In the Right Place, at the Right Time: Spatiotemporal Conditions Determining Plasma Cell Survival and Function

Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow

(2018) Konrad Haberland et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

No strict requirement for eosinophils for bone marrow plasma cell survival

(2018) Alexandra Bortnick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors

(2018) Tobias Alexander et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

(2018) Andreia C. Lino et al.   IMMUNITY

NAD(P)H Oxidase Activity in the Small Intestine Is Predominantly Found in Enterocytes, Not Professional Phagocytes

(2018) Randall Lindquist et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phasor-Based Endogenous NAD(P)H Fluorescence Lifetime Imaging Unravels Specific Enzymatic Activity of Neutrophil Granulocytes Preceding NETosis

(2018) Ruth Leben et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Old and Young Actors Playing Novel Roles in the Drama of Multiple Myeloma Bone Marrow Microenvironment Dependent Drug Resistance

(2018) Sabrina Manni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

(2018) Yang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

(2018) Hsin-Ying Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplexed fluorescence microscopy reveals heterogeneity among stromal cells in mouse bone marrow sections

(2018) Karolin Holzwarth et al.   CYTOMETRY PART A

OUP accepted manuscript

(2018)   NEPHROLOGY DIALYSIS TRANSPLANTATION

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function

(2018) Virginia Andreani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

(2018) Doan C. Nguyen et al.   Nature Communications

Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

(2017) Nike J. Kräutler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody-secreting plasma cells persist for decades in human intestine

(2017) Ole J.B. Landsverk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ocrelizumab and Other CD20+ B-Cell-Depleting Therapies in Multiple Sclerosis

(2017) Jeffrey M. Gelfand et al.   Neurotherapeutics

Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature

(2017) David Reismann et al.   Nature Communications

Flow Dynamics and HSPC Homing in Bone Marrow Microvessels

(2017) M. Gabriele Bixel et al.   Cell Reports

T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow

(2017) Arielle Glatman Zaretsky et al.   Cell Reports

Analyzing Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Aging and Vascular Amyloid Pathology

(2017) Helena Radbruch et al.   Frontiers in Immunology

The chronically inflamed central nervous system provides niches for long-lived plasma cells

(2017) Karolin Pollok et al.   Acta Neuropathologica Communications

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

(2016) V. G. Bhoj et al.   BLOOD

Human cerebrospinal fluid monoclonalN-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

(2016) Jakob Kreye et al.   BRAIN

Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation

(2016) Ana Cordeiro Gomes et al.   IMMUNITY

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

(2016) Wing Y. Lam et al.   IMMUNITY

Autophagy in Plasma Cell Ontogeny and Malignancy

(2016) Enrico Milan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

mTOR has distinct functions in generating versus sustaining humoral immunity

(2016) Derek D. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis

(2016) Franziska Scheibe et al.   NEUROLOGY

Ongoing Oxidative Stress Causes Subclinical Neuronal Dysfunction in the Recovery Phase of EAE

(2016) Helena Radbruch et al.   Frontiers in Immunology

Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation

(2015) Agata A. Mossakowski et al.   ACTA NEUROPATHOLOGICA

The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus

(2015) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow

(2015) H. E. Mei et al.   BLOOD

Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow

(2015) Jessica L. Halliley et al.   IMMUNITY

Emergence of long-lived autoreactive plasma cells in the spleen of primary warm auto-immune hemolytic anemia patients treated with rituximab

(2015) Matthieu Mahévas et al.   JOURNAL OF AUTOIMMUNITY

c-Myb is required for plasma cell migration to bone marrow after immunization or infection

(2015) Kim L. Good-Jacobson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif

(2015) Cheryl H. Rozanski et al.   JOURNAL OF IMMUNOLOGY

Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice

(2015) A Lemke et al.   Mucosal Immunology

Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors

(2015) Adriano Taddeo et al.   ARTHRITIS RESEARCH & THERAPY

Mir-17–92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c

(2015) Shengli Xu et al.   Nature Communications

Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice

(2015) Laleh Khodadadi et al.   PLoS One

Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells

(2014) Sandra Zehentmeier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Eosinophils Promote Generation and Maintenance of Immunoglobulin-A-Expressing Plasma Cells and Contribute to Gut Immune Homeostasis

(2014) Van Trung Chu et al.   IMMUNITY

Multiphoton fluorescence lifetime imaging microscopy reveals free-to-bound NADH ratio changes associated with metabolic inhibition

(2014) Krystyna Drozdowicz-Tomsia et al.   JOURNAL OF BIOMEDICAL OPTICS

Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL

(2014) M. J. Benson et al.   JOURNAL OF IMMUNOLOGY

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool

(2014) Yan-Feng Li et al.   Nature Communications

Autoantibodies from long-lived ‘memory’ plasma cells of NZB/W mice drive immune complex nephritis

(2013) Qingyu Cheng et al.   ANNALS OF THE RHEUMATIC DISEASES

Tracking plasma cell differentiation and survival

(2013) Katrin Roth et al.   CYTOMETRY PART A

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

Parallelized TCSPC for Dynamic Intravital Fluorescence Lifetime Imaging: Quantifying Neuronal Dysfunction in Neuroinflammation

(2013) Jan Leo Rinnenthal et al.   PLoS One

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis

(2012) Christina Elliott et al.   BRAIN

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells

(2012) Matthieu Mahévas et al.   JOURNAL OF CLINICAL INVESTIGATION

High Rate of Antibody Secretion Is not Integral to Plasma Cell Differentiation as Revealed by XBP-1 Deficiency

(2012) N. Taubenheim et al.   JOURNAL OF IMMUNOLOGY

Homing and Adhesion Patterns Determine the Cellular Composition of the Bone Marrow Plasma Cell Niche

(2012) E. Belnoue et al.   JOURNAL OF IMMUNOLOGY

Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens

(2012) A. Bortnick et al.   JOURNAL OF IMMUNOLOGY

The Tetraspanin CD37 Orchestrates the  4 1 Integrin-Akt Signaling Axis and Supports Long-Lived Plasma Cell Survival

(2012) A. B. van Spriel et al.   Science Signaling

Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow

(2011) T. Matthes et al.   BLOOD

High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice

(2011) Charlotte Starke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells

(2011) Cheryl H. Rozanski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-Lived Plasma Cells from Human Small Intestine Biopsies Secrete Immunoglobulins for Many Weeks In Vitro

(2011) L. Mesin et al.   JOURNAL OF IMMUNOLOGY

Relationship Between NMO-Antibody and Anti–MOG Antibody in Optic Neuritis

(2011) Takeshi Kezuka et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Intrathecally synthesized IgG in multiple sclerosis cerebrospinal fluid recognizes identical epitopes over time

(2011) Xiaoli Yu et al.   JOURNAL OF NEUROIMMUNOLOGY

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

(2011) Falk Hiepe et al.   Nature Reviews Rheumatology

Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue

(2011) C. Stringari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow

(2010) O. Winter et al.   BLOOD

Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease

(2010) S. Sarantopoulos et al.   BLOOD

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Development and Migration of Plasma Cells in the Mouse Lymph Node

(2010) David R. Fooksman et al.   IMMUNITY

Basophils Support the Survival of Plasma Cells in Mice

(2010) M. R. Gomez et al.   JOURNAL OF IMMUNOLOGY

Local Renal Autoantibody Production in Lupus Nephritis

(2010) M. Espeli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus

(2009) Van Trung Chu et al.   ARTHRITIS AND RHEUMATISM

The hematopoietic stem cell niche: Low in oxygen but a nice place to be

(2009) Pernilla Eliasson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The third dimension of ELISPOTs: Quantifying antibody secretion from individual plasma cells

(2009) Erin Bromage et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Dendritic Cells and Monocyte/Macrophages That Create the IL-6/APRIL-Rich Lymph Node Microenvironments Where Plasmablasts Mature

(2009) E. Mohr et al.   JOURNAL OF IMMUNOLOGY

Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 Mice

(2009) Kristin Fenton et al.   PLoS One

APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa

(2008) Bertrand Huard et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice

(2008) SL Lui et al.   LUPUS

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice

(2008) S. L. Lui et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Phasor Approach to Fluorescence Lifetime Imaging Analysis

(2007) Michelle A. Digman et al.   BIOPHYSICAL JOURNAL