in Microbiology

The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling

(2016) Roberto Mazzoli et al.   Frontiers in Microbiology

Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review

(2016) Huiying Wang et al.   Journal of Neurogastroenterology and Motility

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Olfaction and Aging: A Mini-Review

(2015) Johannes Attems et al.   GERONTOLOGY

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Enteroendocrine cells: a review of their role in brain-gut communication

(2015) R. Latorre et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Evolution of eumetazoan nervous systems: insights from cnidarians

(2015) Iva Kelava et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota

(2014) Jeffrey D Galley et al.   BMC MICROBIOLOGY

Non-motor symptoms of Parkinson's disease A review…from the past

(2014) Pedro J. Garcia-Ruiz et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Phage cocktails and the future of phage therapy

(2013) Benjamin K Chan et al.   Future Microbiology

Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects

(2013) Madison T. Gray et al.   MOVEMENT DISORDERS

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Does acute tryptophan depletion affect peripheral serotonin metabolism in the intestine?

(2012) Daniel Keszthelyi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Expression pattern and localization of alpha-synuclein in the human enteric nervous system

(2012) Martina Böttner et al.   NEUROBIOLOGY OF DISEASE

Intestinal microbiota in human health and disease: the impact of probiotics

(2011) Jacoline Gerritsen et al.   Genes and Nutrition

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

Probiotic Lactobacilli Interfere with Streptococcus mutans Biofilm Formation In Vitro

(2010) Eva M. Söderling et al.   CURRENT MICROBIOLOGY

The brain to gut pathway: a possible route of prion transmission

(2010) Victoria A Lawson et al.   GUT

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Incidence and remaining lifetime risk of Parkinson disease in advanced age

(2009) J. A. Driver et al.   NEUROLOGY

Viral parkinsonism

(2008) Haeman Jang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Worlds within worlds: evolution of the vertebrate gut microbiota

(2008) Ruth E. Ley et al.   NATURE REVIEWS MICROBIOLOGY

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease

(2008) Jan Gründemann et al.   NUCLEIC ACIDS RESEARCH

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE