Article
Cell Biology
Yuzhen Wang, Yingchun Wang, Wen Liu, Lu Ding, Xiaodi Zhang, Bo Wang, Zheng Tong, Xuetian Yue, Chunyang Li, Liyun Xu, Zhuanchang Wu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Summary: The study found that T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the growth and proliferation of lung cancer cells by enhancing mitochondrial fusion and oxidative phosphorylation pathway.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Applied
Suresh Sulekha Dhanisha, Sudarsanan Drishya, Chandrasekharan Guruvayoorappan
Summary: In this study, macrophage membrane-coated liposome-based biomimetic nanoparticles were developed to improve the in vivo bioavailability of Naringenin (NG). The nanoparticles exhibited good biocompatibility, stability, and pH-responsive drug release kinetics, leading to higher cellular uptake in vitro. The anti-metastatic efficacy of NG-loaded biomimetic nanoparticles was confirmed in experimental models, indicating its potential for reducing metastatic colonies in the lungs.
Article
Environmental Sciences
Yunhuan Liu, Weili Kang, Shuiping Liu, Jinyan Li, Jinyan Liu, Xingxiang Chen, Fang Gan, Kehe Huang
Summary: This study reveals a new mechanism of Cd-induced liver injury, in which Cd exposure leads to dysbiosis of gut microbiota, reduces fecal bile salt hydrolase activity, and increases the level of a certain substance in the intestine, thereby inhibiting intestinal FXR/FGF-15 signaling, increasing hepatic bile acid synthesis, and ultimately facilitating hepatic ductular proliferation, inflammation, and injury in mice.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Neurosciences
Yoshiki Sakai, Mayuka Tsunekawa, Kohei Ohta, Tatsuhiro Shimizu, Strahil Iv. Pastuhov, Hiroshi Hanafusa, Naoki Hisamoto, Kunihiro Matsumoto
Summary: In Caenorhabditis elegans hermaphrodites, axon injury activates TLN-1/talin through the cAMP-Epac-Rap GTPase cascade, leading to integrin inside-out activation and subsequent activation of the RhoA-ROCK signaling pathway. The C. elegans integrin signaling network regulates axon regeneration through the Src-RhoGEF-RhoA axis.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Oncology
Nor Idayu A. Rahman, Akira Sato, Khurelbaatar Tsevelnorov, Akio Shimizu, Masahiro Komeno, Mohammad Khusni Bin Ahmat Amin, Md Rasel Molla, Joanne Ern Chi Soh, Le Kim Chi Nguyen, Akinori Wada, Akihiro Kawauchi, Hisakazu Ogita
Summary: Stromal-induced stomatin expression in prostate cancer cells suppresses tumor growth by inhibiting the Akt signaling axis, with clinical relevance shown in decreased stomatin levels in high Gleason score prostate cancer samples and higher recurrence rates post-operation.
Article
Medicine, Research & Experimental
Scott M. Haake, Erin J. Plosa, Jonathan A. Kropski, Lindsay A. Venton, Anupama Reddy, Fabian Bock, Betty T. Chang, Allen J. Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A. Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V. Polosukhin, Olga M. Viquez, Angela Jones, Wentian Luo, Matthew H. Wilson, W. Kimryn Rathmell, Pierre P. Massion, Ambra Pozzi, Timothy S. Blackwell, Roy Zent
Summary: Integrin α1 plays a critical role in the development and progression of lung adenocarcinoma by activating focal adhesion kinase (FAK) through cytoplasmic tail signaling, independent of ECM binding.
Article
Oncology
Shaosen Zhang, Caihong Wang, Jiujun Ju, Caixia Wang
Summary: In this study, we uncovered the novel molecular mechanism of extracellular heat shock protein 90 alpha (eHsp90 alpha) in regulating the activity of pyruvate kinase M2 (PKM2) during tumor progression, which benefits the development of new treatments against lung cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuefeng Li, Cheng Li, Chenchen Guo, Qiqi Zhao, Jiayu Cao, Hsin-Yi Huang, Meiting Yue, Yun Xue, Yujuan Jin, Liang Hu, Hongbin Ji
Summary: The heterogeneity of SCLC phenotype is associated with different sensitivity to chemotherapy; activation of the PI3K/Akt/mTOR pathway promotes phenotypic transition and chemo-resistance in SCLC cells; combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors can overcome chemo-resistance in SCLC treatment.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Cell Biology
Cefan Zhou, Yanyan Liang, Li Zhou, Yanan Yan, Nanxi Liu, Rui Zhang, Yuan Huang, Ming Wang, Yongfei Tang, Declan William Ali, Yefu Wang, Marek Michalak, Xing-Zhen Chen, Jingfeng Tang
Summary: Pancreatic cancer is characterized by poor prognosis and limited therapeutic options, driving the urgent need for new therapeutic targets. This study identified TSPAN1 as an upregulated gene in pancreatic cancer, correlated with poor patient survival, and demonstrated its role in regulating autophagy. Additionally, the study revealed that TSPAN1 is regulated by MIR454-FAM83A and plays a role in the proliferation of pancreatic cancer cells.
Article
Oncology
Shuhang Liang, Hongrui Guo, Kun Ma, Xianying Li, Dehai Wu, Yiqi Wang, Wei Wang, Shugeng Zhang, Yifeng Cui, Yufeng Liu, Linmao Sun, Bo Zhang, Mengyang Xin, Ning Zhang, Huanran Zhou, Yao Liu, Jiabei Wang, Lianxin Liu
Summary: PLCB1 acts as an oncogenic driver in cholangiocarcinoma development by activating the PI3K-AKT signaling pathway to induce EMT, and AKT inhibitors can be used as a therapeutic target to overcome chemotherapy resistance in CCA patients.
Article
Biochemistry & Molecular Biology
Elena Forzisi, Wei Yu, Parth Rajwade, Federico Sesti
Summary: IKCs, complexes formed by alpha 5-integrins and KCNB1 channels, transduce electrical activity into biochemical events. Under oxidative stress, IKCs activate apoptosis and suppress cell survival mechanisms. This study suggests that the combined action of integrins and KCNB1 channels determines cell fate.
Article
Endocrinology & Metabolism
Lai Wang, Lijun Zhu, Zuguo Zheng, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Yang
Summary: Statin use is associated with an increased risk of type 2 diabetes, but the underlying mechanisms and prevention strategies are not fully understood. This study identifies the mevalonate pathway and geranylgeranylation of RAB14 as regulators of hepatic insulin signaling and glucose metabolism. Supplementing with geranylgeranyl pyrophosphate (GGPP) may be an effective strategy to prevent the diabetic effects of statins.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Li Ma, Huan Liu, Xiaoxuan Wang, Chenxi Jiang, Siqi Yao, Yi Guo, Huiyi Wang, Zhengguo Cao
Summary: The study revealed that P. gingivalis has significant impact on cementoblasts, inducing inflammation, autophagy, and cell apoptosis. CXXC5 plays a regulatory role in this process, and P. gingivalis induces autophagy through Beclin1 and Atg5 activation, while also suppressing cell proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mengxin Li, Dong Song, Xuyang Chen, Xuanzhong Wang, Libo Xu, Mei Yang, Jiaying Yang, Dhan V. Kalvakolanu, Xiaodong Wei, Xiaorui Liu, Yang Li, Baofeng Guo, Ling Zhang
Summary: RSL3 inhibits glioma stem cell proliferation and induces their differentiation into astrocytes by suppressing the Tgm2/Akt/ID1 signaling axis instead of inducing ferroptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Oncology
Wen-Kai Shi, Qiao-Li Shang, Yong-Fu Zhao
Summary: This study investigates the role of SPC25 in promoting hepatocellular carcinoma (HCC) progression. It is found that SPC25 is highly expressed in HCC and associated with poor prognosis and metastasis. Silencing SPC25 inhibits invasion and migration of HCC cells in vitro and in vivo. The study also reveals that SPC25 affects genes associated with extracellular matrix-integrin interactions, and upregulation of ITGB4 partially reverses the decline in cell invasion and migration capacities caused by SPC25 silencing. Blocking both SPC25 and ITGB4 reduces phosphorylation of downstream elements in the integrin pathway. Overall, this research highlights the important role of SPC25 as both a prognostic indicator and a promoter of metastasis in HCC.
Article
Biochemistry & Molecular Biology
Alexandra R. Dvorscek, Craig McKenzie, Marcus J. Robinson, Zhoujie Ding, Catherine Pitt, Kristy O'Donnell, Dimitra Zotos, Robert Brink, David M. Tarlinton, Isaak Quast
Summary: IL-21 acts as a key regulator in the initial B cell response, accelerating cell cycle progression and fueling cyclic re-entry of B cells, thereby promoting plasma cell differentiation.
Article
Multidisciplinary Sciences
Barnabas P. Ilenwabor, Heidi Schigt, Andreas Kompatscher, Caro Bos, Malou Zuidscherwoude, Bram C. J. van der Eerden, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Summary: Autosomal dominant mutations in FAM111A cause Kenny-Caffey syndrome type 2, characterized by growth retardation and electrolyte imbalance. This study found that mice lacking the FAM111A gene maintained normal electrolyte balance on a standard diet.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Immunology
Isaak Quast, David Tarlinton
Summary: A new study reveals a novel protein immunization strategy that enhances the durability of germinal centers and improves immunological outcomes by delivering the protein slowly over a 12-day period.
Article
Multidisciplinary Sciences
Rens Peeters, Jorge Cuenca-Escalona, Esther A. Zaal, Anna T. Hoekstra, Anouk C. G. Balvert, Marcos Vidal-Manrique, Niek Blomberg, Sjoerd J. van Deventer, Rinke Stienstra, Julia Jellusova, Martin Giera, Luciana Hannibal, Ute Spiekerkoetter, Martin Ter Beest, Celia R. Berkers, Annemiek B. van Spriel
Summary: This study identifies CD37 as a crucial membrane protein that inhibits fatty acid metabolism in aggressive B-cell lymphoma. Deletion of CD37 leads to increased fatty acid oxidation and depletion of palmitate from serum. CD37 interacts with the fatty acid transporter FATP1 to inhibit the uptake of palmitate. Inhibition of CD37 results in the uptake and processing of exogenous palmitate into energy and essential building blocks for proliferation. Patients with CD37-negative lymphomas exhibit large lipid deposits and intracellular lipid droplets. Inhibition of carnitine palmitoyl transferase 1 A compromises viability and proliferation of CD37-deficient lymphomas.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Malou Zuidscherwoude, Mark K. K. van Goor, Sara R. R. Roig, Niky Thijssen, Merijn van Erp, Jack Fransen, Jenny van der Wijst, Joost G. G. Hoenderop
Summary: This study characterizes the interaction between functional TRPV5 and CaM, demonstrating that they interact in the absence of Ca2+ and the interaction is intensified with increasing Ca2+ concentrations. The CaM C-lobe achieves channel pore blocking, leading to channel inactivation. Furthermore, the study shows a Ca2+-dependent binding stoichiometry at the single channel level. This research proposes a new CaM-dependent regulation model for TRPV5, involving apoCaM interaction and lobe-specific actions, which is of significant physiological relevance given its role in Ca2+ transport in the kidney.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Endocrinology & Metabolism
Teodora V. V. Grigore, Malou Zuidscherwoude, Anna Witasp, Peter Barany, Annika Wernerson, Annette Bruchfeld, Hong Xu, Hannes Olauson, Joost Hoenderop
Summary: Disturbances in magnesium homeostasis are common in chronic kidney disease (CKD) patients and are associated with increased mortality. This study found that Fibroblast Growth Factor 23 (FGF23) is associated with renal magnesium handling in CKD patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Eva A. M. Hesius, Lidia van Laar, Margriet Oosterveld, Annemiek B. van Spriel, Blanca Scheijen, Jan Willem Leeuwis, Henri A. M. Marres, Patricia J. T. A. Groenen, Wendy B. C. Stevens, Ellen van Der Spek, Adriaan J. C. van den Brule, Brigiet M. Hoevenaars, Konnie M. Hebeda, Michiel van den Brand
Summary: LBCL-IRF4 is a newly identified subtype of large B cell lymphoma in the 2017 revised WHO classification, initially reported in children. This study aimed to assess the frequency of IRF4 rearrangements in adult DLBCLs that need to be reclassified as LBCL-IRF4 using FISH. Among 238 DLBCL patients, six (including the index patient) were found to have IRF4 rearrangements, and their immunohistochemical profile was consistent with LBCL-IRF4. This study highlights the importance of considering LBCL-IRF4 in older patients and at different anatomical sites.
Article
Immunology
Adam K. Wade-Vallance, Zhiyong Yang, Jeremy B. Libang, Marcus J. Robinson, David M. Tarlinton, Christopher D. C. Allen
Summary: Wade-Vallance et al. demonstrate that the binding of antigen or antibody to the B cell receptor triggers apoptosis in IgE plasma cells. This mechanism is relevant to allergic disease and its treatment through endogenous IgE regulation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jeroen H. A. Creemers, Ankur Ankan, Kit C. B. Roes, Gijs Schroeder, Niven Mehra, Carl G. Figdor, I. Jolanda M. de Vries, Johannes Textor
Summary: Late-stage cancer immunotherapy trials often result in unique survival curve shapes, and it is crucial to anticipate and adjust the trial design accordingly. This study used simulated trials based on three mathematical models to investigate the survival curve shapes associated with immunotherapies. By simulating different scenarios, the authors demonstrated how trial design choices can be scrutinized and potential pitfalls can be identified. They also provided web-based implementations of their simulation models to facilitate their use by biomedical researchers, doctors, and trialists.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ze Gong, Koen van den Dries, Rodrigo A. Migueles-Ramirez, Paul W. Wiseman, Alessandra Cambi, Vivek B. Shenoy
Summary: Podosomes are used by immune cells to generate forces, migrate, and search for foreign antigens. Individual podosomes probe their environment through oscillations, while multiple podosomes in a cluster coordinate in a wave-like fashion. However, the mechanisms governing these oscillations and wave dynamics are still unclear.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Joanne C. Clark, Eleyna M. Martin, Luis A. Moran, Ying Di, Xueqing Wang, Malou Zuidscherwoude, Helena C. Brown, Deirdre M. Kavanagh, Johan Hummert, Johannes A. Eble, Bernhard Nieswandt, David Stegner, Alice Y. Pollitt, Dirk-Peter Herten, Michael G. Tomlinson, Angel Garcia, Steve P. Watson
Summary: Fluorescence correlation spectroscopy was used to investigate the clustering of CLEC-2 induced by crosslinked nanobody ligands. The results showed that the valency of the ligands and the expression levels of CLEC-2 were important factors in determining the activation of CLEC-2. Divalent ligands were found to be partial agonists while tetravalent ligands stimulated platelet aggregation.
COMMUNICATIONS BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Ahmed M. Al-Kaisey, William Figgett, Joshua Hawson, Fabienne Mackay, Stephen A. Joseph, Jonathan M. Kalman
Summary: In the past decade, there has been growing interest in understanding the role of gut microbiota in the development of atrial fibrillation (AF). Studies have linked gut dysbiosis to traditional risk factors for AF such as hypertension and obesity, but whether gut dysbiosis directly affects arrhythmogenesis in AF remains unclear. This article provides an overview of the current understanding of the impact of gut dysbiosis and associated metabolites on AF, as well as discusses current therapeutic strategies and future directions.
ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW
(2023)
Editorial Material
Immunology
Zhoujie Ding, David Tarlinton
Summary: BALT, formed in the lung during infancy and declining over childhood, plays a role in localized immune reactions against airway infections, including the production of germinal center-like B cells specific for respiratory pathogens.
Review
Immunology
Laia Querol Cano, Vera-Marie E. Dunlock, Fabian Schwerdtfeger, Annemiek B. van Spriel
Summary: Immune receptors are organized in specialized domains on lymphocytes' plasma membrane, and membrane-organizing proteins such as tetraspanins and galectins play a crucial role in controlling the spatial organization of immune receptors and other signaling proteins. Deficiencies in specific tetraspanins and galectins can lead to impaired immune synapse formation, lymphocyte proliferation, antibody production, and migration, resulting in impaired immunity, tumor development, and autoimmunity. Unlike conventional ligand-receptor interactions, membrane organizers interact within the same cell and modulate receptor clustering, dynamics, and intracellular signaling.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Marjolein Schluck, Loek J. Eggermont, Jorieke Weiden, Carlijn Popelier, Lea Weiss, Bas Pilzecker, Sigrid Kolder, Anne Heinemans, Carla Rodriguez Mogeda, Martijn Verdoes, Carl G. Figdor, Roel Hammink
Summary: In this study, nanosized aAPCs immunofilaments were used to investigate the role of co-stimulatory molecules in T-cell signaling. The findings highlight the importance of CD28 and CD2 signaling in T-cell function and could be used for future design of cancer immunotherapies.
ADVANCED THERAPEUTICS
(2022)